J-Y Han,Y-S Lee,B C Kim et al.
J-Y Han et al.
We performed whole-genome sequencing (WGS) of a case of early-stage small-cell lung cancer (SCLC) to analyze the genomic features. WGS revealed a lot of single-nucleotide variations (SNVs), small insertion/deletions and chromosomal abnormal...
PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway [0.03%]
PPP3CC基因：通过B细胞受体信号转导途径可能调节抗抑郁药疗效的候选基因
C Fabbri,A Marsano,D Albani et al.
C Fabbri et al.
Antidepressant pharmacogenetics represents a stimulating, but often discouraging field. The present study proposes a combination of several methodologies across three independent samples. Genes belonging to monoamine, neuroplasticity, circa...
The effect of the UGT1A1*28 allele on survival after irinotecan-based chemotherapy: a collaborative meta-analysis [0.03%]
UGT1A1*28基因型对伊立替康为基础的化疗疗效的影响：协作meta分析
M M Dias,J-P Pignon,C S Karapetis et al.
M M Dias et al.
To date, studies of irinotecan pharmacogenetics have mostly focused on the effect of the UGT1A1*28 allele on irinotecan-related toxicity. However, the clinical utility of routine UGT1A1*28 genotyping to pre-emptively adjust irinotecan dosag...
Meta-Analysis
The pharmacogenomics journal. 2014 Oct;14(5):424-31. DOI:10.1038/tpj.2014.16 2014
Clinical impact of the HGF/MET pathway activation in patients with advanced gastric cancer treated with palliative chemotherapy [0.03%]
肝细胞生长因子/间质上皮转化受体信号通路活化在晚期胃癌患者姑息化疗中的临床意义
F Graziano,V Catalano,P Lorenzini et al.
F Graziano et al.
In gastric cancer, available clinical studies focusing on the activated hepatocyte growth factor (HGF)/MET pathway are limited to surgical and often heterogeneous series. MET copy number gain (CNG) and an activating truncation in the HGF pr...
Effect of CYP2D6, CYP2C9 and ABCB1 genotypes on fluoxetine plasma concentrations and clinical improvement in children and adolescent patients [0.03%]
CYP2D6、CYP2C9和ABCB1基因多态性对氟西汀血药浓度及儿童青少年患者临床疗效的影响
P Gassó,N Rodríguez,S Mas et al.
P Gassó et al.
There is little known about pharmacogenetic of fluoxetine in children and adolescents. In this study, we evaluate, for the first time, the influence of CYP2D6, CYP2C9 and ABCB1 genotypes on the steady-state plasma concentrations of fluoxeti...
Observational Study
The pharmacogenomics journal. 2014 Oct;14(5):457-62. DOI:10.1038/tpj.2014.12 2014
Association between methylenetetrahydrofolate reductase polymorphisms and the relapse of acute lymphoblastic leukemia: a meta-analysis [0.03%]
亚甲基四氢叶酸还原酶基因多态性与急性淋巴细胞白血病复发的关系：一项Meta分析
H-R He,S-Y Chen,H-S You et al.
H-R He et al.
Relapse is a threat in patients treated for acute lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) activity may affect the sensitivity of patients to folate-based chemotherapeutic drugs, thus influencing the relapse...
Meta-Analysis
The pharmacogenomics journal. 2014 Oct;14(5):432-8. DOI:10.1038/tpj.2014.10 2014
A multi-marker molecular signature approach for treatment-specific subgroup identification with survival outcomes [0.03%]
基于生存结局的治疗特异性亚组识别的多标记分子特征谱系方法
L Li,T Guennel,S Marshall et al.
L Li et al.
Delivering on the promise of personalized medicine has become a focus of the pharmaceutical industry as the era of the blockbuster drug is fading. Central to realizing this promise is the need for improved analytical strategies for effectiv...
A systematic review of antipsychotic drug effects on human gene expression related to risk factors for cardiovascular disease [0.03%]
抗精神病药物对人体心血管疾病危险因素相关基因表达的影响的系统评价
D L Foley,A Mackinnon
D L Foley
Psychosis is associated with an elevated risk for cardiovascular disease. We reviewed evidence for a causal association between experimentally controlled antipsychotic drug exposure and a change in the expression of genes relevant to cardio...
Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: an integrated analysis of metabolic and transcriptomic data [0.03%]
小胎龄儿追赶与非追赶生长的病理生理学研究：代谢及转录组数据整合分析
A Stevens,C Bonshek,A Whatmore et al.
A Stevens et al.
Small for gestational age (SGA) children exhibiting catch-up (CU) growth have a greater risk of cardiometabolic diseases in later life compared with non-catch-up (NCU) SGA children. The aim of this study was to establish differences in meta...
Comparative Study
The pharmacogenomics journal. 2014 Aug;14(4):376-84. DOI:10.1038/tpj.2014.4 2014
A N Burska,K Roget,M Blits et al.
A N Burska et al.
Gene expression has recently been at the forefront of advance in personalized medicine, notably in the field of cancer and transplantation, providing a rational for a similar approach in rheumatoid arthritis (RA). RA is a prototypic inflamm...