A collaborative force for precision medicine progress: the STRIPE pharmacogenomics conference series [0.03%]
精准医疗进展的协作力量：STRIPE药物基因组学大会系列
Sara L Rogers,J Shawn Jones,Ben L Kong et al.
Sara L Rogers et al.
Ben L Kong,Roseann S Donnelly,Amina Abubakar et al.
Ben L Kong et al.
Understanding general practitioner and pharmacist preferences for pharmacogenetic testing in primary care: a discrete choice experiment [0.03%]
理解初级保健中全科医生和药剂师对药物基因组检测偏好的实验研究：一种离散选择实验的方法
John H McDermott,Videha Sharma,Glenda M Beaman et al.
John H McDermott et al.
Pharmacogenetic testing in the United Kingdom's National Health Service (NHS) has historically been reactive in nature, undertaken in the context of single gene-drug relationships in specialist settings. Using a discrete choice experiment w...
Unveiling the association between HMG-CoA reductase inhibitors and bladder cancer: a comprehensive analysis using Mendelian randomization, animal models, and transcriptomics [0.03%]
他汀类药物与膀胱癌关联的再思考：孟德尔随机化、动物模型和转录组学的综合分析
Houyi Wei,Zhilong Li,Kaiyu Qian et al.
Houyi Wei et al.
This study utilized Mendelian randomization (MR) analysis and genome-wide association study (GWAS) data to investigate the association between commonly prescribed drugs and bladder cancer (BLCA) risk. Our results revealed that HMG CoA reduc...
Opioid use disorder risk alleles in self-reported assigned African American/Afro-Caribbean and European biogeographical genetic ancestry groups and in males and females [0.03%]
基于自我报告的非洲血统和欧亚血统群体以及男性和女性中的阿片类药物使用障碍风险等位基因
Jon E Sprague,Caroline E Freiermuth,Joshua Lambert et al.
Jon E Sprague et al.
The influence of genetic variants related to opioid use disorder (OUD) was evaluated using multiple logistic regression analysis in self-reported assigned African American/Afro-Caribbean and European biogeographical ancestry groups (BGAGs) ...
Contribution of plasma levels of VEGF-A and angiopoietin-2 in addition to a genetic variant in KCNAB1 to predict the risk of bevacizumab-induced hypertension [0.03%]
血管内皮生长因子A和血管生成素2的血浆水平及KCNAB1遗传多态性与贝伐单抗致高血压风险的关系研究
Julia C F Quintanilha,William Kevin Kelly,Federico Innocenti
Julia C F Quintanilha
Bevacizumab-induced hypertension poses a therapeutic challenge and identifying biomarkers for hypertension can enhance therapy safety. Lower plasma levels of VEGF-A, angiopoietin-2, and rs6770663 in KCNAB1 were previously associated with in...
Risk of anthracycline-induced cardiac dysfunction in adolescent and young adult (AYA) cancer survivors: role of genetic susceptibility loci [0.03%]
蒽环类药物诱发的心脏功能障碍在青少年和年轻成人癌症幸存者中的发病风险：易感基因位点的作用
Lily K Stafford,Xiaohui Tang,Amanda Brandt et al.
Lily K Stafford et al.
There is a known genetic susceptibility to anthracycline-induced cardiac dysfunction in childhood cancer survivors, but this has not been adequately shown in adolescent and young adult (AYA) patients. Our aim was to determine if the previou...
Predictive role of ITPA genetic variants in thiopurine-related myelotoxicity in Crohn's disease patients [0.03%]
ITPA基因变异在克罗恩病患者硫嘌呤相关骨髓毒性的预测作用
Juliana Salazar,Pau Riera,Jordi Gordillo et al.
Juliana Salazar et al.
Thiopurines, an effective therapy for Crohn's disease (CD), often lead to adverse events (AEs). Gene polymorphisms affecting thiopurine metabolism may predict AEs. This retrospective study in CD patients (n = 114) with TPMT activity > 5 Uni...
Nimodipine-associated standard dose reductions and neurologic outcomes after aneurysmal subarachnoid hemorrhage: the era of pharmacogenomics [0.03%]
尼莫地平相关标准剂量减少与动脉瘤性蛛网膜下腔出血后的神经结果：药物基因组学的时代
Adriana Vázquez-Medina,Marion T Turnbull,Courtney L James et al.
Adriana Vázquez-Medina et al.
Nimodipine, an L-type cerebroselective calcium channel antagonist, is the only drug approved by the US Food and Drug Administration for the neuroprotection of patients with aneurysmal subarachnoid hemorrhage (aSAH). Four randomized, placebo...
Pharmacokinetic and neuroimmune pharmacogenetic impacts on slow-release morphine cancer pain control and adverse effects [0.03%]
缓释吗啡癌痛镇痛及其不良反应的药代动力学和神经免疫药理遗传学效应
Daniel T Barratt,Pål Klepstad,Ola Dale et al.
Daniel T Barratt et al.
The aim was to determine if opioid neuroimmunopharmacology pathway gene polymorphisms alter serum morphine, morphine-3-glucuronide and morphine-6-glucuronide concentration-response relationships in 506 cancer patients receiving controlled-r...