Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy [0.03%]
ABCC2基因的遗传多态性与辛伐他汀和阿托伐他汀治疗过程中的剂量调整及换药风险的相关性研究
M L Becker,L L F S Elens,L E Visser et al.
M L Becker et al.
Several statins are substrates for the multidrug resistance-associated protein 2 transporter, encoded by the ABCC2 gene. We analyzed in the Rotterdam Study whether the common polymorphisms -24C>T, 1249G>A and 3972C>T in the ABCC2 gene were ...
M A Lowery,E M O&#x;Reilly
M A Lowery
The last decade has brought significant advances in the development of molecularly targeted therapies for treatment of a variety of human malignancies. In contrast to other solid tumors, however, the impact of novel therapeutic strategies o...
Pharmacogenetic predictors for EGFR-inhibitor-associated skin toxicity [0.03%]
表皮生长因子受体抑制剂相关性皮肤毒性的药物基因组预测指标
S Parmar,C Schumann,S Rüdiger et al.
S Parmar et al.
The aim of this study was to investigate pharmacogenetic determinants of skin rash associated with epidermal growth factor receptor (EGFR) inhibitor treatment. A total of 109 prospectively sampled cancer patients, receiving the first treatm...
How informative is a negative finding in a small pharmacogenetic study? [0.03%]
阴性结果的药理基因组学小型研究究竟能说明什么？
S-A Bacanu,J C Whittaker,M R Nelson
S-A Bacanu
Many pharmacogenetic studies fail to yield any statistically significant associations. Such negative findings may be due to the absence of, or inadequate statistical power to test for, an effect at the genetic variants tested. In many insta...
DNA-damage response gene polymorphisms and therapeutic outcomes in ovarian cancer [0.03%]
卵巢癌的基因多态性与治疗效果相关的研究进展——从DNA损伤反应的角度分析
E Caiola,L Porcu,R Fruscio et al.
E Caiola et al.
Epithelial ovarian cancer has a poor prognosis owing to late diagnosis and frequent relapse after first-line therapy. Analysis of individual genetic variability could aid in the identification of markers, which could help in stratifying pat...
A pharmacogenetic study of ADRB2 polymorphisms and indacaterol response in COPD patients [0.03%]
COPD患者中ADRB2多态性与茚达特罗反应的药理基因组学研究
R Yelensky,Y Li,S Lewitzky et al.
R Yelensky et al.
Genetic variation in the ADRB2 gene has been hypothesized to have a role in differential response to beta-agonist (BA) therapy in asthma. However, study results have been inconsistent and the issue remains controversial. Furthermore, the im...
Clinical Trial
The pharmacogenomics journal. 2012 Dec;12(6):484-8. DOI:10.1038/tpj.2011.54 2012
Inter-ethnic differences in lymphocyte sensitivity to glucocorticoids reflect variation in transcriptional response [0.03%]
族裔差异的淋巴细胞对糖皮质激素敏感性反映了转录反应的差异
J C Maranville,S S Baxter,J M Torres et al.
J C Maranville et al.
Glucocorticoids (GCs) are steroid hormones widely used as pharmaceutical interventions, which act mainly by regulating gene expression levels. A large fraction of patients (∼30%), especially those of African descent, show a weak response t...
A genomic approach to predict synergistic combinations for breast cancer treatment [0.03%]
基因组学预测乳腺癌治疗协同组合的方法
R Soldi,A L Cohen,L Cheng et al.
R Soldi et al.
We leverage genomic and biochemical data to identify synergistic drug regimens for breast cancer. In order to study the mechanism of the histone deacetylase (HDAC) inhibitors valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) in...
Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction [0.03%]
内皮型一氧化氮合酶基因型和单倍体型通过西地那非对勃起功能障碍患者的治疗反应产生影响
J J Muniz,R Lacchini,T O Rinaldi et al.
J J Muniz et al.
Erectile dysfunction (ED) is usually treated with sildenafil. Although genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may impair endogenous NO formation, there is little information about how eNOS polymorphisms a...
Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver [0.03%]
人类肝脏吸收、分布、代谢和排泄药物的相关基因表达的遗传图谱学研究
A Schröder,K Klein,S Winter et al.
A Schröder et al.
Expression quantitative trait loci (eQTL) analysis is a powerful approach toward identifying genetic loci associated with quantitative changes in gene expression. We applied genome-wide association analysis to a data set of >300 000 single-...