Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses, and drug-drug interactions [0.03%]
SLC22A1多态性变异在药物处置、治疗反应和药物相互作用中的作用
C Arimany-Nardi,H Koepsell,M Pastor-Anglada
C Arimany-Nardi
The SCL22A1 gene encodes the broad selectivity transporter hOCT1. hOCT1 is expressed in most epithelial barriers thereby contributing to drug pharmacokinetics. It is also expressed in different drug target cells, including immune system cel...
Interethnic variation of CYP2C19 alleles, 'predicted' phenotypes and 'measured' metabolic phenotypes across world populations [0.03%]
世界人口中的跨族裔CYP2C19等位基因、"预测"表型和"检测到"的代谢表型的差异性分析
I Fricke-Galindo,C Céspedes-Garro,F Rodrigues-Soares et al.
I Fricke-Galindo et al.
The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and CYP2C19 metabolic phenotypes ('predicted' from genotypes and 'measured' with a probe drug) among healthy volunteers from different ethnic groups and geo...
Estrogen receptor-beta genetic variations and overall survival in patients with locally advanced gastric cancer [0.03%]
胃癌患者雌激素受体-β遗传变异与总体生存率的关系研究
Y Sunakawa,S Cao,M D Berger et al.
Y Sunakawa et al.
Estrogen has been shown not only to reduce the incidence of colorectal cancer but also gastric cancer (GC). Polymorphisms in estrogen receptor β gene, ESR2, correlate with colorectal cancer survival. To better understand the role of ESR2 i...
Multicenter Study
The pharmacogenomics journal. 2017 Jan;17(1):36-41. DOI:10.1038/tpj.2015.77 2017
Complement 3 and metabolic syndrome induced by clozapine: a cross-sectional study and retrospective cohort analysis [0.03%]
补体3和氯氮平诱导的代谢综合征：横断面研究和回顾性队列分析
C Zhang,Y Zhang,J Cai et al.
C Zhang et al.
Metabolic syndrome (MetS) is considered to be an adverse effect of long-term treatment with atypical antipsychotics, particularly clozapine. There is strong evidence that the activation of inflammatory pathways interferes with normal metabo...
Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1 [0.03%]
基因拷贝数变异分析揭示CYP2E1表达量的剂量非敏感性
R Tremmel,K Klein,S Winter et al.
R Tremmel et al.
Gene copy number variants (CNVs) of CYP2E1 have been described but not functionally characterized. Here we investigated effects of CNVs on hepatic and lymphoblastoid CYP2E1 expression. Using available single-nuleotide polymorphism microarra...
Computational discovery of transcription factors associated with drug response [0.03%]
计算发现与药物反应相关的转录因子
C Hanson,J Cairns,L Wang et al.
C Hanson et al.
This study integrates gene expression, genotype and drug response data in lymphoblastoid cell lines with transcription factor (TF)-binding sites from ENCODE (Encyclopedia of Genomic Elements) in a novel methodology that elucidates regulator...
Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort [0.03%]
南非洲人群样本中CYP2D6预测表型和测定表型的药物基因组学对比分析
T M Dodgen,C De J Labuschagne,A van Schalkwyk et al.
T M Dodgen et al.
The relationship between genetic variation in CYP2D6 and variable drug response represents a potentially powerful pharmacogenetic tool. However, little is known regarding this relationship in the genetically diverse South African population...
A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病对吸入β2激动剂的反应的全基因组分析
M Hardin,M H Cho,M-L McDonald et al.
M Hardin et al.
Short-acting β2-agonist bronchodilators are the most common medications used in treating chronic obstructive pulmonary disease (COPD). Genetic variants determining bronchodilator responsiveness (BDR) in COPD have not been identified. We pe...
Meta-Analysis
The pharmacogenomics journal. 2016 Aug;16(4):326-35. DOI:10.1038/tpj.2015.65 2016
NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia [0.03%]
台湾儿童急性淋巴细胞白血病患者中巯基嘌呤不耐受与NUDT15基因多态性的关系研究
D-C Liang,C-P Yang,H-C Liu et al.
D-C Liang et al.
A recent study identified a variant of the NUDT15 gene (rs116855232 C>T) associated with intolerance to thiopurine in Korean patients with Crohn's disease. This study prompted us to substantiate the finding in a Taiwanese population. Four h...
Predictive markers in elderly patients with estrogen receptor-positive breast cancer treated with aromatase inhibitors: an array-based pharmacogenetic study [0.03%]
绝经后ER阳性乳腺癌患者使用芳香化酶抑制剂治疗的预后分子标志的芯片基因研究
E Rumiato,A Brunello,S Ahcene-Djaballah et al.
E Rumiato et al.
So far, no reliable predictive clinicopathological markers of response to aromatase inhibitors (AIs) have been identified, and little is known regarding the role played by host genetics. To identify constitutive predictive markers, an array...
Multicenter Study
The pharmacogenomics journal. 2016 Nov;16(6):525-529. DOI:10.1038/tpj.2015.73 2016