Genetic markers predicting sulphonylurea treatment outcomes in type 2 diabetes patients: current evidence and challenges for clinical implementation [0.03%]
预测2型糖尿病患者磺脲类药物治疗结局的遗传标志物：现有证据及临床应用挑战
N K Loganadan,H Z Huri,S R Vethakkan et al.
N K Loganadan et al.
The clinical response to sulphonylurea, an oral antidiabetic agent often used in combination with metformin to control blood glucose in type 2 diabetes (T2DM) patients, has been widely associated with a number of gene polymorphisms, particu...
Genetic variants associated with colorectal brain metastases susceptibility and survival [0.03%]
与结直肠脑转移易感性和生存相关的遗传变异体
S Stremitzer,A S Berghoff,N B Volz et al.
S Stremitzer et al.
Colorectal brain metastases (BM) are rare (1-2%) and a late-stage disease manifestation. Molecular mechanisms for BM development are not well understood. We tested whether variants within genes involved in overcoming the blood-brain barrier...
Genotype-guided tacrolimus dosing in African-American kidney transplant recipients [0.03%]
基于基因型的他克莫司剂量指导在非洲裔美国肾移植受者中的应用
K Sanghavi,R C Brundage,M B Miller et al.
K Sanghavi et al.
Tacrolimus is dependent on CYP3A5 enzyme for metabolism. Expression of the CYP3A5 enzyme is controlled by several alleles including CYP3A5*1, CYP3A5*3, CYP3A5*6 and CYP3A5*7. African Americans (AAs) have on average higher tacrolimus dose re...
Observational Study
The pharmacogenomics journal. 2017 Jan;17(1):61-68. DOI:10.1038/tpj.2015.87 2017
Impact of GSTM1, GSTT1 and GSTP1 gene polymorphism and risk of ARV-associated hepatotoxicity in HIV-infected individuals and its modulation [0.03%]
GSTM1、GSTT1和GSTP1基因多态性对HIV感染者核苷类逆转录酶抑制剂肝毒性的易感性及调节作用的影响研究
H O Singh,S Lata,M Angadi et al.
H O Singh et al.
Glutathione S-transferase (GST) family is involved in a two-stage detoxification process of a wide range of environmental toxins, carcinogen and antiretroviral (ARV) therapy (ART) drugs. The aim of this study is to describe the impact of ge...
Pharmacogenetic study of long-term response to interferon-β treatment in multiple sclerosis [0.03%]
长期干扰素β治疗多发性硬化症的药物基因组学研究
F Clarelli,G Liberatore,M Sorosina et al.
F Clarelli et al.
The aim of the study is the identification of genetic factors that influence the long-term response to interferon-β (IFNβ) (4-year follow-up). We performed a genome-wide association study in 337 IFNβ-treated Italian multiple sclerosis pa...
Meta-Analysis
The pharmacogenomics journal. 2017 Jan;17(1):84-91. DOI:10.1038/tpj.2015.85 2017
J Liu,H H Jiang,D K Wu et al.
J Liu et al.
The adverse reactions of warfarin that were found mainly occurred in the first month. This study was carried out to observe the effect of gene polymorphisms on the warfarin therapy at the initial stage. Four-hundred and sixty Chinese patien...
CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation [0.03%]
CRTC2多态性作为实体器官移植患者代谢综合征发病的风险因素
L Quteineh,P-Y Bochud,D Golshayan et al.
L Quteineh et al.
Metabolic syndrome after transplantation is a major concern following solid organ transplantation (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. The effect of CRTC2 polymorphisms on new-onset di...
Pharmacogenetics and induction/consolidation therapy toxicities in acute lymphoblastic leukemia patients treated with AIEOP-BFM ALL 2000 protocol [0.03%]
药理基因组学和AIEOP-BFM ALL 2000方案急性淋巴细胞白血病患者诱导/巩固治疗毒性之间的关系
R Franca,P Rebora,N Bertorello et al.
R Franca et al.
Drug-related toxicities represent an important clinical concern in chemotherapy, genetic variants could help tailoring treatment to patient. A pharmacogenetic multicentric study was performed on 508 pediatric acute lymphoblastic leukemia pa...
A systematic review and meta-analysis of the impact of WT1 polymorphism rs16754 in the effectiveness of standard chemotherapy in patients with acute myeloid leukemia [0.03%]
WT1基因多态性rs16754在急性髓系白血病标准化疗疗效中作用的系统评价和meta分析研究
J E Megías-Vericat,M J Herrero,L Rojas et al.
J E Megías-Vericat et al.
The polymorphism rs16754 of the WT1 gene has been described as a possible prognostic marker in different acute myeloid leukemia (AML) cohorts; however, it is not supported by all the studies. We performed the first meta-analysis evaluating ...
Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial [0.03%]
在IMMEDIATE试验中，葡萄糖-胰岛素-钾(GIK)治疗后循环未酯化脂肪酸水平变化的相关常见变异位点分析
K L Ellis,Y Zhou,L Rodriguez-Murillo et al.
K L Ellis et al.
Glucose-insulin-potassium (GIK) therapy may promote a shift from oxygen-wasteful free fatty acid (FFA) metabolism to glycolysis, potentially reducing myocardial damage during ischemia. Genetic variation associated with FFA response to GIK w...
Randomized Controlled Trial
The pharmacogenomics journal. 2017 Jan;17(1):76-83. DOI:10.1038/tpj.2015.84 2017