Pharmacogenomics to optimise psychotropic prescribing: a survey of mental health professionals' perceptions, knowledge, and educational needs [0.03%]
药物基因组学在优化精神活性药物处方中的应用：调查心理健康专业人员的看法、知识和教育需求
Daniele Panconesi,Stephen Murtough,Marius Cotic et al.
Daniele Panconesi et al.
A survey was conducted to determine attitudes, knowledge, and educational needs of mental health professionals regarding pharmacogenomics. We recruited 128 clinicians working in mental health in England, and we assessed their experiences us...
Combined Role of CYP3A4 and CYP3A5 genetic variants in tacrolimus dose-adjusted trough levels: a clinical retrospective study in kidney transplant patients [0.03%]
肾脏移植患者他克莫司调整剂量的血药浓度与CYP3A4和CYP3A5基因多态性的临床相关性研究
Anna Tsironi,Effrosyni Mendrinou,Stavroula Siamoglou et al.
Anna Tsironi et al.
Tacrolimus, a calcineurin inhibitor with a narrow therapeutic index, requires precise dosing to optimize efficacy and minimize adverse effects in kidney transplant recipients. Although CYP3A5 genetic variants influence tacrolimus pharmacoki...
Comparative analysis of point-of-care bedside cyp2c19-testing guided anti-platelet therapy versus conventional therapies for cardiovascular diseases: a systematic review and meta-analysis [0.03%]
基于护理点鸟苷酸环化酶活性床旁CYP2C19基因分型指导的抗血小板治疗与传统疗法治疗心血管疾病的比较分析：系统综述和meta分析
Mohammed Khattab,Mohamed Baguneid,George P Patrinos et al.
Mohammed Khattab et al.
Genetic variation in CYP2C19 is linked to variable efficacy in antiplatelet therapies like clopidogrel. Patients with CYP2C19*2 and *3 loss of function alleles show reduced enzyme function, leading to lower active drug levels and higher ris...
mLeveraging genetic correlations to prioritize drug groups for repurposing in type 2 diabetes [0.03%]
利用遗传相关性优先确定2型糖尿病药物再定位的药物组
Astrid Johannesson Hjelholt,Tahereh Gholipourshahraki,Zhonghao Bai et al.
Astrid Johannesson Hjelholt et al.
Type 2 diabetes (T2D) is a complex, polygenic disease with substantial health impact. Despite extensive genome-wide association studies (GWAS) identifying risk loci, therapeutic translation remains limited. We applied a Bayesian Linear Regr...
Genetic and pharmacokinetic factors associated with imatinib-induced toxicities in gastrointestinal stromal tumors [0.03%]
与胃肠间质瘤伊马替尼诱导的毒性相关的影响遗传和药代动力学因素
Wei Zhuang,Yi Zeng,Xinping Lin et al.
Wei Zhuang et al.
Imatinib is associated with significant toxicities, including myelosuppression, oedema, and hypersensitivity, with considerable interpatient variability. Pharmacokinetic and pharmacogenomic factors contribute, but comprehensive biomarkers a...
Mitochondrial DNA variants and susceptibility to anti-tuberculosis drug-induced liver injury in Korean patients [0.03%]
线粒体DNA变异与韩国结核病患者抗结核药物性肝损伤易感性的关联研究
Vinh Hoa Pham,Sang-Heon Kim,Young-Koo Jee et al.
Vinh Hoa Pham et al.
It has been proposed that mitochondrial DNA variations can affect mitochondrial function, increasing the risk of drug-induced liver injury. This study aims to explore the association between mitochondrial DNA (mtDNA) variants and anti-tuber...
Anna Shteto,Jawad Boulahfa,Adrien Etcheto et al.
Anna Shteto et al.
Predictive safety risk biomarkers for drug-induced liver injury (DILI) are critically needed to enhance patient risk stratification and minimize adverse outcomes. This study aims to identify genomic markers associated with increased mortali...
Evaluation of experiential teaching approaches to enhance pharmacy students' confidence and knowledge in pharmacogenomics [0.03%]
体验式教学在提升药学学生精准用药知识及自信度的效果评估研究
Ruby Soueid,Toni J F Michael,Pete Yeap et al.
Ruby Soueid et al.
Pharmacogenomic services are commonly pharmacist-led, yet pharmacists report poor knowledge and confidence in application. This study evaluated an experiential teaching approach to enhance students' confidence and knowledge in pharmacogenom...
Genome-wide screening of pharmacogenomic biomarkers in jordanian patients with genetic disorders [0.03%]
约旦遗传病患者药物基因组生物标志物的全基因组筛选
Yazun Jarrar,Nancy Hakooz,Dina Abu Hashem et al.
Yazun Jarrar et al.
Introduction: Pharmacogenomics (PGx) testing aims to identify the most appropriate drug and dose for individual patients based on their genetic profiles. In Jordan, patients with genetic disorders often use multiple medic...
Wrenda Teeple,Jeffrey A Shaman,Tootie Tatum et al.
Wrenda Teeple et al.