Gene signatures of drug resistance predict patient survival in colorectal cancer [0.03%]
药物抗性基因特征可预测结直肠癌患者生存期
Y Zheng,J Zhou,Y Tong
Y Zheng
Different combinations of 5-fluorouracil (5-FU), oxaliplatin, irinotecan and other newly developed agents have been used to treat colorectal cancer. Despite the advent of new treatment regimens, the 5-year survival rate for metastatic color...
Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents [0.03%]
硫嘌呤甲基转移酶状态检验以安全有效地应用硫嘌呤药物的临床指导文件系统性回顾
H F Burnett,R Tanoshima,W Chandranipapongse et al.
H F Burnett et al.
A common pharmacogenomic test is for thiopurine S-methyltransferase (TPMT) status prior to treatment with thiopurine drugs, used to treat auto-immune conditions and pediatric cancer. Guidelines assist practitioners with decisions regarding ...
N-acetyltransferase 1 polymorphism increases cotinine levels in Caucasian children exposed to secondhand smoke: the CCAAPS birth cohort [0.03%]
第二手烟暴露的儿童中N-乙酰化酶1多态性增加可尼丁水平：来自CCAAPS出生队列的数据
G K LeMasters,G K Khurana Hershey,U Sivaprasad et al.
G K LeMasters et al.
Cotinine is a proxy for secondhand smoke (SHS) exposure. Genetic variation along nicotine and cotinine metabolic pathways may alter the internal cotinine dose, leading to misinterpretations of exposure-health outcome associations. Caucasian...
The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol [0.03%]
酒精作用的分子效应检测模型：突触神经素转录谱分析
D Most,L Ferguson,Y Blednov et al.
D Most et al.
Chronic alcohol consumption changes gene expression, likely causing persistent remodeling of synaptic structures via altered translation of mRNAs within synaptic compartments of the cell. We profiled the transcriptome from synaptoneurosomes...
Genetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trial [0.03%]
葡萄糖和胰岛素性状位点的遗传变异与葡萄糖-胰岛素-钾治疗反应：来自立即试验的结果
K L Ellis,Y Zhou,J R Beshansky et al.
K L Ellis et al.
The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in cardiac ischemia are not well understood. We conducted a genetic sub-study of the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatm...
Randomized Controlled Trial
The pharmacogenomics journal. 2015 Feb;15(1):55-62. DOI:10.1038/tpj.2014.41 2015
A combined high CYP2D6-CYP2C19 metabolic capacity is associated with the severity of suicide attempt as measured by objective circumstances [0.03%]
联合型高细胞色素P450 2D6-2C19代谢容量与自杀行为的严重程度有关（由客观环境决定）
E Peñas-Lledó,S Guillaume,M E G Naranjo et al.
E Peñas-Lledó et al.
This study examined, for the first time, whether a high CYP2D6-CYP2C19 metabolic capacity combination increases the likelihood of suicidal intent severity in a large study cohort. Survivors of a suicide attempt (n=587; 86.8% women) were gen...
Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer [0.03%]
他莫昔芬代谢预测早期乳腺癌绝经前患者药物浓度及疗效
P Saladores,T Mürdter,D Eccles et al.
P Saladores et al.
Tamoxifen is the standard-of-care treatment for estrogen receptor-positive premenopausal breast cancer. We examined tamoxifen metabolism via blood metabolite concentrations and germline variations of CYP3A5, CYP2C9, CYP2C19 and CYP2D6 in 58...
Observational Study
The pharmacogenomics journal. 2015 Feb;15(1):84-94. DOI:10.1038/tpj.2014.34 2015
Clinical and pharmacogenomic implications of genetic variation in a Southern Ethiopian population [0.03%]
遗传变异在埃塞俄比亚南部人口中的临床和药理基因组学意义
Fasil Tekola-Ayele,Adebowale Adeyemo,Abraham Aseffa et al.
Fasil Tekola-Ayele et al.
Africa is home to genetically diverse human populations. We compared the genetic structure of the Wolaita ethnic population from Southern Ethiopia (WETH, n=120) with HapMap populations using genome-wide variants. We investigated allele freq...
Randomized Controlled Trial
The pharmacogenomics journal. 2015 Feb;15(1):101-108. DOI:10.1038/tpj.2014.39 2015
Genes involved in pericyte-driven tumor maturation predict treatment benefit of first-line FOLFIRI plus bevacizumab in patients with metastatic colorectal cancer [0.03%]
与周细胞诱导的肿瘤成熟相关的基因可预测转移性结直肠癌一线FOLFIRI联合贝伐珠单抗治疗效益
N B Volz,S Stintzing,W Zhang et al.
N B Volz et al.
Pericytes are crucial for angiogenesis. The impact of pericyte function to bevacizumab efficacy in mCRC treatment has not been comprehensively examined. This retrospective study investigated germline polymorphisms in genes related to early ...
Clinical Trial
The pharmacogenomics journal. 2015 Feb;15(1):69-76. DOI:10.1038/tpj.2014.40 2015
Therapeutic implications of novel mutations of the RFX6 gene associated with early-onset diabetes [0.03%]
RFX6基因的新突变与早发糖尿病的治疗意义
R Artuso,A Provenzano,B Mazzinghi et al.
R Artuso et al.
Identification of the genetic defect underlying early-onset diabetes is important for determining the specific diabetes subtype, which would then permit appropriate treatment and accurate assessment of recurrence risk in offspring. Given th...