Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01 [0.03%]
对拉帕替尼引起的肝损伤进行全基因组综合评估，得出的单一代谢信号集中在已知的风险等位基因HLA-DRB1*07:01上
L R Parham,L P Briley,L Li et al.
L R Parham et al.
Lapatinib is associated with a low incidence of serious liver injury. Previous investigations have identified and confirmed the Class II allele HLA-DRB1*07:01 to be strongly associated with lapatinib-induced liver injury; however, the moder...
Clinical Trial
The pharmacogenomics journal. 2016 Apr;16(2):180-5. DOI:10.1038/tpj.2015.40 2016
A common polymorphism in the ABCB1 gene is associated with side effects of PGP-dependent antidepressants in a large naturalistic Dutch cohort [0.03%]
ABCB1基因中的一种常见多态性与PGP依赖性抗抑郁药的副作用有关，在一个大型荷兰自然队列中得到验证
P M Bet,E C Verbeek,Y Milaneschi et al.
P M Bet et al.
The drug efflux transporter permeability glycoprotein (PGP) and cytochrome P450 (CYP) 2C19 are important for eliminating antidepressants from the brain and body. The ABCB1 gene, encoding for PGP, and CYP2C19 gene have several variants that ...
Cost-effectiveness of one-time genetic testing to minimize lifetime adverse drug reactions [0.03%]
一次基因检测以减少终身药物不良反应的成本效果分析
O Alagoz,D Durham,K Kasirajan
O Alagoz
We evaluated the cost-effectiveness of one-time pharmacogenomic testing for preventing adverse drug reactions (ADRs) over a patient's lifetime. We developed a Markov-based Monte Carlo microsimulation model to represent the ADR events in the...
Genetic variation in uncontrolled childhood asthma despite ICS treatment [0.03%]
尽管使用了ICS治疗，未得到控制的儿童哮喘中仍存在遗传变异
M Leusink,S J H Vijverberg,L Koenderman et al.
M Leusink et al.
Genetic variation may partly explain asthma treatment response heterogeneity. We aimed to identify common and rare genetic variants associated with asthma that was not well controlled despite inhaled corticosteroid (ICS) treatment. Data of ...
Randomized Controlled Trial
The pharmacogenomics journal. 2016 Apr;16(2):158-63. DOI:10.1038/tpj.2015.36 2016
Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy [0.03%]
儿茶酚氧甲基转移酶的常见变异会影响接受全子宫切除术患者的病人自控镇痛泵使用和术后疼痛
E-C Tan,E C P Lim,C E Ocampo et al.
E-C Tan et al.
Catechol-O-methyltransferase (COMT) gene polymorphisms and haplotypes have been associated with both experimental and clinical pain phenotypes. In this prospective study, we investigated the association of three common polymorphisms with ex...
CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients [0.03%]
CYP2B6*6基因型和高依法韦恩血浆浓度但不是奈韦拉平与HIV-疟疾共感染患者低鲁美特林血浆暴露和治疗反应差有关
B A Maganda,O M S Minzi,E Ngaimisi et al.
B A Maganda et al.
We investigated the influence of efavirenz (EFV)- or nevirapine (NVP)-based antiretroviral therapy (ART) on lumefantrine plasma exposure in HIV-malaria-coinfected patients and implication of pharmacogenetic variations. A total of 269 HIV pa...
A subset of genetic susceptibility variants for colorectal cancer also has prognostic value [0.03%]
结直肠癌易感性基因变异子集也有预后价值
S Noci,M Dugo,F Bertola et al.
S Noci et al.
We investigated the possible influence of 86 single-nucleotide polymorphisms (SNPs), known to associate with the risk of colorectal cancer (CRC), on overall survival and time to recurrence (TTR) in 733 Italian CRC patients followed up for u...
A Kaplun,J D Hogan,F Schacherer et al.
A Kaplun et al.
The PharmacoGenomic Mutation Database (PGMD) is a comprehensive manually curated pharmacogenomics database. Two major sources of PGMD data are peer-reviewed literature and Food and Drug Administration (FDA) and European Medicines Agency (EM...
Prediction of treatment response to adalimumab: a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis [0.03%]
阿达木单抗治疗反应的预测：早期类风湿关节炎患者循环microRNA的双盲安慰剂对照研究
S B Krintel,C Dehlendorff,M L Hetland et al.
S B Krintel et al.
At least 30% of patients with rheumatoid arthritis (RA) do not respond to biologic agents, which emphasizes the need of predictive biomarkers. We aimed to identify microRNAs (miRNAs) predictive of response to adalimumab in 180 treatment-na...
Randomized Controlled Trial
The pharmacogenomics journal. 2016 Apr;16(2):141-6. DOI:10.1038/tpj.2015.30 2016
HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese [0.03%]
HLA-B*59:01位点与汉族人使用乙酰唑胺引起的史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症相关性研究
F Yang,J Xuan,J Chen et al.
F Yang et al.
Methazolamide is an intraocular pressure-lowering drug that is used in the treatment of glaucoma and other ophthalmologic abnormalities. The use of methazolamide has been shown to cause Stevens-Johnson syndrome (SJS) and toxic epidermal nec...