FKBP5 variation is associated with the acute and chronic effects of nicotine [0.03%]
FKBP5基因多态性与尼古丁的急性及慢性效应相关
K P Jensen,A I Herman,M E Morean et al.
K P Jensen et al.
Stress and hormones released in response to stress influence the effects of nicotine and the severity of nicotine withdrawal. Here, we systematically examine the contribution of a stress response gene, FKBP5, to the acute and chronic behavi...
Integrin genetic variants and stage-specific tumor recurrence in patients with stage II and III colon cancer [0.03%]
结肠癌二期和三期患者肿瘤特异性整合素基因变异与复发风险之间的关系研究
P Bohanes,D Yang,F Loupakis et al.
P Bohanes et al.
Integrins (ITGs) are key elements in cancer biology, regulating tumor growth, angiogenesis and lymphangiogenesis through interactions of the tumor cells with the microenvironment. Moving from the hypothesis that ITGs could have different ef...
ABCB1 (MDR1) predicts remission on P-gp substrates in chronic depression [0.03%]
ABCB1（MDR1）可预测慢性抑郁症对P-糖蛋白底物的缓解作用
A Ray,L Tennakoon,J Keller et al.
A Ray et al.
The hypothesis that allelic variation in the multidrug resistance-1 (MDR1 or ABCB1) gene encoding the P-glycoprotein (P-gp) blood-brain barrier efflux pump is associated with remission and side effects was tested in chronic major depression...
Association study of UGT1A9 promoter polymorphisms with DILI based on systematically regional variation screen in Chinese population [0.03%]
基于国人系统区域性筛选的UGT1A9启动子多态性与药物肝毒性的关联研究
J Jiang,X Zhang,R Huo et al.
J Jiang et al.
Drug-induced liver injury (DILI) is caused by unpredictable adverse drug reaction due mainly to the accumulation of hepatotoxic compounds in the liver resulting in significant damage. Drug-metabolizing enzymes have been prime targets for mo...
An in silico screen links gene expression signatures to drug response in glioblastoma stem cells [0.03%]
利用计算分析建立基因表达模式与胶质母细胞瘤干细胞药物反应之间的联系
G Riddick,H Song,S L Holbeck et al.
G Riddick et al.
Cancer stem cells (CSCs) are thought to promote resistance to chemotherapeutic drugs in glioblastoma, the most common and aggressive primary brain tumor. However, the use of high-throughput drug screens to discover novel small-molecule inhi...
Genetic variation in the α1A-adrenergic receptor and phenylephrine-mediated venoconstriction [0.03%]
α1A-肾上腺素受体的基因多态性与norphenylephrine介导的静脉收缩的关系研究
A Adefurin,L V Ghimire,U Kohli et al.
A Adefurin et al.
There is large interindividual variability and ethnic differences in phenylephrine-mediated vasoconstriction. We tested the hypothesis that genetic variation in ADRA1A, the α1A adrenergic receptor gene, contributes to the variability and e...
Association of the PDE3A-SLCO1C1 locus with the response to anti-TNF agents in psoriasis [0.03%]
PDE3A-SLCO1C1基因座与银屑病抗TNF药物反应的关联研究
A Julià,C Ferrándiz,E Dauden et al.
A Julià et al.
Psoriasis is a prevalent autoimmune disease of the skin that causes significant psychological and physical disability. Tumor necrosis factor (TNF)-blocking agents have proven to be highly efficacious in the management of moderate-to-severe ...
Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia [0.03%]
多药耐药蛋白4(MRP4)的基因多态性影响日本儿童急性淋巴细胞白血病维持治疗期间硫嘌呤剂量耐受性
Y Tanaka,A Manabe,H Fukushima et al.
Y Tanaka et al.
Multidrug resistance protein 4 (MRP4) is involved in the efflux of nucleoside derivatives and has a role in the determination of drug sensitivity. We investigated the relationship between MRP4 genetic polymorphisms and doses of the 6-mercap...
Quality control metrics improve repeatability and reproducibility of single-nucleotide variants derived from whole-genome sequencing [0.03%]
质量控制指标可提高全基因组测序衍生的单核苷酸变异的一致性和再现性
W Zhang,V Soika,J Meehan et al.
W Zhang et al.
Although many quality control (QC) methods have been developed to improve the quality of single-nucleotide variants (SNVs) in SNV-calling, QC methods for use subsequent to single-nucleotide polymorphism-calling have not been reported. We de...
A B P van Kuilenburg,M-C Etienne-Grimaldi,A Mahamat et al.
A B P van Kuilenburg et al.
Dihydropyrimidine dehydrogenase is a crucial enzyme for the degradation of 5-fluorouracil (5FU). DPYD, which encodes dihydropyrimidine dehydrogenase, is prone to acquire genomic rearrangements because of the presence of an intragenic fragil...
Multicenter Study
The pharmacogenomics journal. 2015 Jun;15(3):211-8. DOI:10.1038/tpj.2014.68 2015