Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder [0.03%]
五羟色胺受体2A（HTR2A）基因多态性预测盐酸文拉法辛缓释片治疗惊恐障碍的有效性
F W Lohoff,T D Aquino,S Narasimhan et al.
F W Lohoff et al.
Generalized anxiety disorder (GAD) is a chronic psychiatric disorder with significant morbidity and mortality. Antidepressant drugs are the preferred choice for treatment; however, treatment response is often variable. Several studies in ma...
Clinical Trial
The pharmacogenomics journal. 2013 Feb;13(1):21-6. DOI:10.1038/tpj.2011.47 2013
ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease [0.03%]
ITPKC和CASP3基因多态性与川崎病静脉注射免疫球蛋白抵抗及冠状动脉病变风险的关系研究
Y Onouchi,Y Suzuki,H Suzuki et al.
Y Onouchi et al.
Functional single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) (rs28493229) and caspase-3 (CASP3) (rs113420705; formerly rs72689236) are associated with susceptibility to Kawasaki's disease (KD). To eva...
S M Tse,K Tantisira,S T Weiss
S M Tse
Despite the availability of several classes of asthma medications and their overall effectiveness, a significant portion of patients fail to respond to these therapeutic agents. Evidence suggests that genetic factors may partly mediate the ...
Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo [0.03%]
W16X麦拉ノ秦-4受体异常的体内和体外表征研究
F Bolze,N Rink,H Brumm et al.
F Bolze et al.
Several genetic diseases are triggered by nonsense mutations leading to the formation of truncated and defective proteins. Aminoglycosides have the capability to mediate a bypass of stop mutations during translation thus resulting in a resc...
MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms [0.03%]
MTHFR基因多态性与类风湿关节炎甲氨蝶呤疗效关系的病例分析及C677T和A1298C多态性的meta分析
S A Owen,M Lunt,J Bowes et al.
S A Owen et al.
Association of two key variants mapping to the MTHFR gene (C677T (rs1801133) and A1298C (rs1801131)) with response to methotrexate (MTX) remains controversial. We investigated these and other markers spanning the gene as predictors of MTX e...
Meta-Analysis
The pharmacogenomics journal. 2013 Apr;13(2):137-47. DOI:10.1038/tpj.2011.42 2013
A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients [0.03%]
日本患者利尿酸诱发的史蒂文斯-约翰逊综合征及中毒性表皮坏死溶解症全基因组关联研究
M Tohkin,N Kaniwa,Y Saito et al.
M Tohkin et al.
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe, cutaneous adverse drug reactions that are rare but life threatening. Genetic biomarkers for allopurinol-related SJS/TEN in Japanese were examined in a genome-wide...
CYP4A11 variant is associated with high-density lipoprotein cholesterol in women [0.03%]
CYP4A11变异体与女性高密度脂蛋白胆固醇相关性研究
C C White,Q Feng,L A Cupples et al.
C C White et al.
The ω-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to ω-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-α (PPARα) agonists. PPARα activation increases high-density lipopr...
High plasma efavirenz level and CYP2B6*6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naïve HIV patients from Ethiopia: a prospective cohort study [0.03%]
埃法韦仑基于的HAART治疗初治的埃塞俄比亚HIV患者引起的肝损伤与高水平的埃法韦仑及CYP2B6*6等位基因相关：前瞻性队列研究
G Yimer,W Amogne,A Habtewold et al.
G Yimer et al.
The objective of this study was to assess the incidence, timing and identify pharmacogenetic, efavirenz (EFV) pharmacokinetic and biochemical predictors of EFV-based antiretroviral therapy (ART) drug-induced liver injury (DILI). ART-naïve ...
Vascular endothelial growth factor polymorphisms and clinical outcome in colorectal cancer patients treated with irinotecan-based chemotherapy and bevacizumab [0.03%]
血管内皮生长因子多态性与伊立替康联合贝伐单抗治疗结直肠癌患者的临床结果相关性研究
A K Koutras,A G Antonacopoulou,A G Eleftheraki et al.
A K Koutras et al.
The aim of the study was to evaluate the association of vascular endothelial growth factor (VEGF) genotypes with treatment efficacy in a randomized trial. This study compared two chemotherapy regimens (FOLFIRI versus XELIRI) combined with b...
Randomized Controlled Trial
The pharmacogenomics journal. 2012 Dec;12(6):468-75. DOI:10.1038/tpj.2011.37 2012
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations [0.03%]
全基因组元分析鉴定出跨人群的铂类药物敏感性相关变异位点
H E Wheeler,E R Gamazon,A L Stark et al.
H E Wheeler et al.
Platinating agents are used in the treatment of many cancers, yet they can induce toxicities and resistance that limit their utility. Using previously published and additional world population panels of diverse ancestry totaling 608 lymphob...
Meta-Analysis
The pharmacogenomics journal. 2013 Feb;13(1):35-43. DOI:10.1038/tpj.2011.38 2013