Genome-wide association study of antipsychotic-induced QTc interval prolongation [0.03%]
抗精神病药引起的QTc间期延长的全基因组关联研究
K Aberg,D E Adkins,Y Liu et al.
K Aberg et al.
QT prolongation is associated with increased risk of cardiac arrhythmias. Identifying the genetic variants that mediate antipsychotic-induced prolongation may help to minimize this risk, which might prevent the removal of efficacious drugs ...
Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron [0.03%]
OCT1多态性对5-HT3受体拮抗剂洛胺酮和昂丹司琼的细胞摄取、血浆浓度及疗效的影响
M V Tzvetkov,A R Saadatmand,K Bokelmann et al.
M V Tzvetkov et al.
After uptake into liver cells, the antiemetic drugs tropisetron and ondansetron undergo metabolic inactivation by cytochrome P450 2D6 (CYP2D6). We investigated whether the hepatic organic cation transporter 1 (OCT1; SLC22A1) mediates cellul...
E M Peñas-Lledó,P Dorado,Z Agüera et al.
E M Peñas-Lledó et al.
CYP2D6 polymorphism is associated with variability in drug response, endogenous metabolism (that is, serotonin), personality, neurocognition and psychopathology. The relationship between CYP2D6 genetic polymorphism and the risk of eating di...
Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics [0.03%]
与代谢综合征患者所用非典型抗精神病药的INSIG1和INSIG2基因-基因互作关系
Y-J Liou,Y M Bai,E Lin et al.
Y-J Liou et al.
The use of atypical antipsychotics (AAPs) is associated with increasing the risk of the metabolic syndrome (MetS), which is an important risk factor for cardiovascular disease and diabetes. Two insulin-induced gene (INSIG) isoforms, designa...
Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project [0.03%]
GENDEP计划中抗抑郁药物治疗过程中自杀意念加重的全基因组关联研究
N Perroud,R Uher,M Y M Ng et al.
N Perroud et al.
Suicidal thoughts during antidepressant treatment have been the focus of several candidate gene association studies. The aim of the present genome-wide association study was to identify additional genetic variants involved in increasing sui...
Randomized Controlled Trial
The pharmacogenomics journal. 2012 Feb;12(1):68-77. DOI:10.1038/tpj.2010.70 2012
Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses [0.03%]
成人精神分裂症患者开抗精神病药物的细胞色素P450检测：系统评价和meta分析
N Fleeman,Y Dundar,R Dickson et al.
N Fleeman et al.
There is wide variability in the response of individuals to standard doses of antipsychotic drugs. It has been suggested that this may be partly explained by differences in the cytochrome P450 (CYP450) enzyme system responsible for metaboli...
S V Vormfelde,J Brockmöller
S V Vormfelde
Little is known about the genetic impact on loop diuretic effects. We newly investigated five genetic polymorphisms in 95 healthy volunteers, who had ingested bumetanide, frusemide and torsemide. The subjects excreted means of 20.2 g sodium...
Randomized Controlled Trial
The pharmacogenomics journal. 2012 Feb;12(1):45-53. DOI:10.1038/tpj.2010.68 2012
Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response [0.03%]
儿茶酚-O-甲基转移酶药理基因组学与选择性5-羟色胺再摄取抑制剂的反应关系
Y Ji,J Biernacka,K Snyder et al.
Y Ji et al.
We applied a systematic pharmacogenetic approach to investigate the role of genetic variation in the gene encoding catechol O-methyltransferase (COMT) in individual variation in selective serotonin reuptake inhibitor (SSRI) response among d...
Clinical Trial
The pharmacogenomics journal. 2012 Feb;12(1):78-85. DOI:10.1038/tpj.2010.69 2012
Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain [0.03%]
抗精神病药物致体重增加的多巴胺受体基因(_DRD1至_DRD5_)系统分析
D J Müller,C C Zai,M Sicard et al.
D J Müller et al.
Antipsychotic-induced weight gain has emerged as a serious complication in the treatment of patients with most antipsychotics. We have conducted the first in-depth examination of dopamine receptor genes in antipsychotic-induced weight gain....
Sequential changes in gene expression profiles in breast cancers during treatment with the aromatase inhibitor, letrozole [0.03%]
来曲唑治疗乳腺癌过程中基因表达模式的动态变化研究
W R Miller,A Larionov,T J Anderson et al.
W R Miller et al.
The study aim was to identify early (within 14 days) and late changes (by 3 months) in breast cancer gene expression profiles associated with neoadjuvant therapy with letrozole. RNA from sequential tumour biopsies in 54 patients was analyze...