Meta-analysis and review of in silico methods in drug discovery - part 1: technological evolution and trends from big data to chemical space [0.03%]
基于计算的药物发现方法的荟萃分析与总结（一）：大数据时代的药物发现技术的发展和趋势综述
Arife Uzundurukan,Mark Nelson,Christopher Teske et al.
Arife Uzundurukan et al.
This review offers an overview of advanced in silico methods crucial for drug discovery, emphasizing their integration with data science, and investigates the effectiveness of data science, machine learning, and artificial intelligence via ...
A feasibility study on implementing pre-emptive pharmacogenomics testing in outpatient clinics in Singapore (IMPT study) [0.03%]
在新加坡的门诊诊所实施预防性药物基因组学检测的可行性研究（IMPT研究）
Fiona Fj Ng,Rashmi Verma,Levana Sani et al.
Fiona Fj Ng et al.
In view of the limited data related to preemptive pharmacogenomics (PGx) testing in the primary care setting, we designed a study to assess the feasibility of implementing preemptive PGx services at outpatient clinics, with the aim to asses...
Cost-utility analysis of pharmacogenomics-guided tacrolimus treatment of Slovenian patients undergoing kidney transplantation in the U-PGx PREPARE study [0.03%]
U-PGx PREPARE研究中基于药理基因组学的他克莫司治疗斯洛文尼亚肾移植患者的成本效益分析
Vasileios Fragoulakis,Margarita-Ioanna Koufaki,Gregor Mlinšek et al.
Vasileios Fragoulakis et al.
Tacrolimus (TAC) is one of the most widely prescribed maintenance immunosuppressant drugs in solid organ transplantation. Kidney transplantation is often the preferred treatment for patients with the kidney failure and is complemented with ...
Integrating epidemiology and genomics data to estimate the prevalence of acquired cysteine drug targets in the U.S. cancer patient population [0.03%]
整合流行病学和基因组学数据以估计在美国癌症患者人群中获得的胱氨酸药物靶点的流行率
Adith S Arun,David Liarakos,Gaurav Mendiratta et al.
Adith S Arun et al.
Reliable estimates for the number of cancer patients with a specific mutation can help quantify the size of the population that could potentially benefit from a targeted therapy. We adapt our previously developed approach for estimating gen...
CYP3A5 and POR gene polymorphisms as predictors of infection and graft rejection in post-liver transplant patients treated with tacrolimus - a cohort study [0.03%]
CYP3A5和POR基因多态性作为预测接受他克莫司治疗的肝移植患者感染和移植物排斥的指标-队列研究
Graziella D&#x; Agostino Ribeiro Naldi,Ariane Boccoli Minari,Thales D M Pereira et al.
Graziella D&#x; Agostino Ribeiro Naldi et al.
Liver transplantation is the only curative option for patients with advanced stages of liver disease, with tacrolimus used as the immunosuppressive drug of choice. Genetic variability can interfere with drug response, potentially leading to...
Genetic markers of early response to lurasidone in acute schizophrenia [0.03%]
急性精神分裂症患者对鲁拉西酮早期反应的遗传标记物
Akane Yoshikawa,Jiang Li,Ney Alliey-Rodriguez et al.
Akane Yoshikawa et al.
Prediction of treatment response by genetic biomarkers has potential for clinical use and contributes to the understanding of pathophysiology and drug mechanism of action. The purpose of this study is to detect genetic biomarkers possibly a...
Randomized Controlled Trial
The pharmacogenomics journal. 2025 Feb 20;25(2):3. DOI:10.1038/s41397-024-00360-z 2025
Systematic identification of cancer pathways and potential drugs for intervention through multi-omics analysis [0.03%]
通过多组学分析系统识别癌症通路及潜在的干预药物
Tuan Xu,Deborah K Ngan,Wei Zheng et al.
Tuan Xu et al.
The pathogenesis of cancer is complicated, and different types of cancer often exhibit different gene mutations resulting in different omics profiles. The purpose of this study was to systematically identify cancer-specific biological pathw...
The association between the number of HLA risk alleles and drug allergy and its implications for HLA screening - a case-control study [0.03%]
HLA风险等位基因的数量与药物过敏的关联及其对HLA筛查的影响-一项病例对照研究
Lisanne E N Manson,Jacqueline D H Anholts,Jos J M Drabbels et al.
Lisanne E N Manson et al.
Patients carrying specific HLA risk alleles are at higher risk for developing drug hypersensitivity reactions, yet pre-therapeutic screening is uncommon. We examined whether patients with a history of drug allergies have more HLA risk allel...
Genetic association analysis and frequency of NUDT15*3 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease in a large Dutch cohort [0.03%]
荷兰大样本炎症性肠病患者硫嘌呤诱导的骨髓抑制的遗传关联分析及NUDT15*3等位基因频率研究
Maarten J Deenen,Anouk J van Noordenburg,Joëlle Bouwens-Bijsterveld et al.
Maarten J Deenen et al.
Thiopurine drugs are cornerstone treatment for patients with inflammatory bowel disease (IBD). The most common adverse drug reaction is thiopurine-induced myelosuppression (TIM), that may partly be explained by the genetic polymorphism NUDT...
Polygenic score analyses on antidepressant response in late-life depression, results from the IRL-GRey study [0.03%]
基于IRL-GREY研究的老年抑郁患者抗抑郁药物反应的多基因得分分析
Samar S M Elsheikh,Victoria S Marshe,Xiaoyu Men et al.
Samar S M Elsheikh et al.
Late-life depression (LLD) is often accompanied by medical comorbidities such as psychiatric disorders and cardiovascular diseases, posing challenges to antidepressant treatment. Recent studies highlighted significant associations between t...