Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen [0.03%]
胰岛素样生长因子受体多态性决定雌激素受体阳性乳腺癌患者他莫昔芬治疗的临床预后
T Winder,G Giamas,P M Wilson et al.
T Winder et al.
Compelling evidence points to a key role for insulin-like growth factor 1 (IGF1) signaling in breast cancer development and progression. In addition, IGF1 receptor (IGF1R) expression has been correlated and functionally linked with estrogen...
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval [0.03%]
药物基因相互作用与寻找“缺失的遗传效应”：一项关于QT间期的横断面药物基因组学研究
C L Avery,C M Sitlani,D E Arking et al.
C L Avery et al.
Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the 'missing heritability' of complex traits. Here, we describe four independent analyses in 33 781 participa...
Meta-Analysis
The pharmacogenomics journal. 2014 Feb;14(1):6-13. DOI:10.1038/tpj.2013.4 2014
COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers [0.03%]
COMT Val158Met调节戒烟者的静脉注射尼古丁的主观反应和认知表现
A I Herman,P I Jatlow,J Gelernter et al.
A I Herman et al.
The catechol-O-methyltransferase (COMT) Val158Met polymorphism may be a risk factor for nicotine addiction. This study examined the influence of the COMT Val158Met polymorphism on subjective, physiological and cognitive effects of intraveno...
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans [0.03%]
全基因组关联分析提示NELL1影响非洲美国人的盐酸氢氯噻嗪不良代谢反应
J L Del-Aguila,A L Beitelshees,R M Cooper-Dehoff et al.
J L Del-Aguila et al.
Hydrochlorothiazide (HCTZ) is one of the most widely prescribed antihypertensive medications. Although it is well known that HCTZ is associated with hyperglycemia and hypertriglyceridemia, the mechanisms underlying these adverse effects are...
Meta-Analysis
The pharmacogenomics journal. 2014 Feb;14(1):35-40. DOI:10.1038/tpj.2013.3 2014
CYP2C9 polymorphism analysis in Han Chinese populations: building the largest allele frequency database [0.03%]
汉人人群CYP2C9多态性分析及建立最全等位基因频率数据库
D-P Dai,R-A Xu,L-M Hu et al.
D-P Dai et al.
Genetic polymorphisms of CYP2C9 significantly influence the pharmacokinetics and pharmacodynamics of some drugs, which might result in adverse drug effects and therapeutic failure. Several studies have been performed on CYP2C9 genetic polym...
Variation in the α 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content [0.03%]
α5亚型烟碱乙酰胆碱受体基因多态性预测尼古丁含量与吸烟强度的关系
D A Macqueen,B W Heckman,M D Blank et al.
D A Macqueen et al.
A single-nucleotide polymorphism (SNP) in the α5 nicotinic acetylcholine receptor subunit gene, rs16969968, has been repeatedly associated with both smoking and respiratory health phenotypes. However, there remains considerable debate as t...
Influence of admixture components on CYP2C9*2 allele frequency in eight indigenous populations from Northwest Mexico [0.03%]
墨西哥西北部八个人群中2C9*2等位基因频率的遗传混杂分析
M Sosa-Macías,B P Lazalde-Ramos,C Galaviz-Hernández et al.
M Sosa-Macías et al.
We previously documented the lowest frequency of CYP2C9*2 in Mexican indigenous Tepehuanos followed by Mestizos and Mexican-Americans populations, suggesting a negative correlation between the CYP2C9*2 frequency and the degree of Asian ance...
Gene polymorphisms that can predict response to anti-TNF therapy in patients with psoriasis and related autoimmune diseases [0.03%]
可用于预测银屑病及其相关自身免疫性疾病患者抗TNF治疗反应的基因多态性
R Prieto-Pérez,T Cabaleiro,E Daudén et al.
R Prieto-Pérez et al.
Psoriasis (Ps) is a chronic inflammatory disease with an important genetic component. It shares pathophysiological mechanisms with other autoimmune diseases such as psoriatic arthritis (PsA), rheumatoid arthritis (RA) and Crohn's disease (C...
Role of immunoglobulin G fragment C receptor polymorphism-mediated antibody-dependant cellular cytotoxicity in colorectal cancer treated with cetuximab therapy [0.03%]
免疫球蛋白G片段C受体多态性介导的抗体依赖性细胞毒性在西妥昔单抗治疗结直肠癌中的作用
F V Negri,A Musolino,N Naldi et al.
F V Negri et al.
Antibody-dependent cellular cytotoxicity (ADCC), which is activated by effector cells via immunoglobulin G (IgG) fragment C receptors (FcRs), was proposed as a mechanism of cetuximab efficacy. Peripheral blood mononuclear cells (PBMCs) from...
Clinical Trial
The pharmacogenomics journal. 2014 Feb;14(1):14-9. DOI:10.1038/tpj.2012.54 2014