Clinical validity: Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes [0.03%]
临床诊断效度：药物基因组学预测抗抑郁药的疗效和卫生资源利用率优于单一基因表型
C A Altar,J M Carhart,J D Allen et al.
C A Altar et al.
In four previous studies, a combinatorial multigene pharmacogenomic test (GeneSight) predicted those patients whose antidepressant treatment for major depressive disorder resulted in poorer efficacy and increased health-care resource utiliz...
LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-fluorouracil-based adjuvant chemotherapy [0.03%]
LGR5基因rs17109924多态性可预测结肠癌术后5-FU类辅助化疗的复发时间
J Szkandera,S Herzog,M Pichler et al.
J Szkandera et al.
We recently found variants in cancer stem cell genes (CD44, ALCAM and LGR5) significantly associated with increased time to recurrence (TTR) in patients with stage III and high-risk stage II colon cancer treated with 5-fluorouracil (5-FU)-b...
Network analysis of gene expression in peripheral blood identifies mTOR and NF-κB pathways involved in antipsychotic-induced extrapyramidal symptoms [0.03%]
基于周边血液的基因表达网络分析鉴别出与抗精神病药物致锥体外系不良反应相关的mTOR和NF-κB通路
S Mas,P Gassó,E Parellada et al.
S Mas et al.
To identify the candidate genes for pharmacogenetic studies of antipsychotic (AP)-induced extrapyramidal symptoms (EPS), we propose a systems biology analytical approach, based on protein-protein interaction network construction and functio...
Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma [0.03%]
药动型基因组关联研究鉴定出哮喘糖皮质激素治疗反应新相关位点
Y Wang,C Tong,Z Wang et al.
Y Wang et al.
Asthma is a chronic lung disease that has a high prevalence. The therapeutic intervention of this disease can be made more effective if genetic variability in patients' response to medications is implemented. However, a clear picture of the...
Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies [0.03%]
细胞色素P450 2J2是环磷酰胺活化的一个新的关键酶，并且可能是血液系统恶性肿瘤的一个潜在生物标志物
I El-Serafi,M Fares,M Abedi-Valugerdi et al.
I El-Serafi et al.
The role of cytochrome P450 2J2 (CYP2J2) in cyclophosphamide (Cy) bioactivation was investigated in patients, cells and microsomes. Gene expression analysis showed that CYP2J2 mRNA expression was significantly (P
Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia [0.03%]
ABCB1基因多态性与儿童急性淋巴细胞白血病预后及毒副反应的关系研究
J Gregers,H Gréen,I J Christensen et al.
J Gregers et al.
The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect outcome and toxicity in childhood acute lymphoblastic leukemia (ALL). We...
Human organic cation transporter 1 (hOCT1) as a mediator of bendamustine uptake and cytotoxicity in chronic lymphocytic leukemia (CLL) cells [0.03%]
人源有机阳离子转运体1（hOCT1）作为苯达莫司汀在慢性淋巴细胞白血病（CLL）细胞中摄取和毒性作用的介导者
C Arimany-Nardi,A Montraveta,E Lee-Vergés et al.
C Arimany-Nardi et al.
Bendamustine is used in the treatment of chronic lymphocytic leukemia (CLL). Routes for bendamustine entry into target cells are unknown. This study aimed at identifying transporter proteins implicated in bendamustine uptake. Our results sh...
Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects [0.03%]
FAAH基因变异与术后中枢性阿片类药物不良反应的新联系
S Sadhasivam,X Zhang,V Chidambaran et al.
S Sadhasivam et al.
Opioid effects are potentiated by cannabinoid agonists including anandamide, an endocannabinoid. Inter-individual variability in responses to opioids is a major clinical problem. Multiple deaths and anoxic brain injuries occur every year be...
Clinical Trial
The pharmacogenomics journal. 2015 Oct;15(5):436-42. DOI:10.1038/tpj.2014.79 2015
Influence of ABCB1 polymorphisms upon the effectiveness of standard treatment for acute myeloid leukemia: a systematic review and meta-analysis of observational studies [0.03%]
ABCB1多态性对急性髓系白血病常规治疗疗效影响的系统评价和荟萃分析
J E Megías-Vericat,L Rojas,M J Herrero et al.
J E Megías-Vericat et al.
The ABCB1 gene encodes for P-glycoprotein (P-gp), an efflux pump for a variety of xenobiotics. The role of ABCB1 polymorphisms in acute myeloid leukemia (AML) outcomes of standard chemotherapy (cytarabine plus anthracyclines) remains contro...
Meta-Analysis
The pharmacogenomics journal. 2015 Apr;15(2):109-18. DOI:10.1038/tpj.2014.80 2015
Distinct gene expression profiles of proximal and distal colorectal cancer: implications for cytotoxic and targeted therapy [0.03%]
近端和远端结直肠癌的基因表达特征不同：细胞毒性和靶向治疗的启示
M K H Maus,D L Hanna,C L Stephens et al.
M K H Maus et al.
Colorectal cancer (CRC) is a heterogeneous disease with genetic profiles and clinical outcomes dependent on the anatomic location of the primary tumor. How location has an impact on the molecular makeup of a tumor and how prognostic and pre...