Identification of SNPs associated with response of breast cancer patients to neoadjuvant chemotherapy in the EORTC-10994 randomized phase III trial [0.03%]
通过EORTC-10994随机三期临床试验鉴定与乳腺癌患者对新辅助化疗反应相关的SNPs
V Le Morvan,S Litière,A Laroche-Clary et al.
V Le Morvan et al.
Using cell line panels we identified associations between single-nucleotide polymorphisms (SNPs) and chemosensitivity. To validate these findings in clinics, we genotyped a subset of patients included in a neoadjuvant breast cancer trial to...
Clinical Trial
The pharmacogenomics journal. 2015 Feb;15(1):63-8. DOI:10.1038/tpj.2014.24 2015
Tissue inhibitor of matrix metalloproteinase-1 polymorphism, plasma TIMP-1 levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy [0.03%]
基质金属蛋白酶抑制剂-1基因多态性、血浆TIMP-1水平与妊娠期高血压疾病的降压治疗反应性关系的研究
M R Luizon,A C T Palei,V C Sandrim et al.
M R Luizon et al.
Tissue inhibitor of metalloproteinase (TIMP)-1 is a major endogenous inhibitor of matrix metalloproteinase (MMP)-9, which may affect the responsiveness to therapy in hypertensive disorders of pregnancy. We examined whether TIMP-1 polymorphi...
A pharmacogenetic study of ABCB1 polymorphisms and cyclosporine treatment response in patients with psoriasis in the Greek population [0.03%]
希腊人群中ABCB1多态性和环孢素治疗银屑病反应的药物基因组学研究
Y Vasilopoulos,C Sarri,E Zafiriou et al.
Y Vasilopoulos et al.
Psoriasis affects 2-3% of the population, causing significant morbidity and financial burden. Immunosuppressive drugs such as cyclosporine are first line systemic therapies for moderate-to-severe forms. However, patients exhibit heterogenei...
L R Brunham,S L Chan,R Li et al.
L R Brunham et al.
Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼ 4500 genetic variants in key drug-biotransfo...
Distribution of genetic polymorphisms associated with hepatitis C virus (HCV) antiviral response in a multiethnic and admixed population [0.03%]
多民族和混合人群遗传多态分布与丙型肝炎病毒抗病毒反应相关性研究
J Trinks,M L Hulaniuk,M Caputo et al.
J Trinks et al.
The prevalence of genetic polymorphisms identified as predictors of therapeutic-induced hepatitis C virus (HCV) clearance differs among ethnic groups. However, there is a paucity of information about their prevalence in South American popul...
Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease [0.03%]
核因子κB信号通路的功能多态性与丹麦炎症性肠病患者抗肿瘤坏死因子治疗反应的相关性研究
S Bank,P S Andersen,J Burisch et al.
S Bank et al.
Antitumor necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment...
Association of PAX4 genetic variants with oral antidiabetic drugs efficacy in Chinese type 2 diabetes patients [0.03%]
PAX4基因多态性与中国2型糖尿病口服降糖药疗效的关联分析
M Chen,C Hu,R Zhang et al.
M Chen et al.
The aim of this study was to investigate the association of PAX4 variants with therapeutic effect of oral antidiabetic drugs in Chinese type 2 diabtes mellitus (T2DM) patients. A total of 209 newly diagnosed T2DM patients were randomly assi...
Randomized Controlled Trial
The pharmacogenomics journal. 2014 Oct;14(5):488-92. DOI:10.1038/tpj.2014.18 2014
Ancestry-based pharmacogenomics, adverse reactions and carbamazepine: is the FDA warning correct? [0.03%]
基于遗传的药物基因组学、不良反应及卡马西平：FDA的警告是否正确？
P W Payne
P W Payne
In an effort to prevent potentially fatal adverse reactions to carbamazepine, the US Food and Drug Administration (FDA) issued an alert in 2007 containing pharmacogenomic information, which is still in effect today. The alert states that ca...
Pharmacogenetics of pemetrexed combination therapy in lung cancer: pathway analysis reveals novel toxicity associations [0.03%]
肺鳞癌培美曲塞联合用药的药物基因组学：通路分析揭示了新的毒性关联
A Corrigan,J L Walker,S Wickramasinghe et al.
A Corrigan et al.
Identification of polymorphisms that influence pemetrexed tolerability could lead to individualised treatment regimens and improve quality of life. Twenty-eight polymorphisms within eleven candidate genes were genotyped using the Illumina H...
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases [0.03%]
全基因组数据在一大型幼年特发性关节炎队列中揭示了甲氨蝶呤反应的新基因
J Cobb,E Cule,H Moncrieffe et al.
J Cobb et al.
Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification coul...