RYR3 gene polymorphisms and cardiovascular disease outcomes in the context of antihypertensive treatment [0.03%]
抗高血压治疗背景下RYR3基因多态性与心血管疾病转归的关系研究
A I Lynch,M R Irvin,E Boerwinkle et al.
A I Lynch et al.
Nearly one-third of adults in the United States have hypertension, which is associated with increased cardiovascular disease (CVD) morbidity and mortality. The goal of antihypertensive pharmacogenetic research is to enhance understanding of...
ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder [0.03%]
ABCB1基因变异通过影响选择性五羟色胺再摄取抑制剂的耐受性而对荷兰一大型主要抑郁障碍队列的疗效产生影响
O L de Klerk,I M Nolte,P M Bet et al.
O L de Klerk et al.
P-glycoprotein (P-gp), an ATP-driven efflux pump in the blood-brain barrier, has a major impact on the delivery of antidepressant drugs in the brain. Genetic variants in the gene ABCB1 encoding for P-gp have inconsistently been associated w...
Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms [0.03%]
遗传多态性影响下的卡马西平诱导过敏致小儿神经毒性分析报告
P Dorado,E López-Torres,E M Peñas-Lledó et al.
P Dorado et al.
Pharmacogenetic studies have shown that genetic defects in drug-metabolizing enzymes encoded by CYP2C9, CYP2C19 genes and by the transporter ABCB1 gene can influence phenytoin (PTH) plasma levels and toxicity. The patient reported here is a...
Predicting inhaled corticosteroid response in asthma with two associated SNPs [0.03%]
两种相关基因多态性位点预测哮喘吸入皮质激素的治疗反应
M J McGeachie,A C Wu,H-H Chang et al.
M J McGeachie et al.
Inhaled corticosteroids (ICS) are the most commonly used controller medications prescribed for asthma. Two single-nucleotide polymorphisms (SNPs), rs1876828 in corticotrophin releasing hormone receptor 1 and rs37973 in GLCCI1, have previous...
Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence [0.03%]
酒精依赖史后大鼠前额叶皮层中mRNA和microRNA的协调失调
J D Tapocik,M Solomon,M Flanigan et al.
J D Tapocik et al.
Long-term changes in brain gene expression have been identified in alcohol dependence, but underlying mechanisms remain unknown. Here, we examined the potential role of microRNAs (miRNAs) for persistent gene expression changes in the rat me...
Profiling of drug-metabolizing enzymes/transporters in CD33+ acute myeloid leukemia patients treated with Gemtuzumab-Ozogamicin and Fludarabine, Cytarabine and Idarubicin [0.03%]
CD33+急性髓系白血病患者使用Gemtuzumab-Ozogamicin和氟达拉滨、阿糖胞苷和idarubicin治疗的药物代谢酶/转运体特征分析
I Iacobucci,A Lonetti,A Candoni et al.
I Iacobucci et al.
Genetic heterogeneity in drug-metabolizing enzyme/transporter (DMET) genes affects specific drug-related cancer phenotypes. To investigate the relationships between genetic variation and response to treatment in acute myeloid leukemia (AML)...
Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder [0.03%]
CUX1基因多态性与抑郁症抗抑郁药疗效的关联研究
D Sasayama,A Hiraishi,M Tatsumi et al.
D Sasayama et al.
Association between response to antidepressant treatment and genetic polymorphisms was examined in two independent Japanese samples of patients with major depressive disorder (MDD). Genome-wide approach using the Illumina Human CNV370-quad ...
Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes [0.03%]
药物诱发的长QT综合征中新型罕见致病变异频繁出现在的先天性心律失常基因中
A H Ramirez,C M Shaffer,J T Delaney et al.
A H Ramirez et al.
Marked prolongation of the QT interval and polymorphic ventricular tachycardia following medication (drug-induced long QT syndrome, diLQTS) is a severe adverse drug reaction (ADR) that phenocopies congenital long QT syndrome (cLQTS) and is ...
The PPAR alpha gene is associated with triglyceride, low-density cholesterol and inflammation marker response to fenofibrate intervention: the GOLDN study [0.03%]
PPAR α基因与fenofibrate干预后患者的甘油三酯、低密度胆固醇及炎症指标的改变相关：来自“遗传与血脂干预研究”的数据
A C Frazier-Wood,J M Ordovas,R J Straka et al.
A C Frazier-Wood et al.
As a peroxisome proliferator-activated receptor alpha (PPARα) agonist, fenofibrate favorably modulates dyslipidemia and inflammation markers, which are associated with cardiovascular risk. To determine whether variation in the PPARα recep...
Clinical Trial
The pharmacogenomics journal. 2013 Aug;13(4):312-7. DOI:10.1038/tpj.2012.9 2013
Added value of pharmacogenetic testing in predicting statin response: results from the REGRESS trial [0.03%]
药学基因组检测在预测他汀疗效方面的应用价值：REGRESS试验结果分析
F H van der Baan,M J Knol,A H Maitland-van der Zee et al.
F H van der Baan et al.
It was investigated whether pharmacogenetic factors, both as single polymorphism and as gene-gene interactions, have an added value over non-genetic factors in predicting statin response. Five common polymorphisms were selected in apolipopr...
Clinical Trial
The pharmacogenomics journal. 2013 Aug;13(4):318-24. DOI:10.1038/tpj.2012.12 2013