A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMETTM Plus platform [0.03%]
采用DMET Plus平台研究健康志愿者他克莫司药代动力学的药物基因组学研究报告
Y Choi,F Jiang,H An et al.
Y Choi et al.
Genetic association studies on the pharmacokinetics of tacrolimus have reported conflicting results, except for the role of the CYP3A5*3 polymorphism. The objective of this study was to identify genetic variants affecting the pharmacokineti...
Randomized Controlled Trial
The pharmacogenomics journal. 2017 Mar;17(2):174-179. DOI:10.1038/tpj.2015.99 2017
The GRM7 gene, early response to risperidone, and schizophrenia: a genome-wide association study and a confirmatory pharmacogenetic analysis [0.03%]
GRM7基因、利培酮早期效应及精神分裂症的遗传相关性研究：一项全基因组关联研究和一项确证性药物基因组学分析
E Sacchetti,C Magri,A Minelli et al.
E Sacchetti et al.
The search for biomarkers of response to antipsychotic medications is hindered by difficulties inherent in the topic or related to persistent methodological difficulties, such as high rates of anticipated discontinuation and consequent dist...
Randomized Controlled Trial
The pharmacogenomics journal. 2017 Mar;17(2):146-154. DOI:10.1038/tpj.2015.90 2017
A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate [0.03%]
纵向研究GNB3 C825T多态性与双相情感障碍二期患者服用丙戊酸钠引起代谢紊乱的关联性研究
P S Chen,H H Chang,C-C Huang et al.
P S Chen et al.
This longitudinal study aimed to investigate the associations between the polymorphisms of guanine nucleotide-binding protein subunit β-3 (GNB3) C825T and metabolic disturbance in bipolar II disorder (BP-II) patients being treated with val...
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines [0.03%]
人组织和淋巴母细胞系的药理基因转录组变异
A Chhibber,C E French,S W Yee et al.
A Chhibber et al.
Variation in the expression level and activity of genes involved in drug disposition and action ('pharmacogenes') can affect drug response and toxicity, especially when in tissues of pharmacological importance. Previous studies have relied ...
A genetic factor associated with low final bone mineral density in children after a long-term glucocorticoids treatment [0.03%]
与长期糖皮质激素治疗后儿童最终低骨矿密度相关的遗传因素
H-W Park,S Tse,W Yang et al.
H-W Park et al.
Treatment with glucocorticoids is associated with lower bone mineral density (BMD). We performed a genome-wide association study to analyze interactive effects between genotypes and cumulative dose of prednisone (PD) over 4.3 years of follo...
Randomized Controlled Trial
The pharmacogenomics journal. 2017 Mar;17(2):180-185. DOI:10.1038/tpj.2015.92 2017
Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder [0.03%]
注意缺陷多动障碍中哌甲酯治疗反应和耐受性的药物基因组学研究
M Pagerols,V Richarte,C Sánchez-Mora et al.
M Pagerols et al.
Methylphenidate (MPH) is the most frequently used pharmacological treatment in children with attention-deficit/hyperactivity disorder. However, a considerable interindividual variability exists in clinical outcome, which may reflect underly...
Sunitinib-induced hypertension in CYP3A4 rs4646437 A-allele carriers with metastatic renal cell carcinoma [0.03%]
CYP3A4 rs4646437 A-allele携带者转移性肾细胞癌患者服用索拉菲尼引起高血压
M H Diekstra,A Belaustegui,J J Swen et al.
M H Diekstra et al.
The single nucleotide polymorphism (SNP) rs4646437G>A in CYP3A4 was suggested to be related to sunitinib toxicity. Our objective was to perform an in-depth investigation of the association between this SNP and sunitinib toxicity and efficac...
Observational Study
The pharmacogenomics journal. 2017 Jan;17(1):42-46. DOI:10.1038/tpj.2015.100 2017
Impact of germline and somatic missense variations on drug binding sites [0.03%]
遗传系和体细胞错义变异对药物结合位点的影响
C Yan,N Pattabiraman,J Goecks et al.
C Yan et al.
Advancements in next-generation sequencing (NGS) technologies are generating a vast amount of data. This exacerbates the current challenge of translating NGS data into actionable clinical interpretations. We have comprehensively combined ge...
ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout [0.03%]
ABCG2功能丧失型多态性预测痛风患者对别嘌醇反应不佳
R L Roberts,M C Wallace,A J Phipps-Green et al.
R L Roberts et al.
Many patients fail to achieve the recommended serum urate (SU) target (300 mgd-1.
ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children [0.03%]
ABCC3基因变异与儿童术后阿片类药物呼吸抑制及药代动力学的关系
V Chidambaran,R Venkatasubramanian,X Zhang et al.
V Chidambaran et al.
Respiratory depression (RD) is a serious side effect of morphine and detrimental to effective analgesia. We reported that variants of the ATP binding cassette gene ABCC3 (facilitates hepatic morphine metabolite efflux) affect morphine metab...
Observational Study
The pharmacogenomics journal. 2017 Mar;17(2):162-169. DOI:10.1038/tpj.2015.98 2017