Common allelic variants of the farnesyl diphosphate synthase gene influence the response of osteoporotic women to bisphosphonates [0.03%]
法尼基二磷酸合成酶基因的常见等位基因变异影响骨质疏松妇女对双膦酸盐的反应
J M Olmos,M T Zarrabeitia,J L Hernández et al.
J M Olmos et al.
Farnesyl diphosphate synthase (FDPS) is necessary for osteoclast survival and activity and is considered as a major molecular target of aminobisphosphonates. Our objective was to analyze the influence of FDPS polymorphisms on bone mineral d...
High-density lipoprotein (HDL) cholesterol: leveraging practice-based biobank cohorts to characterize clinical and genetic predictors of treatment outcome [0.03%]
高密度脂蛋白胆固醇(HDL胆固醇):利用基于实践的生物样本库队列来描述临床和遗传治疗结果预测因子
R A Wilke
R A Wilke
Over the past decade, large multicenter trials have unequivocally demonstrated that decreasing low-density lipoprotein (LDL) cholesterol can reduce both primary and secondary cardiovascular events in patients at risk. However, even in the c...
CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans [0.03%]
古巴人和尼加拉瓜人的细胞色素P450 2D6基因型和德布利索酮羟化表型
A Llerena,P Dorado,R Ramírez et al.
A Llerena et al.
CYP2D6 genotype and debrisoquine metabolic ratio (MR) were analyzed in 133 Nicaraguan Mestizos (NMs) and 260 Cubans divided into Cuban Mestizos (CMs) and White Cubans (WCs). The frequencies of poor metabolizers (MR12.6) were 6% in NMs, 3....
Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice [0.03%]
小鼠抗精神病药物引起的空嚼运动和锥体外系副作用的遗传性很高
J J Crowley,D E Adkins,A L Pratt et al.
J J Crowley et al.
Pharmacogenomics is yet to fulfill its promise of manifestly altering clinical medicine. As one example, a predictive test for tardive dyskinesia (TD) (an adverse drug reaction consequent to antipsychotic exposure) could greatly improve the...
Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics [0.03%]
一类药物基因组标志物的多变量模型检测及其在噻嘌呤药物药理遗传学中的应用
B L Fridley,G D Jenkins,A Batzler et al.
B L Fridley et al.
Often, analysis for pharmacogenomic studies involving multiple drugs from the same class is completed by analyzing each drug individually for association with genomic variation. However, by completing the analysis of each drug individually,...
Trastuzumab and beyond: sequencing cancer genomes and predicting molecular networks [0.03%]
曲妥珠单抗及其后的研究：癌症基因组的测序与分子网络的预测
D H Roukos
D H Roukos
Life diversity can now be clearly explored with the next-generation DNA sequencing technology, allowing the discovery of genetic variants among individuals, patients and tumors. However, beyond causal mutations catalog completion, systems m...
Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment [0.03%]
干扰素β-1a治疗对肌内注射多发性硬化症转录调控的网络分析
M Hecker,R H Goertsches,C Fatum et al.
M Hecker et al.
Interferon-β (IFN-β) is one of the major drugs for multiple sclerosis (MS) treatment. The purpose of this study was to characterize the transcriptional effects induced by intramuscular IFN-β-1a therapy in patients with relapsing-remittin...
Association of ABCB1 polymorphisms with survival and in vitro cytotoxicty in de novo acute myeloid leukemia with normal karyotype [0.03%]
ABCB1多态性与正常核型急性髓系白血病初治患者的生存及体外细胞毒作用的相关性研究
H Gréen,I J Falk,K Lotfi et al.
H Gréen et al.
Overexpression of the multi-drug transporter P-glycoprotein, encoded by the ABCB1 gene, is a clinically relevant problem in acute myeloid leukemia (AML). Polymorphisms in ABCB1 might contribute to cancer risk and therapeutic response. We th...
T M Baye,R A Wilke
T M Baye
There is great interest in characterizing the genetic architecture underlying drug response. For many drugs, gene-based dosing models explain a considerable amount of the overall variation in treatment outcome. As such, prescription drug la...
A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register [0.03%]
OLIG3/TNFAIP3基因标记与早期炎性多关节炎甲氨蝶呤治疗持续性相关：来自诺福郡骨关节炎登记处的结果
D Plant,T Farragher,E Flynn et al.
D Plant et al.
Whole-genome association studies in rheumatoid arthritis have identified single-nucleotide polymorphisms (SNPs) predisposing to disease with moderate risk. We aimed to investigate the role of these markers in predicting methotrexate (MTX) r...