Influence of combined CYP2C19 and CYP2D6 phenotypes on adverse drug reactions in patients with major depressive disorder: a clinical cohort study [0.03%]
卡马西平和普瑞巴林联合治疗三叉神经痛的疗效及安全性：随机、双盲临床试验报告
Carolin Görnert,Maike Scherf-Clavel,Heike Weber et al.
Carolin Görnert et al.
Variants in cytochrome P450 enzymes are known risk factors for developing adverse drug reactions (ADR). Most antidepressants (AD) are simultaneously metabolized by major or minor pathway of CYP2C19 and CYP2D6, resulting in a complex interpl...
Economic effectiveness of pharmacogenomics-guided prescribing for psychiatric disorders: a systematic review and meta-analysis [0.03%]
精神类疾病用药指导的药物基因组学经济效益：系统评价和Meta分析
Ellen R Mason,Mohamed Y Ali,David S Gibson et al.
Ellen R Mason et al.
Pharmacogenomics (PGx)-guided prescribing is a promising approach to reduce variability in drug response, although its cost-effectiveness remains uncertain. We performed a systematic review and meta-analysis evaluating the cost-effectivenes...
Association of folylpolyglutamate synthase polymorphisms with methotrexate response and toxicity in rheumatoid arthritis: a meta-analysis [0.03%]
叶酸多聚谷氨酰胺合成酶基因多态性与类风湿关节炎甲氨蝶呤疗效和毒性的关联：一项meta分析研究
Young Ho Lee,Gwan Gyu Song
Young Ho Lee
This meta-analysis evaluated the association between FPGS gene polymorphisms (rs10106 (1994A > G) and rs1544105 (2572 C > T)) and methotrexate (MTX) efficacy and toxicity in rheumatoid arthritis (RA). Studies published up to October 2025 we...
A potential association of SLC2A9 variant rs7442295 with uric acid at baseline and in interaction with iloperidone [0.03%]
基线SLC2A9基因变异rs7442295与尿酸的潜在关联及其与伊洛平的交互作用
Sandra P Smieszek,Sean R Chadwick,Emily L Czeisler et al.
Sandra P Smieszek et al.
Circulating levels of uric acid are influenced by a complex mix of intrinsic and environmental factors, including genetics, diet, and drugs. We analyzed levels of uric acid in a recent phase 3 clinical trial of patients with bipolar mania t...
Tumour immune cell infiltration and response to FOLFOX or FOLFIRI chemotherapy in colorectal cancer [0.03%]
结直肠癌肿瘤免疫细胞浸润和FOLFOX或FOLFIRI化疗反应关系的研究
Jia Feng,Lei Zhang,Zhijun Liao et al.
Jia Feng et al.
Tumor immune cell infiltration plays an important role in determining treatment response and prognosis in colorectal cancer (CRC). This study aimed to investigate the association between tumor immune landscape and clinical outcomes in CRC p...
Computational variant predictors for pharmacogenomics: from evaluation of single alleles to assessment of adverse drug reactions to antidepressants [0.03%]
计算型药理基因组学变异预测器：从单一等位基因评估到抗抑郁剂不良反应评估
Jacek Hajto,Marcin Piechota,Ilse Krätschmer et al.
Jacek Hajto et al.
Currently, pharmacogenetics relies on partially annotated star alleles, leaving novel variants and complex haplotypes uninterpretable. Computational scoring frameworks could overcome these limitations. Here, we comprehensively evaluated the...
Ben L Kong,Bernard Esquivel,Mohamed Nagy et al.
Ben L Kong et al.
Sara L Rogers,Susanne B Haga,Karina Yonekawa-Blest et al.
Sara L Rogers et al.
Potential of pharmacogenetics in treatment of chronic inflammatory diseases - a danish report overview from 2000 - 2024 [0.03%]
药理遗传学在慢性炎症性疾病治疗中的潜力——一份丹麦2000-2024年的报告概述
Trine Andresen,José A G Agúndez,Hela Nazari et al.
Trine Andresen et al.
Given the substantial degree of inter-individual variability in treatment responses in patients with inflammatory bowel disease (IBD), treatment optimization is warranted. We provide an overview of pharmacogenetic variants that can affect t...
A functional ancestry-linked regulatory haplotype influences CYP2D6 expression [0.03%]
一个功能性的亲缘相关性调节单体型影响CYP2D6表达
Michael McCoy
Michael McCoy
Cytochrome P450 (CYP) enzymes metabolize 70-80% of therapeutic agents, yet regulatory variants affecting drug metabolism remain poorly characterized across populations. Although numerous studies have examined coding variants in pharmacogene...