Meta-analysis of the association between dopamine transporter genotype and response to methylphenidate treatment in ADHD [0.03%]
关于多巴胺转运蛋白基因型与注意缺陷多动障碍患儿对哌甲酯治疗反应的meta分析
J Kambeitz,M Romanos,U Ettinger
J Kambeitz
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent childhood-onset neuropsychiatric disorder. Treatment with methylphenidate, which blocks dopamine and noradrenaline transporters, is clinically efficacious in reducing the sympto...
Meta-Analysis
The pharmacogenomics journal. 2014 Feb;14(1):77-84. DOI:10.1038/tpj.2013.9 2014
Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent [0.03%]
非洲血统人群常用抗癌、抗艾滋病和治疗结核病药物发生不良反应风险的遗传变异频率较高
F Aminkeng,C J D Ross,S R Rassekh et al.
F Aminkeng et al.
There is established clinical evidence for differences in drug response, cure rates and survival outcomes between different ethnic populations, but the causes are poorly understood. Differences in frequencies of functional genetic variants ...
The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy [0.03%]
Cyclin D1（CCND1）rs9344 G>A多态性可预测结直肠癌患者辅助5-氟尿嘧啶类化疗临床结局
G Absenger,L Benhaim,J Szkandera et al.
G Absenger et al.
Recent evidence indicates a potential prognostic and predictive value for germline polymorphisms in genes involved in cell cycle control. We investigated the effect of cyclin D1 (CCND1) rs9344 G>A in stage II/III colon cancer patients and v...
Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome [0.03%]
生长激素缺乏症或特纳综合征儿童生长激素治疗过程中胰岛素样生长因子-I产生的药理基因组学
A Stevens,P Clayton,L Tatò et al.
A Stevens et al.
Individual responses to growth hormone (GH) treatment are variable. Short-term generation of insulin-like growth factor-I (IGF-I) is recognized as a potential marker of sensitivity to GH treatment. This prospective, phase IV study used an i...
Clinical Trial
The pharmacogenomics journal. 2014 Feb;14(1):54-62. DOI:10.1038/tpj.2013.14 2014
Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the treatment of early aggressive rheumatoid arthritis trial [0.03%]
早期类风湿关节炎甲氨蝶呤疗效及毒性相关基因变异：治疗早期侵袭性类风湿关节炎试验结果
S Aslibekyan,E E Brown,R J Reynolds et al.
S Aslibekyan et al.
Methotrexate (MTX) has emerged as first-line therapy for early moderate-to-severe rheumatoid arthritis (RA), but individual variation in treatment response remains unexplained. We tested the associations between 863 known pharmacogenetic va...
Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder [0.03%]
CYP2D6和CYP2C19基因多态性对强迫症抗抑郁治疗反应的影响
E J Brandl,A K Tiwari,X Zhou et al.
E J Brandl et al.
Numerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responde...
Synapsin II gene expression in the dorsolateral prefrontal cortex of brain specimens from patients with schizophrenia and bipolar disorder: effect of lifetime intake of antipsychotic drugs [0.03%]
精神分裂症和双相情感障碍标本中背外侧额叶皮层的synapsin Ⅱ基因表达：终生使用抗精神病药物的影响
M L Tan,B A Dyck,J Gabriele et al.
M L Tan et al.
Synapsins are neuronal phosphoproteins crucial to regulating the processes required for normal neurotransmitter release. Synapsin II, in particular, has been implied as a candidate gene for schizophrenia. This study investigated synapsin II...
Association of UGT1A1*28 polymorphisms with irinotecan-induced toxicities in colorectal cancer: a meta-analysis in Caucasians [0.03%]
UGT1A1*28多态性与结直肠癌伊立替康诱导的毒性：一项针对高加索人的荟萃分析研究
X Liu,D Cheng,Q Kuang et al.
X Liu et al.
A meta-analysis in Caucasians was conducted to investigate the possible association of uridine diphosphate glucuronosyltransferase (UGT) 1A1 gene polymorphisms with irinotecan (IRI)-induced neutropenia and diarrhoea in colorectal cancer (CR...
Meta-Analysis
The pharmacogenomics journal. 2014 Apr;14(2):120-9. DOI:10.1038/tpj.2013.10 2014
A genome-wide association study of bronchodilator response in asthmatics [0.03%]
哮喘患者气道扩张反应的全基因组关联研究
Q L Duan,J Lasky-Su,B E Himes et al.
Q L Duan et al.
Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) to inhaled albu...
A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy [0.03%]
用于治疗小细胞肺癌患者的伊立替康联合顺铂化疗的基因组广泛性关联研究以评估患者生存率
J-Y Han,Y-S Lee,E Soon Shin et al.
J-Y Han et al.
We conducted a genome-wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) influencing overall survival (OS) of small-cell lung cancer (SCLC) patients. We prospectively collected blood samples from 139 SCLC patie...