Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy [0.03%]
nucleotide excision repair基因多态性与新辅助化疗骨肉瘤患者生存关系的研究
P Biason,C M Hattinger,F Innocenti et al.
P Biason et al.
The aim of this study was to investigate the role of common polymorphisms in the nucleotide excision repair pathway genes in the tumorigenesis of osteosarcoma and in the response to DNA damaging therapies, such as cisplatin-based neoadjuvan...
Background gene expression networks significantly enhance drug response prediction by transcriptional profiling [0.03%]
背景基因表达网络通过转录谱分析显著增强药物反应预测能力
A Torkamani,N J Schork
A Torkamani
A central goal of gene expression studies coupled with drug response screens is to identify predictive profiles that can be exploited to stratify patients. Numerous methods have been proposed towards this end, most of them focusing on novel...
Meta-Analysis
The pharmacogenomics journal. 2012 Oct;12(5):446-52. DOI:10.1038/tpj.2011.35 2012
DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia [0.03%]
神经药源性迟发性运动障碍候选基因DPP6的关联研究
S Tanaka,A Syu,H Ishiguro et al.
S Tanaka et al.
We implemented a two-step approach to detect potential predictor gene variants for neuroleptic-induced tardive dyskinesia (TD) in schizophrenic subjects. First, we screened associations by using a genome-wide (Illumina HumanHapCNV370) SNP a...
Support for association of HSPG2 with tardive dyskinesia in Caucasian populations [0.03%]
软骨寡聚基质蛋白与高加索人群迟发性运动障碍相关性的支持证据
L Greenbaum,A Alkelai,P Zozulinsky et al.
L Greenbaum et al.
Tardive dyskinesia (TD) is a severe adverse effect of chronic antipsychotic drug treatment. In addition to clinical risk factors, TD susceptibility is influenced by genetic predisposition. Recently, Syu et al. (2010) reported a genome-wide ...
Gender-stratified gene and gene-treatment interactions in smoking cessation [0.03%]
分性别进行的吸烟戒断基因及基因-治疗交互作用分析
W Lee,A W Bergen,G E Swan et al.
W Lee et al.
We conducted gender-stratified analyses on a systems-based candidate gene study of 53 regions involved in nicotinic response and the brain-reward pathway in two randomized clinical trials of smoking cessation treatments (placebo, bupropion,...
Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms [0.03%]
克罗恩病和溃疡性结肠炎的糖皮质激素抵抗与GR和FKBP5基因多态性的相关研究
P Maltese,L Palma,C Sfara et al.
P Maltese et al.
The aim of this study is to investigate the role of single-nucleotide polymorphisms (SNPs) of the glucocorticoid receptor (GR) and of the related co-chaperone FKBP5 genes in the development of glucocorticoid (GC) resistance in Crohn's disea...
TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials [0.03%]
CONFIRM-1和CONFIRM-2临床试验中转移性结直肠癌患者中TS及ERCC-1的表达与临床结果的关系
P P Grimminger,M Shi,C Barrett et al.
P P Grimminger et al.
To validate established cutoff levels of thymidylate synthase (TS) and excision repair cross-complementing (ERCC-1) intratumoral mRNA expressions in tumor samples from metastatic colorectal cancer (mCRC) patients treated with PTK787/ZK22258...
Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy [0.03%]
基质金属蛋白酶-9基因多态性影响妊娠期高血压疾病患者血浆MMP-9水平及降压治疗敏感性
A C T Palei,V C Sandrim,L M Amaral et al.
A C T Palei et al.
Abnormal matrix metalloproteinase (MMP)-9 levels may have a role in hypertensive disorders of pregnancy. We examined whether MMP-9 genetic polymorphisms (g.-1562C >T and g.-90(CA)13-25) modify plasma MMP-9 and tissue inhibitor of metallopro...
Methotrexate consolidation treatment according to pharmacogenetics of MTHFR ameliorates event-free survival in childhood acute lymphoblastic leukaemia [0.03%]
基于管芽醇脱氢酶基因的药剂遗传学调整甲氨蝶呤巩固治疗可改善儿童急性淋巴细胞白血病无事件生存率
J Salazar,A Altés,E del Río et al.
J Salazar et al.
Recent advances in treatment for childhood acute lymphoblastic leukaemia (ALL) have significantly increased outcome. High-dose methotrexate (MTX) is the most commonly used regimen during the consolidation period, but the optimal dose remain...
Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry [0.03%]
欧洲癌症患者的基因聚类表明阿片样物质介导的镇痛与种族无关
A Galvan,T Fladvad,F Skorpen et al.
A Galvan et al.
The European Pharmacogenetic Opioid Study (EPOS) of a large series of European cancer patients treated with opioids was carried out to assess the influence of genetics on cancer pain relief. As response to opioid therapy was associated with...