Variant alleles in factor V, prothrombin, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase and risk of thromboembolism in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab [0.03%]
因化疗联合贝伐单抗新诊断转移性结直肠癌患者凝血因子V、凝血酶原、纤溶酶激活物抑制剂-1以及亚甲基四氢叶酸还原酶变异等位基因和血栓形成风险的关系研究
F S Falvella,C Cremolini,R Miceli et al.
F S Falvella et al.
Single-nucleotide polymorphisms (SNPs) related to hereditary thrombophilia were investigated as risk factors for thromboembolism in cancer patients. Their effect in metastatic colorectal cancer (mCRC) has never been explored so far. Our aim...
Observational Study
The pharmacogenomics journal. 2017 Jul;17(4):331-336. DOI:10.1038/tpj.2016.22 2017
The impact of ABCC11 polymorphisms on the risk of early-onset fluoropyrimidine toxicity [0.03%]
ABCC11多态性对氟尿嘧啶类药物早期毒性的风险影响研究
S Hamzic,N Wenger,T K Froehlich et al.
S Hamzic et al.
A missense variant (c.1637C>T, T546M) in ABCC11 encoding the MRP8 (multidrug resistance protein 8), a transporter of 5-fluorodeoxyuridine monophosphate, has been associated with an increased risk of 5-fluorouracil-related severe leukopenia....
Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study [0.03%]
干扰素β治疗多发性硬化症患者的基因组关联研究
S Mahurkar,M Moldovan,V Suppiah et al.
S Mahurkar et al.
Up to 50% of multiple sclerosis (MS) patients do not respond to interferon-beta (IFN-β) treatment and determination of response requires lengthy clinical follow-up of up to 2 years. Response predictive genetic markers would significantly i...
Association of thymidylate synthase polymorphisms with the tumor response to preoperative chemoradiotherapy in rectal cancer: a systematic review and meta-analysis [0.03%]
胸苷酸合成酶多态性与直肠癌新辅助化放疗疗效关系的系统评价和meta分析
Y C Yang,G C Wu,L Jin et al.
Y C Yang et al.
Preoperative chemoradiotherapy (pCRT) followed by surgery is currently the standard therapy for patients with locally advanced rectal cancer. It is very important to develop biomarkers to prior identify the patients who have a higher likeli...
W Qiao,J Wang,B S Pullman et al.
W Qiao et al.
KIR2DS2 as predictor of thrombocytopenia secondary to pegylated interferon-alpha therapy [0.03%]
KIR2DS2预测聚乙二醇化干扰素-α治疗继发血小板减少性反应的能力
A Rivero-Juarez,R Gonzalez,M Frias et al.
A Rivero-Juarez et al.
Our aim was to evaluate the killer cell immunoglobulin-like receptors (KIRs) as a marker for the development of thrombocytopenia secondary to Peg-interferon (IFN) therapy in a cohort of human immunodeficiency virus (HIV)/hepatitis C virus (...
Integrated Drug Expression Analysis for leukemia: an integrated in silico and in vivo approach to drug discovery [0.03%]
综合药物表达分析在白血病研究中的应用：一种结合计算和实验的方法发现新药
M H Ung,C-H Sun,C-W Weng et al.
M H Ung et al.
Screening for drug compounds that exhibit therapeutic properties in the treatment of various diseases remains a challenge even after considerable advancements in biomedical research. Here, we introduce an integrated platform that exploits g...
Pharmacogenetics of ABCB5, ABCC5 and RLIP76 and doxorubicin pharmacokinetics in Asian breast cancer patients [0.03%]
ABCB5、ABCC5和RLIP76的药物基因组学与亚洲乳腺癌患者的多柔比星药代动力学关系研究
S Lal,N Sutiman,L L Ooi et al.
S Lal et al.
This study investigated the impact of ABCB5, ABCC5 and RLIP76 polymorphisms on doxorubicin pharmacokinetics in Asian breast cancer patients (N=62). Direct sequencing was performed to screen for previously identified ABCC5 polymorphisms as w...
A potentially functional polymorphism in ABCG2 predicts clinical outcome of non-small cell lung cancer in a Chinese population [0.03%]
ABCG2基因多态性预测非小细胞肺癌临床结局在中国人中的功能研究
J Sun,M Zhu,W Shen et al.
J Sun et al.
ABCG2, CD133 and CD117 are pivotal markers of cancer stem cell, which are involved in carcinogenesis and cancer progression. The expression of these genes has been reported to be associated with the development and progression of many cance...
Genetic contribution of CYP1A1 variant on treatment outcome in epilepsy patients: a functional and interethnic perspective [0.03%]
药代动力学候选基因CYP1A1多态性与癫痫疗效的关系研究：功能及 interracial角度分析
P Talwar,N Kanojia,S Mahendru et al.
P Talwar et al.
CYP1A1 gene is involved in estrogen metabolism, and previously, we have reported association of variant rs2606345 with altered anti-epileptic drugs (AED) response in North Indian women with epilepsy (WWE). The present study aims to replicat...
Comparative Study
The pharmacogenomics journal. 2017 Jun;17(3):242-251. DOI:10.1038/tpj.2016.1 2017