Interaction of SLC1A1 gene variants and life stress on pharmacological resistance in obsessive-compulsive disorder [0.03%]
SLC1A1基因变异与生活压力对强迫症药物抵抗性的相互作用研究
E Real,M Gratacòs,J Labad et al.
E Real et al.
Genetic and environmental factors seem to interact and influence both the onset and the course of obsessive-compulsive disorder (OCD), but the role of glutamate transporter variants (SLC1A1) in pharmacological resistance is not known. We ai...
Pharmacogenetics and pharmacogenomics: role of mutational analysis in anti-cancer targeted therapy [0.03%]
药物基因组和药物基因体学：抗肿瘤靶向治疗中突变分析的作用
A Savonarola,R Palmirotta,F Guadagni et al.
A Savonarola et al.
The goal of cancer pharmacogenomics is to obtain benefit from personalized approaches of cancer treatment and prevention. Recent advances in genomic research have shed light on the crucial role of genetic variants, mainly involving genes en...
Use of pharmacogenetics in bioequivalence studies to reduce sample size: an example with mirtazapine and CYP2D6 [0.03%]
药物基因组学在生物等效性研究中减少样本量的应用——以米塔扎pine和CYP2D6为例
N González-Vacarezza,F Abad-Santos,A Carcas-Sansuan et al.
N González-Vacarezza et al.
In bioequivalence studies, intra-individual variability (CV(w)) is critical in determining sample size. In particular, highly variable drugs may require enrollment of a greater number of subjects. We hypothesize that a strategy to reduce ph...
Randomized Controlled Trial
The pharmacogenomics journal. 2013 Oct;13(5):452-5. DOI:10.1038/tpj.2012.29 2013
Can population differences in chemotherapy outcomes be inferred from differences in pharmacogenetic frequencies? [0.03%]
化疗结果的人口差异能否通过药物基因组频率的差异来推断？
M Loh,D Chua,Y Yao et al.
M Loh et al.
Inter-ethnic differences in drug handling and frequencies of pharmacogenetic variants are increasingly being characterized. In this study, we systematically assessed the feasibility of inferring ethnic trends in chemotherapy outcomes from i...
Meta-Analysis
The pharmacogenomics journal. 2013 Oct;13(5):423-9. DOI:10.1038/tpj.2012.26 2013
Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis [0.03%]
干扰素β-1b治疗多发性硬化短期和长期有效的分子标志物研究
E Croze,K D Yamaguchi,V Knappertz et al.
E Croze et al.
Interferon beta (IFNβ) reduces disease burden in relapsing-remitting multiple sclerosis (MS) patients. In this study, IFNβ-1b-treated MS patient gene expression profiles and biological knowledgebases were integrated to study IFNβ's pleio...
Comparative Study
The pharmacogenomics journal. 2013 Oct;13(5):443-51. DOI:10.1038/tpj.2012.27 2013
Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions [0.03%]
乙酰胆碱受体在他汀类药物诱导的神经肌肉不良反应中的作用的小鼠转基因模型研究
G E Grajales-Reyes,C A Báez-Pagán,H Zhu et al.
G E Grajales-Reyes et al.
High cholesterol levels are an established risk factor for cardiovascular disease (CVD), the world's leading cause of death. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (statins) are prescribed to lower serum cholesterol l...
Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit/hyperactivity disorder treated with methylphenidate [0.03%]
多动症儿童和青少年服用甲基苯丙胺治疗与羧酸酯酶1多态性减食之间的关联研究
E M Bruxel,A Salatino-Oliveira,J P Genro et al.
E M Bruxel et al.
Carboxylesterase 1 is the enzyme involved in methylphenidate (MPH) metabolism. The aim of this study was to evaluate the association between a -75 T>G polymorphism and appetite reduction in children with attention-deficit/hyperactivity diso...
Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression [0.03%]
ABCC2启动子多态性的功能表征及等位基因特异性表达
T D Nguyen,S Markova,W Liu et al.
T D Nguyen et al.
Multidrug resistance protein 2 (MRP2, ABCC2) is an efflux membrane transporter highly expressed in liver, kidney and intestine with important physiological and pharmacological roles. The goal of this study was to investigate the functional ...
A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer [0.03%]
晚期非小细胞肺癌患者伊立替康相关严重毒性的全基因组关联研究
J-Y Han,E S Shin,Y-S Lee et al.
J-Y Han et al.
The identification of patients who are at high risk for irinotecan-related severe diarrhea and neutropenia is clinically important. We conducted the first genome-wide association study (GWAS) to search for novel susceptibility genes for iri...
Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib) [0.03%]
化疗加血管内皮生长因子受体抑制剂PTK787/ZK 222584(vatalanib)治疗的结直肠癌患者瘤内抗血管生成基因表达谱分析
P M Wilson,D Yang,M Azuma et al.
P M Wilson et al.
The phase III CONFIRM clinical trials demonstrated that metastatic colorectal cancer patients with elevated serum lactate dehydrogenase (LDH) had improved outcome when the vascular endothelial growth factor receptor (VEGFR) inhibitor PTK/ZK...
Clinical Trial
The pharmacogenomics journal. 2013 Oct;13(5):410-6. DOI:10.1038/tpj.2012.23 2013