Evaluation of experiential teaching approaches to enhance pharmacy students' confidence and knowledge in pharmacogenomics [0.03%]
体验式教学在提升药学学生精准用药知识及自信度的效果评估研究
Ruby Soueid,Toni J F Michael,Pete Yeap et al.
Ruby Soueid et al.
Pharmacogenomic services are commonly pharmacist-led, yet pharmacists report poor knowledge and confidence in application. This study evaluated an experiential teaching approach to enhance students' confidence and knowledge in pharmacogenom...
Genome-wide screening of pharmacogenomic biomarkers in jordanian patients with genetic disorders [0.03%]
约旦遗传病患者药物基因组生物标志物的全基因组筛选
Yazun Jarrar,Nancy Hakooz,Dina Abu Hashem et al.
Yazun Jarrar et al.
Introduction: Pharmacogenomics (PGx) testing aims to identify the most appropriate drug and dose for individual patients based on their genetic profiles. In Jordan, patients with genetic disorders often use multiple medic...
Wrenda Teeple,Jeffrey A Shaman,Tootie Tatum et al.
Wrenda Teeple et al.
Serine-arginine protein kinase 1 (SRPK1) is under-expressed in mucinous colorectal cancer, and may mediate resistance to oxaliplatin [0.03%]
粘液性结直肠癌中丝氨酸/精氨?蛋白激酶1低表达并可能介导奥沙利铂耐药性
William P Duggan,Mohammedreza Azimi,Lyndsey Flanagan et al.
William P Duggan et al.
5-15% of all colorectal cancers (CRCs) are mucinous. Mucinous CRCs are associated with an inhibited response to standard adjuvant and neoadjuvant therapies. Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme, which modulates the activity...
An innovative model for pharmacogenomics critical results identification and intervention [0.03%]
一种用于药物基因组学关键结果识别和干预的创新型模型
Ryley Uber,Vanessa A Hayduk,Alison Flango et al.
Ryley Uber et al.
Pharmacogenomics (PGx) test results are returned variably across healthcare settings, which can lead to challenges particularly when results require immediate intervention to avoid adverse consequences. While several return of result models...
Antidepressant drug switching in the Swiss population with a focus on Escitalopram and drugs with pharmacogenetic dosing guidelines: a drug utilization study using claims data [0.03%]
基于理赔数据的瑞士抗抑郁药换用现象分析及药物基因组剂量指导意义——以艾司西酞普兰为例
M M Roth,C R Meier,C A Huber et al.
M M Roth et al.
Depression affects around 10% of the Swiss population. While SSRIs are commonly prescribed, only 30-40% of patients achieve remission. Pharmacogenetic (PGx) factors may explain part of this high rate of SSRI treatment failure. This study ex...
Benchmarking large language models for replication of guideline-based PGx recommendations [0.03%]
基于指南的药物基因组学建议的大规模语言模型基准测试复制
Mike Zack,Ioan Slobodchikov,Danil Stupichev et al.
Mike Zack et al.
We evaluated the ability of large language models (LLMs) to generate clinically accurate pharmacogenomic (PGx) recommendations aligned with CPIC guidelines. Using a benchmark of 599 curated gene-drug-phenotype scenarios, we compared five le...
Impact of low BMI and ABCC2 genotype on the clinical response of sequential anthracycline-taxane chemotherapy receiving breast cancer patients: a hospital-based study [0.03%]
低体质指数和ABCC2基因型对序贯蒽环类-紫衫类化疗乳腺癌患者的临床疗效影响：一项基于医院的研究
Tanuma Mistry,Sanghamitra Sengupta,R Suresh Kumar et al.
Tanuma Mistry et al.
This study investigates combine effect of low BMI and possible pharmacogenetic influence of ABC gene polymorphisms in treatment responses of BC patients. BMI was analysed prior to commencement of chemotherapy. Clinical response was evaluate...
Correction: Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity [0.03%]
纠正：将罕见遗传变异纳入DPYD药物基因组学检测可能有助于预防氟尿嘧啶引起的毒性
Romain Larrue,Sandy Fellah,Benjamin Hennart et al.
Romain Larrue et al.
Published Erratum
The pharmacogenomics journal. 2025 Jul 15;25(4):21. DOI:10.1038/s41397-025-00381-2 2025
Pharmacogenomic-guided opioid therapy for pain: a systematic review and meta-analysis of randomised controlled trials [0.03%]
一项系统评价和随机对照试验的meta分析：以药理基因组学指导疼痛的阿片类药物治疗
S Jethwa,M Ball,K Langlands
S Jethwa
Optimising opioid therapy is challenging due to variable patient responses linked to genetic variation. Pharmacogenomic-guided prescribing holds promise for personalisation, but its clinical effectiveness requires evaluation. We performed a...