APF2: an improved ensemble method for pharmacogenomic variant effect prediction [0.03%]
改进的药理遗传学变异效应预测集成方法APF2
Yitian Zhou,Sebastian Pirmann,Volker M Lauschke
Yitian Zhou
Lack of efficacy or adverse drug response are common phenomena in pharmacological therapy causing considerable morbidity and mortality. It is estimated that 20-30% of this variability in drug response stems from variations in genes encoding...
Pharmacogenomics in Lebanon: current status, challenges and opportunities [0.03%]
黎巴嫩的药物基因组学：现状、挑战与机遇
Lorenzo Chidiac,Hady Yazbeck,Rami Mahfouz et al.
Lorenzo Chidiac et al.
Pharmacogenomics (PGx) research and applications are of utmost relevance in Lebanon considering its population genetic diversity. Moreover, as a country with regional leadership in medicine and higher education, Lebanon holds a strong poten...
Inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T>C (rs11706052) and 12-month evolution of the graft function in renal transplant recipients on mycophenolate-based immunosuppression [0.03%]
鸟苷单磷酸脱氢酶第二型基因多型性(IMPDH2 3757T>C，rs11706052)与肾移植受者接受霉酚酸免疫抑制治疗一年后移入器官功能的演变关系
Luka Penezić,Sandra Nađ-Škegro,Ayla Hadžavdić et al.
Luka Penezić et al.
Variant allele at the inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T>C has been associated with increased enzyme activity and reduced susceptibility to mycophenolic acid (MPA) in vitro. It has been suggested associated...
Cost-effectiveness analysis of CYP3A5 genotype-guided tacrolimus dosing in solid organ transplantation using real-world data [0.03%]
基于真实世界数据的CYP3A5基因型指导Tacrolimus剂量个体化在器官移植中的成本效益分析
Kimberly M Deininger,Heather D Anderson,George P Patrinos et al.
Kimberly M Deininger et al.
The objective of this study was to estimate the cost-effectiveness of CYP3A5 genotype-guided tacrolimus dosing in kidney, liver, heart, and lung transplant recipients relative to standard of care (SOC) tacrolimus dosing, from a US healthcar...
Study on genotype and phenotype of novel CYP2D6 variants using pharmacokinetic and pharmacodynamic models with metoprolol as a substrate drug [0.03%]
基于美托洛尔的药动学和药效学模型研究新型CYP2D6变异体的基因型与表型关系
Jianchang Qian,Tao Xu,Peipei Pan et al.
Jianchang Qian et al.
To investigate the pharmacokinetic and pharmacodynamic profiles of volunteers carrying CYP2D6 genotypes with unknow metabolic phenotypes, a total of 22 volunteers were recruited based on the sequencing results. Peripheral blood and urine sa...
Polygenic scores for cardiovascular risk factors improve estimation of clinical outcomes in CCB treatment compared to pharmacogenetic variants alone [0.03%]
与仅使用药物基因组变异相比，心血管风险因素的多基因评分可改善钙通道阻滞剂治疗的临床结果估算
Deniz Türkmen,Jack Bowden,Jane A H Masoli et al.
Deniz Türkmen et al.
Pharmacogenetic variants are associated with clinical outcomes during Calcium Channel Blocker (CCB) treatment, yet whether the effects are modified by genetically predicted clinical risk factors is unknown. We analyzed 32,000 UK Biobank par...
Pharmacogenomic study-A pilot study of the effect of pharmacogenomic phenotypes on the adequate dosing of verapamil for migraine prevention [0.03%]
药理基因组学研究-药理基因表型对偏头痛预防用药维拉帕米合理剂量影响的试点研究
Yi-Chieh Chen,Han Wang,Jayawant N Mandrekar et al.
Yi-Chieh Chen et al.
Objective: To investigate factors affecting the efficacy and tolerability of verapamil for migraine prevention using individual pharmacogenomic phenotypes. ...
Cost-utility analysis of pharmacogenomics-guided tacrolimus treatment in Austrian kidney transplant recipients participating in the U-PGx PREPARE study [0.03%]
奥地利U-PGx PREPARE研究中肾移植受者的他克莫司治疗的药物基因组学引导的成本效益分析
Vasileios Fragoulakis,Margarita-Ioanna Koufaki,Candace Joefield-Roka et al.
Vasileios Fragoulakis et al.
Chronic kidney disease (CKD) is a global health issue. Kidney failure patients may undergo a kidney transplantation (KTX) and prescribed an immunosuppressant medication i.e., tacrolimus. Tacrolimus' efficacy and toxicity varies among patien...
A review of real-world evidence on preemptive pharmacogenomic testing for preventing adverse drug reactions: a reality for future health care [0.03%]
预防药物不良反应的前瞻性药物基因组学检测的真实世界证据综述：未来的医疗现实
Santenna Chenchula,Shubham Atal,Chakradhara Rao S Uppugunduri
Santenna Chenchula
Adverse drug reactions (ADRs) are a significant public health concern and a leading cause of hospitalization; they are estimated to be the fourth leading cause of death and increasing healthcare costs worldwide. Carrying a genetic variant c...
Network pharmacology prediction, molecular docking and in vitro experiment explored the potential mechanism of Gaoyuan'an capsule in improving hypoxia tolerance [0.03%]
网络药理学预测、分子对接及体外实验探讨高原安胶囊提高缺氧耐受力的潜在机制
Tianbo Jin,Xiaoli Liu,Yuhe Wang et al.
Tianbo Jin et al.
Background: Tibetan medicine Gaoyuan'an capsule (GYAC) is widely used to prevent pulmonary edema at high altitude, but the specific mechanism has not been explored. In this study, we analyzed the mechanism of GYAC in hypo...