L Smiderle,M Fiegenbaum,M H Hutz et al.
L Smiderle et al.
Lipid-lowering therapy has shown a high degree of variability in clinical response and there is evidence that the variability in drug response between individuals is due to genetic factors. Thirteen single nucleotide polymorphisms (SNPs) wi...
Comparative Study
The pharmacogenomics journal. 2016 Nov;16(6):507-513. DOI:10.1038/tpj.2015.60 2016
Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population [0.03%]
中国汉族人群抗精神病药物治疗反应的遗传相关性研究
Q Xu,X Wu,M Li et al.
Q Xu et al.
Schizophrenia is a widespread mental disease with a prevalence of about 1% in the world population. Continuous long-term treatment is required to maintain social functioning and prevent symptom relapse of schizophrenia patients. However, th...
Attitudes of clinicians following large-scale pharmacogenomics implementation [0.03%]
大规模药物基因组学实施后的临床医生的态度
J F Peterson,J R Field,Y Shi et al.
J F Peterson et al.
Clinician attitudes toward multiplexed genomic testing may be vital to the success of translational programs. We surveyed clinicians at an academic medical center about their views on a large pharmacogenomics implementation, the PREDICT (Ph...
AGXT and ERCC2 polymorphisms are associated with clinical outcome in metastatic colorectal cancer patients treated with 5-FU/oxaliplatin [0.03%]
胸苷酸合成酶和切除修复交叉互补基因2多态性与接受5-氟尿嘧啶/奥沙利铂治疗的转移性结直肠癌患者的临床转归相关性研究
J B Kjersem,M Thomsen,T Guren et al.
J B Kjersem et al.
The objective of the study was to investigate whether specific single nucleotide polymorphisms (SNPs) with influence on drug transport, biotransformation and repair mechanisms are associated with treatment outcome and toxicity in metastatic...
Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors [0.03%]
有机阴离子转运蛋白7/SLC22A9（普伐他汀摄取转运体）的肝表达变异：遗传和调控因素的影响
A Emami Riedmaier,O Burk,B A C van Eijck et al.
A Emami Riedmaier et al.
Human organic anion transporter 7 (OAT7, SLC22A9) is a hepatic transport protein poorly characterized so far. We therefore sought to identify novel OAT7 substrates and factors contributing to variable hepatic OAT7 expression. Using OAT7-exp...
Genotype-phenotype correlations in 5-fluorouracil metabolism: a candidate DPYD haplotype to improve toxicity prediction [0.03%]
5-氟尿嘧啶代谢中的基因型表型相关性：一个改善毒性预测的DPYD单体型
G Gentile,A Botticelli,L Lionetto et al.
G Gentile et al.
5-Fluorouracil is among the most widely used anticancer drug, but a fraction of treated patients develop severe toxicity, with potentially lethal injuries. The predictive power of the available pretreatment assays, used to identify patients...
Paradoxical psoriasiform reactions to anti-TNFα drugs are associated with genetic polymorphisms in patients with psoriasis [0.03%]
遗传多态性与银屑病患者使用抗TNFα药物产生矛盾的银屑病样反应有关
T Cabaleiro,R Prieto-Pérez,R Navarro et al.
T Cabaleiro et al.
Paradoxical psoriasiform reactions to anti-tumor necrosis factor α (TNFα) agents have been described. We aimed to study the association between these reactions and polymorphisms in genes previously associated with psoriasis or other autoi...
Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [0.03%]
卡铂/紫杉醇引起的胃肠毒性：对SCOTROC1试验的药物基因组学研究
Y J He,S J Winham,J M Hoskins et al.
Y J He et al.
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity. A candidate gene...
Clinical Trial
The pharmacogenomics journal. 2016 Jun;16(3):243-8. DOI:10.1038/tpj.2015.52 2016
A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough [0.03%]
一项全基因组关联研究发现KCNIP4变异与ACE抑制剂引起的咳嗽相关
J D Mosley,C M Shaffer,S L Van Driest et al.
J D Mosley et al.
The most common side effect of angiotensin-converting enzyme inhibitor (ACEi) drugs is cough. We conducted a genome-wide association study (GWAS) of ACEi-induced cough among 7080 subjects of diverse ancestries in the Electronic Medical Reco...
Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits [0.03%]
药物基因组多态性比与其他二分复杂表型相关联的遗传多态性具有更大的效应大小
J C Maranville,N J Cox
J C Maranville
It has been suggested that pharmacogenomic phenotypes are influenced by genetic variants with larger effect sizes than other phenotypes, such as complex disease risk. This is presumed to reflect the fact that relevant environmental factors ...
Comparative Study
The pharmacogenomics journal. 2016 Aug;16(4):388-92. DOI:10.1038/tpj.2015.47 2016