The need of a multicomponent guiding approach to personalize clopidogrel treatment [0.03%]
个性化氯吡格雷治疗需要多组分指导方法
Conti Valeria,Sellitto Carmine,Manzo Valentina et al.
Conti Valeria et al.
Patients bearing polymorphisms termed CYP2C19 loss of function (LoF) alleles and ABCB1-C3435T may do not properly respond to standard dosage of clopidogrel and have an increased risk of thrombosis. Moreover, co-administration of proton pump...
Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population [0.03%]
尼加拉瓜混合血统人群中细胞色素P1A2、P2C9、P2C19、P2D6和P3A4代谢表型与基因型之间的关系
Fernando de Andrés,Catalina Altamirano-Tinoco,Ronald Ramírez-Roa et al.
Fernando de Andrés et al.
Interethnic variability in the drug-metabolizing capacity of CYP450 enzymes may lead to discrepancies in the relationship between genotypes and phenotypes worldwide. The present study was aimed to analyze for the first time whether there is...
Characterization of four BCHE mutations associated with prolonged effect of suxamethonium [0.03%]
四个与硫咗啡林作用时间延长有关的BCHE突变体的特性分析
Xavier Brazzolotto,Sébastien Courcelle,Christophe Sauvanet et al.
Xavier Brazzolotto et al.
Butyrylcholinesterase (BChE) deficiency is characterized by prolonged apnea after the use of muscle relaxants (suxamethonium or mivacurium) in patients who have mutations in the BCHE gene. Here, we report the characterization of four BCHE m...
Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy [0.03%]
接受铂类化疗的睾丸癌患者心血管疾病的全基因组关联研究
Lars C Steggink,Hink Boer,Coby Meijer et al.
Lars C Steggink et al.
Genetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-treated testicular cancer (TC) patients compared to the general population. Involved single nucleotide polymorphisms (SNPs) might differ from k...
Correction: ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy [0.03%]
校正：ERCC2基因单核苷酸多态性作为确定的基于顺铂的放射化学治疗后局部晚期头颈癌的预后因素
Maja Guberina,Ali Sak,Christoph Pöttgen et al.
Maja Guberina et al.
Published Erratum
The pharmacogenomics journal. 2021 Apr;21(2):273. DOI:10.1038/s41397-020-00193-6 2021
HLA-B*39:01:01 is a novel risk factor for antithyroid drug-induced agranulocytosis in Japanese population [0.03%]
HLA-B*39:01:01是日本人群抗甲状腺药物所致粒细胞缺乏症的新危险因素
Saya Nakakura,Kazuyoshi Hosomichi,Shinya Uchino et al.
Saya Nakakura et al.
Antithyroid drug (ATD) is a mainstay of Graves' disease (GD). About 0.1-0.5% of patients with GD treated with ATD exhibit ATD-induced agranulocytosis, which is characterized by severe reduction of circulating neutrophils. Immune-mediated re...
Validated prognostic significance of YB-1 genetic variation in metastatic prostate cancer [0.03%]
YB-1基因变异在转移性前列腺癌中的预后意义验证研究
Masaki Shiota,Shintaro Narita,Tomonori Habuchi et al.
Masaki Shiota et al.
Genetic polymorphism in YB-1 was previously shown to be associated with the prognosis of advanced prostate cancer patients treated with primary androgen-deprivation therapy. However, the significance of this polymorphism remains invalidated...
Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review [0.03%]
与上消化道出血相关的遗传多态性：系统综述
Marcela Forgerini,Rosa Camila Lucchetta,Gustavo Urbano et al.
Marcela Forgerini et al.
Non-variceal upper gastrointestinal bleeding (non-variceal UGIB) is a frequent and severe adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal UGIB has been suggested. A systematic review was conducte...
Investigating an in silico approach for prioritizing antidepressant drug prescription based on drug-induced expression profiles and predicted gene expression [0.03%]
基于药物诱导的表达谱和预测基因表达的计算方法优先考虑抗抑郁药处方的研究
Muhammad Shoaib,Edoardo Giacopuzzi,Oliver Pain et al.
Muhammad Shoaib et al.
In clinical practice, an antidepressant prescription is a trial and error approach, which is time consuming and discomforting for patients. This study investigated an in silico approach for ranking antidepressants based on their hypothetica...
Correction: Influence of CYP3A polymorphisms on tacrolimus pharmacokinetics in kidney transplant recipients [0.03%]
校正：CYP3A基因多态性对肾移植受者他克莫司药代动力学的影响
Ibtissem Hannachi,Zohra Chadli,Emna Kerkeni et al.
Ibtissem Hannachi et al.
Published Erratum
The pharmacogenomics journal. 2021 Feb;21(1):107. DOI:10.1038/s41397-020-00184-7 2021