D Naidoo,A C Wu,M H Brilliant et al.
D Naidoo et al.
Several reports have shown that statin treatment benefits patients with asthma; however, inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress HLA-G expressi...
In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia [0.03%]
一种CYP3A4多态性通过与性别相互作用可能影响儿童急性淋巴细胞白血病化疗疗效及生存率
A Gézsi,O Lautner-Csorba,D J Erdélyi et al.
A Gézsi et al.
CYP3A4 has an important role in the metabolisms of many drugs used in acute lymphoblastic leukemia (ALL) therapy; still, there are practically no publications about the role of CYP3A4 polymorphisms in ALL pharmacogenomics. We genotyped eigh...
Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents [0.03%]
OPRM1 A118G变异与青少年脊柱融合术后吗啡致呼吸抑制风险的相关性分析
V Chidambaran,J Mavi,H Esslinger et al.
V Chidambaran et al.
The μ1 opioid receptor (OPRM1) genetic variant A118G results in decreased μ-receptor binding potential in the brain and increases morphine requirement. We hypothesized that OPRM1 A118G polymorphism will affect morphine-induced respiratory...
Observational Study
The pharmacogenomics journal. 2015 Jun;15(3):255-62. DOI:10.1038/tpj.2014.59 2015
Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders [0.03%]
NEGR1基因多态性对进食障碍患者心理特征的影响分析
C Gamero-Villarroel,L María González,I Gordillo et al.
C Gamero-Villarroel et al.
Genetics variants in the NEGR1 gene, strongly expressed in the brain, have been reported to affect the neuronal control of food intake therefore inducing obesity. With the same rationale, we hypothesized that this genetic variability may be...
Influence of CYP2D6 and CYP2C19 genotypes on venlafaxine metabolic ratios and stereoselective metabolism in forensic autopsy cases [0.03%]
CYP2D6和CYP2C19基因多态性对中国人的伐尼克兰对映异构体代谢的影响及其立体选择性代谢规律研究
L Karlsson,A-L Zackrisson,M Josefsson et al.
L Karlsson et al.
We investigated whether polymorphisms in the CYP2D6 and CYP2C19 genes influence the metabolic ratios and enantiomeric S/R ratios of venlafaxine (VEN) and its metabolites O-desmethylvenlafaxine (ODV), N-desmethylvenlafaxine (NDV) and N,O-did...
ABCB1 polymorphisms predict imatinib response in chronic myeloid leukemia patients: a systematic review and meta-analysis [0.03%]
ABCB1多态性可预测慢性粒细胞白血病患者伊马替尼的疗效：一项系统评价和 meta 分析
Q Zheng,H Wu,Q Yu et al.
Q Zheng et al.
Imatinib mesylate, a competitive tyrosine kinase inhibitor, is considered the first-line therapy drug for Ph+ chronic myeloid leukemia (CML). Three single-nucleotide polymorphisms (SNPs) in the ATP-binding cassette, subfamily B (MDR/TAP), m...
Meta-Analysis
The pharmacogenomics journal. 2015 Apr;15(2):127-34. DOI:10.1038/tpj.2014.54 2015
Genetic polymorphisms in the mevalonate pathway affect the therapeutic response to alendronate treatment in postmenopausal Chinese women with low bone mineral density [0.03%]
中国绝经后低骨密度妇女遗传多态性对阿仑膦酸钠疗效的影响研究
C Wang,H Zheng,J-W He et al.
C Wang et al.
Alendronate is an antiosteoporotic drug that targets the mevalonate pathway. To investigate whether the genetic variations in this pathway affect the clinical efficacy of alendronate in postmenopausal Chinese women with osteopenia or osteop...
Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies [0.03%]
CYP3A5*3基因对肾移植受者他克莫司治疗疗效的影响：观察性研究的系统评价和meta分析
L Rojas,I Neumann,M José Herrero et al.
L Rojas et al.
The highly variable pharmacokinetics of tacrolimus can hamper the optimal management of kidney transplant patients. This variability has been attributed to the genetic polymorphism of CYP3A5 6986A>G, but the evidence is not clear. We conduc...
Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide [0.03%]
跨种族元分析提示血红素生物合成途径的遗传多态性影响氯噻嗪治疗患者的钾离子反应
J L Del-Aguila,R M Cooper-DeHoff,A B Chapman et al.
J L Del-Aguila et al.
Hypokalemia is a recognized adverse effect of thiazide diuretic treatment. This phenomenon, which may impair insulin secretion, has been suggested to be a reason for the adverse effects on glucose metabolism associated with thiazide diureti...
Meta-Analysis
The pharmacogenomics journal. 2015 Apr;15(2):153-7. DOI:10.1038/tpj.2014.46 2015
Direct PCR: a new pharmacogenetic approach for the inexpensive testing of HLA-B*57:01 [0.03%]
直接PCR：一种用于HLA-B*57:01廉价表型检测的药物基因组学新方法
R Cascella,C Strafella,M Ragazzo et al.
R Cascella et al.
One of the most successful applications of pharmacogenetics research is the genetic screening for HLA-B*57:01, strongly associated with an increased risk to develop hypersensitivity reaction in HIV-positive patients following abacavir admin...