Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders [0.03%]
多巴胺和血清素基因变异通过注意缺陷多动障碍儿童哌甲酯的作用效果的影响
J T McCracken,K K Badashova,D J Posey et al.
J T McCracken et al.
Methylphenidate (MPH) reduces hyperactive-impulsive symptoms common in children with autism spectrum disorders (ASDs), however, response and tolerability varies widely. We hypothesized monoaminergic gene variants may moderate MPH effects in...
Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort [0.03%]
补体受体1基因变异与英国类风湿关节炎队列开始抗TNF治疗的患者基线红细胞沉降率水平相关：生物制剂在类风湿关节炎中的遗传和遗传学研究小组的结果
J Bluett,I Ibrahim,D Plant et al.
J Bluett et al.
Eligibility for anti-tumour necrosis factor (TNF) therapy in most European countries is restricted to severe, active rheumatoid arthritis (RA). The DAS28 score is a marker of disease severity and incorporates one of two inflammatory markers...
Pharmacogenomics, ancestry and clinical decision making for global populations [0.03%]
药物基因组学、谱系与面向全球人群的临床决策方法
E Ramos,A Doumatey,A G Elkahloun et al.
E Ramos et al.
Pharmacogenomically relevant markers of drug response and adverse drug reactions are known to vary in frequency across populations. We examined minor allele frequencies (MAFs), genetic diversity (FST) and population structure of 1156 geneti...
Association of common gene variants in the WNT/β-catenin pathway with colon cancer recurrence [0.03%]
结肠癌复发与WNT/β-链蛋白途径常见基因变异的相关性研究
D Páez,A Gerger,W Zhang et al.
D Páez et al.
Wnt/β-catenin signaling has a central role in the development and progression of most colon cancers (CCs). Germline variants in Wnt/β-catenin pathway genes may result in altered gene function and/or activity, thereby causing inter-individ...
Gender-specific profiling in SCN1A polymorphisms and time-to-recurrence in patients with stage II/III colorectal cancer treated with adjuvant 5-fluoruracil chemotherapy [0.03%]
基于性别分型的SCN1A多态性与II/III期结直肠癌术后5-氟尿嘧啶化疗患者复发时间的关系研究
L Benhaim,A Gerger,P Bohanes et al.
L Benhaim et al.
This study was designed to analyze the gender-related association between SCN1A polymorphisms (voltage-gated sodium channels; α-subunit) and time-to-recurrence (TTR) in patients with colorectal cancer (CRC) treated with 5-fluoruracil (5-FU...
Y Niinuma,T Saito,M Takahashi et al.
Y Niinuma et al.
Genetic variations in cytochrome P450 2C9 (CYP2C9) contribute to interindividual variability in the metabolism of clinically used drugs such as warfarin and tolbutamide. We functionally characterized 32 types of allelic variant CYP2C9 prote...
X Zheng,J Shen,C Cox et al.
X Zheng et al.
Genotyping of classical human leukocyte antigen (HLA) alleles is an essential tool in the analysis of diseases and adverse drug reactions with associations mapping to the major histocompatibility complex (MHC). However, deriving high-resolu...
Gene-expression differences in peripheral blood between lithium responders and non-responders in the Lithium Treatment-Moderate dose Use Study (LiTMUS) [0.03%]
锂治疗中剂量使用研究（LiTMUS）中锂响应者和非响应者外周血表达谱的差异分析
R D Beech,J J Leffert,A Lin et al.
R D Beech et al.
This study was designed to identify genes whose expression in peripheral blood may serve as early markers for treatment response to lithium (Li) in patients with bipolar disorder. Although changes in peripheral blood gene-expression may not...
Clinical Trial
The pharmacogenomics journal. 2014 Apr;14(2):182-91. DOI:10.1038/tpj.2013.16 2014
The role of the MTHFR 677C>T polymorphism in methotrexate-induced liver toxicity: a meta-analysis in patients with cancer [0.03%]
甲基蝶呤诱导的肝毒性中MTHFR C/T-677多态性作用的荟萃分析（癌症患者）
M M Hagleitner,M J H Coenen,R Aplenc et al.
M M Hagleitner et al.
Methotrexate (MTX), one of the important pillars in the treatment of different forms of cancer, is associated with the development of hepatotoxicity. The 677C>T variant (rs1801133) in the methylenetetrahydrofolate reductase (MTHFR) gene mig...
Meta-Analysis
The pharmacogenomics journal. 2014 Apr;14(2):115-9. DOI:10.1038/tpj.2013.19 2014
Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent [0.03%]
奥美拉唑代谢受依非韦伦诱导的影响与细胞色素酶2C19基因型有关
V Michaud,Y Kreutz,T Skaar et al.
V Michaud et al.
Efavirenz increases CYP2C19- and CYP3A-mediated omeprazole metabolism. We hypothesized that CYP2C19 and CYP2B6 genetic polymorphisms influence the extent of induction of omeprazole metabolism by efavirenz. Healthy subjects (n=57) were admin...