Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population [0.03%]
HLA-B*15:13和HLA-B*15:02与马来人种群中的苯妥英钠引起严重皮肤不良反应的关系
C-C Chang,C-C Ng,C-L Too et al.
C-C Chang et al.
Phenytoin (PHT) is a common cause of severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Although HLA-B*15...
Genetic prediction of long-term survival after neoadjuvant chemoradiation in locally advanced esophageal cancer [0.03%]
新辅助化学免疫治疗后局部晚期食管癌患者长期生存的遗传预测
M Gusella,S Giacopuzzi,L Bertolaso et al.
M Gusella et al.
Candidate genes involved in DNA repair, 5-fluorouracil metabolism and drug detoxification were genotyped in 124 patients receiving neoadjuvant chemoradiation treatment for locally advanced esophageal cancer and their predictive role for lon...
P R Bushel,R D Fannin,K Gerrish et al.
P R Bushel et al.
Acetaminophen can adversely affect the liver especially when overdosed. We used whole blood as a surrogate to identify genes as potential early indicators of an acetaminophen-induced response. In a clinical study, healthy human subjects wer...
Randomized Controlled Trial
The pharmacogenomics journal. 2017 Jun;17(3):230-236. DOI:10.1038/tpj.2016.8 2017
A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials [0.03%]
一项有关静脉注射呋塞米治疗心力衰竭的药物基因组学研究：三项临床试验的meta分析
S de Denus,J L Rouleau,D L Mann et al.
S de Denus et al.
We conducted a meta-analysis of pharmacogenomic substudies of three randomized trials conducted in patients with decompensated heart failure (HF) that were led by National Heart Lung and Blood Institute (NHLBI)-funded HF Network to test the...
Meta-Analysis
The pharmacogenomics journal. 2017 Mar;17(2):192-200. DOI:10.1038/tpj.2016.4 2017
Glycolysis gene expression analysis and selective metabolic advantage in the clinical progression of colorectal cancer [0.03%]
临床结直肠癌进展中的糖酵解基因表达分析及代谢优势的选择性分析
F Graziano,A Ruzzo,E Giacomini et al.
F Graziano et al.
Production of lactate even in the presence of sufficient levels of oxygen (aerobic glycolysis) seems the prevalent energy metabolism pathway in cancer cells. The analysis of altered expression of effectors causing redirection of glucose met...
Multicenter Study
The pharmacogenomics journal. 2017 Jun;17(3):258-264. DOI:10.1038/tpj.2016.13 2017
Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner [0.03%]
他汀类药物诱导的INSIG1在淋巴母细胞样细胞系中的表达变化以性别特异性的方式与血浆甘油三酯应答相关
E Theusch,K Kim,K Stevens et al.
E Theusch et al.
Statins are widely prescribed to lower plasma low-density lipoprotein (LDL) cholesterol levels. They also modestly reduce plasma triglyceride (TG), an independent cardiovascular disease risk factor, in most people. The mechanism and inter-i...
Controlled Clinical Trial
The pharmacogenomics journal. 2017 Jun;17(3):222-229. DOI:10.1038/tpj.2016.12 2017
Health regulatory communications of well-established safety-related pharmacogenomics associations in six developed countries: an evaluation of alignment [0.03%]
六大发达国家建立完善的药物基因组学关联的健康监管沟通评估：一致性评价
W C Tan-Koi,Evelyn S H Lim,Y Y Teo
W C Tan-Koi
Recommendations on genetic testing are typically conveyed by drug regulatory authorities through drug labels, which are legal requirements for market authorization of drugs. We conducted a cross-sectional study of drug labels focusing on th...
Multicenter Study
The pharmacogenomics journal. 2017 Mar;17(2):121-127. DOI:10.1038/tpj.2016.5 2017
The effect of genetic variation in PCSK9 on the LDL-cholesterol response to statin therapy [0.03%]
PCSK9基因多态性对他汀类药物治疗降低LDL胆固醇疗效的影响研究
Q Feng,W Q Wei,C P Chung et al.
Q Feng et al.
Statins (HMG-CoA reductase inhibitors) lower low-density lipoprotein cholesterol (LDL-C) and prevent cardiovascular disease. However, there is wide individual variation in LDL-C response. Drugs targeting proprotein convertase subtilin/kexin...
Role of the C1858T polymorphism of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in children and adolescents with type 1 diabetes [0.03%]
蛋白酪氨酸磷酸酶非受体型22(C1858T)多态性在1型糖尿病儿童及青少年中的作用研究
A Blasetti,C Di Giulio,S Tumini et al.
A Blasetti et al.
In recent years, increasing interest has been devoted to the susceptibility gene polymorphisms in type 1 diabetes (T1D) as well as in other autoimmune diseases. Among these, a nucleotide polymorphism of the gene encoding for the protein tyr...
The effects of rosuvastatin on lipid-lowering, inflammatory, antioxidant and fibrinolytics blood biomarkers are influenced by Val16Ala superoxide dismutase manganese-dependent gene polymorphism [0.03%]
Val16Ala锰依赖型超氧化物歧化酶基因多态性影响鲁伐斯塔汀对降脂、抗炎、抗氧化和纤溶系统血液生物标志物的作用
T Duarte,I B M da Cruz,F Barbisan et al.
T Duarte et al.
Rosuvastatin is a cholesterol-lowering drug that also attenuates the inflammatory process and oxidative stress via the reduction of superoxide anion production. Superoxide anions are metabolized by manganese-dependent superoxide dismutase (...