Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters [0.03%]
肥胖合并2型糖尿病患者代谢手术前后的人体肠道微生物组测序及其与炎症和代谢参数的相关性研究
J Graessler,Y Qin,H Zhong et al.
J Graessler et al.
Roux-en-Y gastric bypass (RYGB) has become a prominent therapeutic option for long-term treatment of morbid obesity and type 2 diabetes mellitus (T2D). Cross talk and pathogenetic consequences of RYGB-induced profound effects on metabolism ...
A genetic basis for the variable effect of smoking/nicotine on Parkinson's disease [0.03%]
吸烟/尼古丁对帕金森病影响的基因基础
E M Hill-Burns,N Singh,P Ganguly et al.
E M Hill-Burns et al.
Prior studies have established an inverse association between cigarette smoking and the risk of developing Parkinson's disease (PD), and currently, the disease-modifying potential of the nicotine patch is being tested in clinical trials. To...
VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction [0.03%]
血管内皮生长因子基因多态性影响阴茎海绵体血流及西地那非治疗阳痿的效应
R Lacchini,J J Muniz,Y T D A Nobre et al.
R Lacchini et al.
Vascular endothelial growth factor (VEGF) is a cytokine involved in angiogenesis and is closely related to the nitric oxide-cyclic guanosine monophosphate pathway, a target for sildenafil. We investigated for the first time whether three cl...
Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma [0.03%]
ORMDL3基因表达、17q21多态性和哮喘患儿吸入皮质类固醇反应的关系
V Berce,C E P Kozmus,U Potočnik
V Berce
Recent genome-wide association studies linked childhood asthma with single-nucleotide polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome 17q21. We analyzed the effect of functional SNP rs2872507 in ORMDL3 gene re...
Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans [0.03%]
小鼠单胺氧化酶(MAO)基因突变导致对增加血清素药物的过度敏感：人类副作用的含义
M A Fox,M G Panessiti,P R Moya et al.
M A Fox et al.
A possible side effect of serotonin-enhancing drugs is the serotonin syndrome, which can be lethal. Here we examined possible hypersensitivity to two such drugs, the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) and the atypical opioid...
Interaction between polymorphisms in serotonin transporter (SLC6A4) and serotonin receptor 2A (HTR2A) genes predict treatment response to venlafaxine XR in generalized anxiety disorder [0.03%]
五羟色胺转运蛋白（SLC6A4）和五羟色胺受体2A（HTR2A）基因多态性的交互作用可预测盐酸文拉法辛缓释片治疗 generalized anxiety disorder 的疗效
F W Lohoff,S Narasimhan,K Rickels
F W Lohoff
Variation in genes involved in serotonergic signaling is thought to be associated with antidepressant treatment response in generalized anxiety disorder (GAD). We examined a possible interaction between the serotonin transporter gene (SLC6A...
Clinical Trial
The pharmacogenomics journal. 2013 Oct;13(5):464-9. DOI:10.1038/tpj.2012.33 2013
Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment [0.03%]
KCNJ1基因多态性与氢氯噻嗪治疗过程中空腹血糖变化及新发糖尿病的关系
J H Karnes,C W McDonough,Y Gong et al.
J H Karnes et al.
Thiazide-induced potassium loss may contribute to new onset diabetes (NOD). KCNJ1 encodes a potassium channel and one study observed that a KCNJ1 single-nucleotide polymorphism (SNP) was associated with changes in fasting glucose (FG) durin...
Randomized Controlled Trial
The pharmacogenomics journal. 2013 Oct;13(5):430-6. DOI:10.1038/tpj.2012.34 2013
Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics [0.03%]
选择性五羟色胺再摄取抑制剂治疗重度抑郁障碍的药物基因组学：全基因组关联及功能基因组学
Y Ji,J M Biernacka,S Hebbring et al.
Y Ji et al.
A genome-wide association (GWA) study of treatment outcomes (response and remission) of selective serotonin reuptake inhibitors (SSRIs) was conducted using 529 subjects with major depressive disorder. While no SNP associations reached the g...
A prospective validation pharmacogenomic study in the adjuvant setting of colorectal cancer patients treated with the 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen [0.03%]
一项前瞻性药物基因组学研究：接受5-氟尿嘧啶/亚叶酸钙/奥沙利铂（FOLFOX4方案）辅助治疗的结直肠癌患者中的验证性研究
E Cecchin,M D&#x;Andrea,S Lonardi et al.
E Cecchin et al.
The discovery of pharmacogenomic markers in colorectal cancer (CRC) could be setting-specific. FOLFOX4 is employed in the adjuvant and metastatic setting in CRC. This prospective study is aimed to validate in the adjuvant setting the pharma...
Multicenter Study
The pharmacogenomics journal. 2013 Oct;13(5):403-9. DOI:10.1038/tpj.2012.31 2013
Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment [0.03%]
针对肌肉注射干扰素-β-1a多发性硬化症治疗的转录调控网络分析
M Hecker,R H Goertsches,C Fatum et al.
M Hecker et al.
Published Erratum
The pharmacogenomics journal. 2012 Aug;12(4):360. DOI:10.1038/tpj.2011.12 2012