J Wakefield,V Skrivankova,F-C Hsu et al.
J Wakefield et al.
In a common pharmacogenomic scenario, outcome measures are compared for treated and untreated subjects across genotype-defined subgroups. The key question is whether treatment benefit (or harm) is particularly strong in certain subgroups, a...
Pharmacogenomics of NAT2 and ABCG2 influence the toxicity and efficacy of sulphasalazine containing DMARD regimens in early rheumatoid arthritis [0.03%]
NAT2和ABCG2的药物基因组学影响DMARD治疗方案中磺胺.salazine的毒性及疗效：在早期类风湿关节炎患者中的研究
M D Wiese,N Alotaibi,C O&#x;Doherty et al.
M D Wiese et al.
Sulphasalazine (SSA) is a disease modifying anti-rheumatic drug (DMARD) that is commonly used to treat rheumatoid arthritis (RA). Plasma levels of SSA and its metabolite sulphapyridine are influenced by common polymorphisms in genes that en...
Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes [0.03%]
肥胖糖尿病患者胃旁路手术前后的脂质组学分析
J Graessler,T D Bornstein,D Goel et al.
J Graessler et al.
Bariatric surgery is a well-established approach to improve metabolic disease in morbidly obese patients with high cardiovascular risk. The post-operative normalization of lipid metabolism has a central role in the prevention of future card...
T S C Yip,C O&#x;Doherty,N C K Tan et al.
T S C Yip et al.
In the current study, we have used the haplotype-tagging single-nucleotide polymorphisms (SNPs) to determine associations between genetic variants in SCN1A and treatment response in 519 Caucasian patients with known response status for epil...
High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase [0.03%]
载体CYP2C9*35对华法林敏感是由于与P450氧化还原酶相互作用受损所致
M-Y Lee,P Borgiani,I Johansson et al.
M-Y Lee et al.
Cytochrome P450 2C9 (CYP2C9) metabolizes many clinically important drugs including warfarin and diclofenac. We have recently reported a new allelic variant, CYP2C9*35, found in a warfarin hypersensitive patient with Arg125Leu and Arg144Cys ...
HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis [0.03%]
人类白细胞抗原A*31:01与卡马西平引起的不同类型的重症皮肤不良反应：一项国际研究和荟萃分析
E Genin,D-P Chen,S-I Hung et al.
E Genin et al.
HLA-A*31:01 was reported to be associated with carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCAR), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epiderma...
Meta-Analysis
The pharmacogenomics journal. 2014 Jun;14(3):281-8. DOI:10.1038/tpj.2013.40 2014
Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity [0.03%]
数据挖掘发现了一种早期反应基因网络作为药物诱导的体内外毒性的共识标志
J D Zhang,N Berntenis,A Roth et al.
J D Zhang et al.
Gene signatures of drug-induced toxicity are of broad interest, but they are often identified from small-scale, single-time point experiments, and are therefore of limited applicability. To address this issue, we performed multivariate anal...
The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation [0.03%]
细胞色素P450基因多态性与硫杂环戊烷的生成及以_busulfan_为基础的预处理方案在儿童造血干细胞移植中的疗效之间的关联研究
C R S Uppugunduri,M A Rezgui,P H Diaz et al.
C R S Uppugunduri et al.
Cytochrome P450 enzymes (CYPs) and flavin-containing monooxygenases (FMOs) likely have a role in the oxidation of intermediate metabolites of busulfan (Bu). In vitro studies to investigate the involvement of these enzymes are cumbersome bec...
Association of common genetic variants of HOMER1 gene with levodopa adverse effects in Parkinson's disease patients [0.03%]
帕金森病患者多巴胺不良反应与HOMER1基因常见变异的相关性研究
A F Schumacher-Schuh,V Altmann,M Rieck et al.
A F Schumacher-Schuh et al.
Levodopa is the most effective symptomatic therapy for Parkinson's disease, but its chronic use could lead to chronic adverse outcomes, such as motor fluctuations, dyskinesia and visual hallucinations. HOMER1 is a protein with pivotal funct...
Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females [0.03%]
欧洲美国女性OPRD1基因多态性与丁丙诺啡治疗阿片类物质依赖的关系研究
T-K Clarke,R C Crist,A Ang et al.
T-K Clarke et al.
Two commonly prescribed treatments for opioid addiction are methadone and buprenorphine. Although these drugs show some efficacy in treating opioid dependence, treatment response varies among individuals. It is likely that genetic factors h...