Being precise with anticoagulation to reduce adverse drug reactions: are we there yet? [0.03%]
为了减少药物不良反应的精确抗凝治疗：我们达到目标了吗？
Benjamin Cross,Richard M Turner,J Eunice Zhang et al.
Benjamin Cross et al.
Anticoagulants are potent therapeutics widely used in medical and surgical settings, and the amount spent on anticoagulation is rising. Although warfarin remains a widely prescribed oral anticoagulant, prescriptions of direct oral anticoagu...
Pharmacogenetic and clinical risk factors for bevacizumab-related gastrointestinal hemorrhage in prostate cancer patients treated on CALGB 90401 (Alliance) [0.03%]
前列腺癌患者接受CALGB 90401（联盟）治疗时，与贝伐单抗相关的胃肠道出血的药理遗传学和临床风险因素
Jai N Patel,Chen Jiang,Kouros Owzar et al.
Jai N Patel et al.
The objective of this study was to discover clinical and pharmacogenetic factors associated with bevacizumab-related gastrointestinal hemorrhage in Cancer and Leukemia Group B (Alliance) 90401. Patients with metastatic castration-resistant ...
Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis [0.03%]
紫杉醇耐药TNBC中p300的上调：通过PCK1/AMPK途径影响细胞增殖的意义
Peng-Wei Zhao,Jia-Xian Cui,Xiu-Mei Wang
Peng-Wei Zhao
Objective: To explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-negative breast cancer (TNBC) cells, focusing on its interaction with the phosphoenolpyruvate carboxykinase 1 (PCK1)/adenosine...
Composite CYP3A (CYP3A4 and CYP3A5) phenotypes and influence on tacrolimus dose adjusted concentrations in adult heart transplant recipients [0.03%]
成人心脏移植受者他克莫司剂量调整浓度的复合型CYP3A（CYP3A4和CYP3A5）表型及其影响
Michelle Liu,Savine Hernandez,Christina L Aquilante et al.
Michelle Liu et al.
CYP3A5 genetic variants are associated with tacrolimus metabolism. Controversy remains on whether CYP3A4 increased [*1B (rs2740574), *1 G (rs2242480)] and decreased function [*22 (rs35599367)] genetic variants provide additional information...
The pharmacogenetics of tacrolimus in renal transplant patients: association with tremors, new-onset diabetes and other clinical events [0.03%]
肾移植患者他克莫司的药效基因组学：与震颤，新发糖尿病及其他临床事件的关系
Amani Abderahmene,Yassine Khalij,Amira Moussa et al.
Amani Abderahmene et al.
Our study is the first study to investigate the effect of SNPs in CYP3A5, CYP3A4, ABCB1 and POR genes on the incidence of tremors, nephrotoxicity, and diabetes mellitus. A total of 223 renal transplant patients receiving tacrolimus and myco...
Pharmacogenomic biomarker information on drug labels of the Spanish Agency of Medicines and Sanitary products: evaluation and comparison with other regulatory agencies [0.03%]
西班牙药品和卫生用品机构的药物标签上的药理基因组生物标志物信息：评估与其他监管机构进行比较
María Estévez-Paredes,M Carmen Mata-Martín,Fernando de Andrés et al.
María Estévez-Paredes et al.
This work aimed to analyse the pharmacogenetic information in the Spanish Drug Regulatory Agency (AEMPS) Summary of Products Characteristics (SmPC), evaluating the presence of pharmacogenetic biomarkers, as well as the associated recommenda...
Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity [0.03%]
将罕见基因变异整合到DPYD药物遗传学检测中可能有助于预防氟尿嘧啶诱导的毒性
Romain Larrue,Sandy Fellah,Benjamin Hennart et al.
Romain Larrue et al.
Variability in genes involved in drug pharmacokinetics or drug response can be responsible for suboptimal treatment efficacy or predispose to adverse drug reactions. In addition to common genetic variations, large-scale sequencing studies h...
Cytochrome P450-2D6 activity in people with codeine use disorder [0.03%]
.getCodeine成瘾者的细胞色素P450-2D6活性
Mark R C Daglish,Sarah R Reilly,Sam Mostafa et al.
Mark R C Daglish et al.
Compound-analgesics containing codeine (CACC) have been a common source of codeine for people seeking opioid replacement therapy (ORT) for codeine use disorder (CUD). Our previous work demonstrated no relationship between pre-treatment CACC...
A software tool to adjust codeine dose based on CYP2D6 gene-pair polymorphisms and drug-drug interactions [0.03%]
一种基于CYP2D6基因多态性和药物相互作用调整 кодеин剂量的软件工具
Yolande Saab,Zahi Nakad
Yolande Saab
Codeine is metabolized by the CYP2D6 enzyme, and individuals with certain genetic variations of the CYP2D6 gene may metabolize codeine differently, leading to variable efficacy and toxicity. Drug-drug interactions can also affect the metabo...
Pharmacogenetic and clinical predictors of voriconazole concentration in hematopoietic stem cell transplant recipients receiving CYP2C19-guided dosing [0.03%]
基于CYP2C19指导造血干细胞移植受者伏立康唑剂量的药物浓度药效学预测因素研究
Jai N Patel,Myra Robinson,Sarah A Morris et al.
Jai N Patel et al.
CYP2C19-guided voriconazole dosing reduces pharmacokinetic variability, but many patients remain subtherapeutic. The aim of this study was to evaluate the effect of candidate genes and a novel CYP2C haplotype on voriconazole trough concentr...