Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration [0.03%]
结直肠癌的药物基因组学：预测氟尿嘧啶或FOLFOX治疗后的毒性的全基因组关联研究
C Fernandez-Rozadilla,J B Cazier,V Moreno et al.
C Fernandez-Rozadilla et al.
The development of genotyping technologies has allowed for wider screening for inherited causes of variable outcomes following drug administration. We have performed a genome-wide association study (GWAS) on 221 colorectal cancer (CRC) pati...
Multicenter Study
The pharmacogenomics journal. 2013 Jun;13(3):209-17. DOI:10.1038/tpj.2012.2 2013
Array-based pharmacogenomics of molecular-targeted therapies in oncology [0.03%]
基于阵列的肿瘤分子靶向治疗药物基因组学研究
D Sanoudou,G Mountzios,D A Arvanitis et al.
D Sanoudou et al.
The advent of microarrays over the past decade has transformed the way genome-wide studies are designed and conducted, leading to an unprecedented speed of acquisition and amount of new knowledge. Microarray data have led to the identificat...
Heterochromatin as an incubator for pathology and treatment non-response: implication for neuropsychiatric illness [0.03%]
异染色质作为病理和治疗无反应的温床：对神经精神疾病的意义
R P Sharma,D P Gavin,K A Chase
R P Sharma
Heterochromatin is a higher order assembly that is characterized by a genome-wide distribution, gene-repression, durability and potential to spread. In this light, it is an appealing mechanism to interpret the neurobiology of complex brain ...
Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder [0.03%]
度洛西汀治疗广泛性焦虑障碍疗效的药物基因组学研究
R H Perlis,B Fijal,S Dharia et al.
R H Perlis et al.
We examined genetic associations with duloxetine response in generalized anxiety disorder (GAD). Three pooled studies in patients with GAD receiving duloxetine 60-120 mg per day (N=164) or placebo (N=95) were used. Associations between 825 ...
Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer [0.03%]
鸟苷酸合成酶新的mRNA剪接变异体及耐氟尿嘧啶的结直肠癌突变谱变异
M Griffith,J C Mwenifumbo,P Y Cheung et al.
M Griffith et al.
The drug fluorouracil (5-FU) is a widely used antimetabolite chemotherapy in the treatment of colorectal cancer. The gene uridine monophosphate synthetase (UMPS) is thought to be primarily responsible for conversion of 5-FU to active antica...
Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3 [0.03%]
有机阳离子转运蛋白3的遗传和表观遗传调控，SLC22A3
L Chen,C Hong,E C Chen et al.
L Chen et al.
Human organic cation transporter 3 (OCT3 and SLC22A3) mediates the uptake of many important endogenous amines and basic drugs in a variety of tissues. OCT3 is identified as one of the important risk loci for prostate cancer, and is markedly...
J Cohen,A Wilson,K Manzolillo
J Cohen
In this paper, we examine the clinical and economic challenges that face developers of and payers for personalized drugs and companion diagnostics. We review and summarize clinical, regulatory and reimbursement issues with respect to eight,...
Pharmacogenetic profiling of CD133 is associated with response rate (RR) and progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC), treated with bevacizumab-based chemotherapy [0.03%]
CD133的药物基因分型与贝伐单抗为基础的化疗治疗转移性结直肠癌患者的客观缓解率和无进展生存期有关
A Pohl,A El-Khoueiry,D Yang et al.
A Pohl et al.
Recent studies suggest CD133, a surface protein widely used for isolation of colon cancer stem cells, to be associated with tumor angiogenesis and recurrence. We hypothesized that gene expression levels and germline variations in CD133 will...
Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population [0.03%]
西班牙精神分裂症人群的利培酮不良反应的常见遗传变异相关性分析
B Almoguera,R Riveiro-Alvarez,J Lopez-Castroman et al.
B Almoguera et al.
Risperidone non-compliance is often high due to undesirable side effects, whose development is in part genetically determined. Studies with genetic variants involved in the pharmacokinetics and pharmacodynamics of risperidone have yielded i...
A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics [0.03%]
与哮喘患者支气管舒张反应相关的甲状腺激素受体基因多态性
Q L Duan,R Du,J Lasky-Su et al.
Q L Duan et al.
A pro-asthmatic culture milieu and β2-agonist (isoproterenol) were previously shown to regulate the expression of select transcription factors (TFs) within human airway epithelial and smooth muscle cells. This study tests 1116 single-nucle...