SNP discovery, expression and cis-regulatory variation in the UGT2B genes [0.03%]
UGT2B基因的SNP识别、表达和顺式调控变异
C Sun,C Southard,D Huo et al.
C Sun et al.
UGT2B enzymes metabolize multiple endogenous and exogenous molecules, including steroid hormones and clinical drugs. However, little is known about the inter-individual variation in gene expression and its determinants. We re-sequenced cand...
S B Haga,J M O&#x;Daniel,G M Tindall et al.
S B Haga et al.
To assess public attitudes and interest in pharmacogenetic (PGx) testing, we conducted a random-digit-dial telephone survey of US adults, achieving a response rate of 42% (n=1139). Most respondents expressed interest in PGx testing to predi...
Association study of cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia [0.03%]
cannabinoid受体1(CNR1)基因与迟发性运动障碍的相关性研究
A K Tiwari,C C Zai,O Likhodi et al.
A K Tiwari et al.
Tardive dyskinesia (TD) is a severe, debilitating movement disorder observed in 25-30% of the patients treated with typical antipsychotics. Cannabinoid receptor 1 (CNR1) activators tend to inhibit movement, an effect prevented by rimonabant...
Multicenter Study
The pharmacogenomics journal. 2012 Jun;12(3):260-6. DOI:10.1038/tpj.2010.93 2012
Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin [0.03%]
SLCO1B1基因多态性(rs4149056)对辛伐他汀和阿托伐他汀所致肌病的影响差异研究
L R Brunham,P J Lansberg,L Zhang et al.
L R Brunham et al.
Statins reduce cardiovascular morbidity and mortality in appropriately selected patients. However, statin-associated myopathy is a significant risk associated with these agents. Recently, variation in the SLCO1B1 gene was reported to predic...
Comparative Study
The pharmacogenomics journal. 2012 Jun;12(3):233-7. DOI:10.1038/tpj.2010.92 2012
Genome-wide association study of serious blistering skin rash caused by drugs [0.03%]
药物所致重症大疱性皮疹的全基因组关联研究
Y Shen,P Nicoletti,A Floratos et al.
Y Shen et al.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe, potentially life threatening adverse drug reactions characterized by skin blistering. Previous studies have identified drug-specific and population-spe...
Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia [0.03%]
在治疗精神分裂症时对mGlu2/3激动剂LY2140023一水合物进行药物基因分析
W Liu,A C M Downing,L M Munsie et al.
W Liu et al.
The goal of this study was to identify genetic markers associated with LY2140023 monohydrate response in patients with schizophrenia. Variants in eight candidate genes related to the mechanism of action of LY2140023 or olanzapine were inves...
Clinical Trial
The pharmacogenomics journal. 2012 Jun;12(3):246-54. DOI:10.1038/tpj.2010.90 2012
Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy [0.03%]
三种基因胃癌化疗临床结果预测标志物
H K Kim,I J Choi,C G Kim et al.
H K Kim et al.
To identify transcriptional profiles predictive of the clinical benefit of cisplatin and fluorouracil (CF) chemotherapy to gastric cancer patients, endoscopic biopsy samples from 96 CF-treated metastatic gastric cancer patients were prospec...
Intuitive pharmacogenetics: spontaneous risperidone dosage is related to CYP2D6, CYP3A5 and ABCB1 genotypes [0.03%]
直觉药物基因组学：利培酮的自发剂量与CYP2D6、CYP3A5和ABCB1基因型有关
S Mas,P Gassò,S Alvarez et al.
S Mas et al.
The aim of this study is to evaluate whether the quantitative prescription of risperidone (dosage) is related to the patient's metabolic status. Metabolic status was defined in terms of the most relevant polymorphisms of CYP2D6 (*3, *4, *5,...
Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians [0.03%]
全球药理基因组学：人口多样性对巴西人种细胞色素P450 2C族多态性分布的影响
G Suarez-Kurtz,J P Genro,M O de Moraes et al.
G Suarez-Kurtz et al.
The impact of biogeographical ancestry, self-reported 'race/color' and geographical origin on the frequency distribution of 10 CYP2C functional polymorphisms (CYP2C8*2, *3, *4, CYP2C9*2, *3, *5, *11, CYP2C19*2, *3 and *17) and their haploty...