A prospective randomized evaluation of a pharmacogenomic approach to antiplatelet therapy among patients with ST-elevation myocardial infarction: the RAPID STEMI study [0.03%]
随机研究基因组学导向的血小板聚集抑制治疗STEMI患者：RAPID-STEMI试验
D Y F So,G A Wells,R McPherson et al.
D Y F So et al.
Treatment of carriers of the CYP2C19*2 allele and ABCB1 TT genotype with clopidogrel is associated with increased ischemic complications after percutaneous coronary intervention (PCI). We sought to evaluate a pharmacogenomic strategy among ...
Randomized Controlled Trial
The pharmacogenomics journal. 2016 Feb;16(1):71-8. DOI:10.1038/tpj.2015.17 2016
The role of Toll-like receptor 4 polymorphisms in vaccine immune response [0.03%]
toll样受体4多态性在疫苗免疫反应中的作用
P Pellegrino,F S Falvella,S Cheli et al.
P Pellegrino et al.
Toll-like receptors (TLRs) are a class of pattern recognition receptors that are deputed to recognise a range of molecular structures in pathogens. One of the most studied members of this family is the TLR4, which is essential for the signa...
Genome-wide association study of myelosuppression in non-small-cell lung cancer patients with platinum-based chemotherapy [0.03%]
基于铂类化疗的非小细胞肺癌患者的全基因组关联研究中的骨髓抑制作用
S Cao,S Wang,H Ma et al.
S Cao et al.
Platinum-induced myelosuppression severely impedes successful chemotherapy in non-small-cell lung cancer (NSCLC) patients. Hence, it is clinically important to identify the patients who are at high risk for severe toxicity to certain chemot...
Using local multiplicity to improve effect estimation from a hypothesis-generating pharmacogenetics study [0.03%]
利用局部多重性来改善假设生成型药物基因组学研究中效应估计的效果
W Zou,H Ouyang
W Zou
We propose a multiple estimation adjustment (MEA) method to correct effect overestimation due to selection bias from a hypothesis-generating study (HGS) in pharmacogenetics. MEA uses a hierarchical Bayesian approach to model individual effe...
Genetic variation, expression and ontogeny of sulfotransferase SULT2A1 in humans [0.03%]
人类硫酸转移酶SULT2A1的基因多态性、表达及其发育变化规律的研究
L Ekström,A Rane
L Ekström
Sulfotransferases (SULTs) are enzymes involved in the metabolism of several endogenous molecules. The activity and expression exhibit inter- and intra-individual variations due to age and genetic variation. The aims of this study were to co...
Genetic variants in DNA repair genes as potential predictive markers for oxaliplatin chemotherapy in colorectal cancer [0.03%]
DNA修复基因的遗传变异可能成为预测结直肠癌奥沙利铂化疗效果的标志物
E J Kap,P Seibold,S Richter et al.
E J Kap et al.
Oxaliplatin-based chemotherapy exerts its effects through generating DNA damage. Hence, genetic variants in DNA repair pathways could modulate treatment response. We used a prospective cohort of 623 colorectal cancer patients with stage II-...
Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate [0.03%]
RFC1、DHFR和MTHFR基因多态性对大剂量甲氨蝶呤治疗骨肉瘤患者的影响研究
S Jabeen,L Holmboe,G I G Alnæs et al.
S Jabeen et al.
Osteosarcoma patients are commonly treated with high doses of methotrexate (MTX). MTX is an analog of folate, which is essential for DNA synthesis. Genetic polymorphism at single nucleotide can be indicative to the prognostic outcome in pat...
Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial [0.03%]
急性冠脉综合征患者接受葡萄糖-胰岛素-钾(GIK)输注治疗反应的遗传修饰因子及其与IMMEDIATE试验中临床结果的关系研究
K L Ellis,Y Zhou,J R Beshansky et al.
K L Ellis et al.
Modifiers of response to glucose, insulin and potassium (GIK) infusion may affect clinical outcomes in acute coronary syndromes (ACS). In an Immediate Myocardial Metabolic Enhancement During Initial Assessment And Treatment In Emergency Car...
Clinical Trial
The pharmacogenomics journal. 2015 Dec;15(6):488-95. DOI:10.1038/tpj.2015.10 2015
A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients [0.03%]
一种新的UGT1标志物与转移性结直肠癌患者对伊立替康引起的严重中性粒细胞减少症的耐受性更好有关
S Chen,I Laverdiere,A Tourancheau et al.
S Chen et al.
The risk of severe irinotecan-induced neutropenia has been shown to be related to the UGT1 variant UGT1A1*28, which increases exposure to the potent metabolite SN-38. Our goal was to identify a novel UGT1 marker(s) using 28 haplotype-tagged...
Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients [0.03%]
CYP3A5和ABCB1基因多态性对亚洲语种人群索拉非尼暴露量、疗效及毒性的的影响研究
Y L Teo,H L Wee,X P Chue et al.
Y L Teo et al.
The objective of this study was to determine the effect of the CYP3A5 and ATP binding cassette subfamily B member 1 (ABCB1) single-nucleotide polymorphisms on the disposition of sunitinib and SU12662, on clinical response, and on the manife...