Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine [0.03%]
奥氮平治疗的精神分裂症患者GLP-1受体基因与糖负荷后胰岛素水平的关系研究
S Ono,Y Suzuki,N Fukui et al.
S Ono et al.
Several studies have shown increased rates of hyperglycemia and diabetes in schizophrenic patients treated with olanzapine. However, the underlying mechanism is poorly understood. Glucose-dependent insulinotropic polypeptide (GIP) is known ...
Gene expression in blood is associated with risperidone response in children with autism spectrum disorders [0.03%]
与自闭症光谱障碍儿童的利斯培酮反应相关的血液表达型
L Lit,F R Sharp,K Bertoglio et al.
L Lit et al.
Children with autism spectrum disorders (ASDs) often have severe behavioral problems. Not all children with these problems respond to atypical antipsychotic medications; therefore, we investigated whether peripheral blood gene expression be...
Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region [0.03%]
小檗碱和吴茱萸碱通过五羟色胺转运蛋白多态区域影响五羟色胺转运蛋白的表达
Y Hu,E A Ehli,J J Hudziak et al.
Y Hu et al.
The aim of this study was to investigate the effect of berberine and evodiamine on serotonin transporter (5-HTT) expression and then test how allelic variations previously identified in the promoter region could modulate that effect in the ...
An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics [0.03%]
ABCB1药物基因组学的最新研究进展：从三维模型看与药物动力学相关的SNPs所对应的作用位点及其进化保守性
S J Wolf,M Bachtiar,J Wang et al.
S J Wolf et al.
The human ABCB1 protein, (P-glycoprotein or MDR1) is a membrane-bound glycoprotein that harnesses the energy of ATP hydrolysis to drive the unidirectional transport of substrates from the cytoplasm to the extracellular space. As a large ran...
Cytidine deaminase single-nucleotide polymorphism is predictive of toxicity from gemcitabine in patients with pancreatic cancer: RTOG 9704 [0.03%]
胞嘧啶脱氨酶单核苷酸多态性预测胰腺癌吉西他滨毒性：RTOG 9704研究
J J Farrell,K Bae,J Wong et al.
J J Farrell et al.
The aim of this study is to validate the prognostic and predictive value of the non-synonymous cytidine deaminase (CDA) Lys²⁷Gln polymorphism for hematological toxicity and survival using a randomized phase III adjuvant trial (Radiation T...
Clinical Trial
The pharmacogenomics journal. 2012 Oct;12(5):395-403. DOI:10.1038/tpj.2011.22 2012
Genetics informatics trial (GIFT) of warfarin to prevent deep vein thrombosis (DVT): rationale and study design [0.03%]
基因信息试验(GIFT)：华法林预防深静脉血栓形成(DVT)的合理性与实验设计
E J Do,P Lenzini,C S Eby et al.
E J Do et al.
The risk of venous thromboembolism (VTE) is higher after the total hip or knee replacement surgery than after almost any other surgical procedure; warfarin sodium is commonly prescribed to reduce this peri-operative risk. Warfarin has a nar...
Randomized Controlled Trial
The pharmacogenomics journal. 2012 Oct;12(5):417-24. DOI:10.1038/tpj.2011.18 2012
Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes [0.03%]
用于戒烟的伐尼克兰：恶心程度及尼古丁受体基因多态性的差异的影响
G E Swan,H S Javitz,L M Jack et al.
G E Swan et al.
This study evaluated association between common and rare sequence variants in 10 nicotinic acetylcholine receptor subunit genes and the severity of nausea 21 days after initiating the standard, Food and Drug Administration-approved varenicl...
Randomized Controlled Trial
The pharmacogenomics journal. 2012 Aug;12(4):349-58. DOI:10.1038/tpj.2011.19 2012
Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations [0.03%]
对编码Lp-PLA2的PLA2G7基因的2000个欧洲人测序发现几个罕见的功能丧失型突变
K Song,M R Nelson,J Aponte et al.
K Song et al.
Elevated plasma levels of lipoprotein-associated phospholipase A(2) (Lp-PLA2) activity have been shown to be associated with increased risk of coronary heart disease and an inhibitor of this enzyme is under development for the treatment of ...
Polymorphism in multidrug resistance-associated protein gene 3 is associated with outcomes in childhood acute lymphoblastic leukemia [0.03%]
多药耐药相关蛋白基因3多态性与儿童急性淋巴细胞白血病预后有关
M Ansari,G Sauty,M Labuda et al.
M Ansari et al.
Multidrug resistance-related proteins (MRPs) 2, 3 and 5 are involved in the efflux of drugs used in acute lymphoblastic leukemia (ALL) treatment. Polymorphisms of these genes were investigated for an association with treatment responses in ...
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients [0.03%]
与多发性硬化症患者干扰素-β治疗产生抗体相关的HLA和非HLA基因单核苷酸多态性分析
F Weber,S Cepok,C Wolf et al.
F Weber et al.
Interferons-β (IFN-β) are the most widely used immunomodulatory drugs for treatment of multiple sclerosis (MS). The development of neutralizing antibodies (NABs) against IFN-β is one of the main reasons for treatment failure. While formu...
Multicenter Study
The pharmacogenomics journal. 2012 Jun;12(3):238-45. DOI:10.1038/tpj.2011.14 2012