Ischemic stroke and myocardial ischemia in clopidogrel users and the association with CYP2C19 loss-of-function homozygocity: a real-world study [0.03%]
氯吡格雷使用者的缺血性卒中和心肌缺血与CYP2C19功能丧失型纯合子的相关性：一项真实世界研究
Naomi Gronich,Idit Lavi,Flavio Lejbkowicz et al.
Naomi Gronich et al.
Reduced clopidogrel effectiveness in preventing recurrent myocardial ischemia following percutaneous coronary intervention has been demonstrated in CYP2C19 loss-of-function carriers. Less is known about the effect of CYP2C19 genotype on the...
A systematic review and meta-analysis of genotype-based and individualized data analysis of SLCO1B1 gene and statin-induced myopathy [0.03%]
基于基因型和个体化数据的SLCO1B1基因与他汀类药物诱导的肌病的系统评价和meta分析
Saowalak Turongkaravee,Jiraphun Jittikoon,Thitiya Lukkunaprasit et al.
Saowalak Turongkaravee et al.
This meta-analysis was conducted to determine the genotypic effects of rs4149056 and rs2306283 polymorphism in SLCO1B1 gene on myopathy in patients with statin. Studies were searched using multiple databases and selected following inclusion...
Effects of CYP2C19 genetic polymorphism on the steady-state concentration of citalopram in patients with major depressive disorder [0.03%]
CYP2C19基因多态性对抑郁症患者稳态浓度的影响
M S Zastrozhin,V Yu Skryabin,A E Petukhov et al.
M S Zastrozhin et al.
Citalopram is commonly prescribed to patients suffering from major depressive disorder. Some of them do not respond adequately to therapy with citalopram, while many of them experience type A adverse drug reactions. Current research reveale...
The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens [0.03%]
氟尿嘧啶类药物治疗的消化系统恶性肿瘤患者中TYMS基因2R/2R纯合子型分布及临床意义
Moh&#x;d Khushman,Girijesh Kumar Patel,Anu Singh Maharjan et al.
Moh&#x;d Khushman et al.
Introduction: The prevalence of 2R/2R TYMS genotype is variable but estimated to be around 20-30% in Caucasians. The clinical relevance of TYMS 2R/2R genotype in predicting severe fluoropyrimidine-related adverse events (...
Pharmacogenetics of ATP binding cassette transporter MDR1(1236C>T) gene polymorphism with glioma patients receiving Temozolomide-based chemoradiation therapy in Indian population [0.03%]
基于印度人群胶质瘤患者接受卡莫司汀联合化疗放射治疗的ATP结合盒转运蛋白多药耐药基因多态性的药效遗传学研究
Murali Munisamy,Srinivasan Munisamy,Julka Pramod Kumar et al.
Murali Munisamy et al.
Temozolomide (TMZ), an alkylating agent with a broad-spectrum antitumor activity, ability to cross blood-brain barrier (BBB), shown to be effective against malignant glioma. This study aims to investigate the effect of 1236C>T (rs1128503) s...
Rates of genetic testing in patients prescribed drugs with pharmacogenomic information in FDA-approved labeling [0.03%]
FDA批准的具有药理基因组信息的药物处方患者的基因检测率
John Young,Kaustuv Bhattacharya,Sujith Ramachandran et al.
John Young et al.
This study examined rates of genetic testing in two cohorts of publicly insured individuals who have newly prescribed medication with FDA pharmacogenomic labeling guidance. Genetic testing was rare (4.4% and 10.5% in Medicaid and Medicare c...
Identification of a sex-stratified genetic algorithm for opioid addiction risk [0.03%]
识别性别分层的阿片类药物成瘾风险遗传算法
David Bright,Anna Langerveld,Susan DeVuyst-Miller et al.
David Bright et al.
The opioid epidemic has had a devastating impact on our country, with wide-ranging effects on healthcare, corrections, employment, and social systems. Programs have been put in place for monitoring prescriptions, initiating and expanding me...
Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs [0.03%]
药物基因组学与COVID-19：人类基因组与老药再利用的临床相互作用含义
Osama A Badary
Osama A Badary
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global pandemic. Many drugs without established efficacy are being used to treat COVID-19 patients either as an offlabel/compassionate use or as a clinical tri...
Clinical significance of enterocyte-specific gene polymorphisms as candidate markers of oxaliplatin-based treatment for metastatic colorectal cancer [0.03%]
以结肠直肠癌转移oxaliplatin为基础的治疗候选标志物的上皮细胞特异性基因多态性的临床意义
Mitsukuni Suenaga,Marta Schirripa,Shu Cao et al.
Mitsukuni Suenaga et al.
Colorectal cancer (CRC) can be classified into subtypes based on gene expression signatures. Patients with stage III enterocyte subtype of the CRC Assigner classifier have been shown to benefit from oxaliplatin adjuvant therapy. Here, we in...
Cyrius: accurate CYP2D6 genotyping using whole-genome sequencing data [0.03%]
Cyrius：利用全基因组测序数据进行准确的CYP2D6基因分型
Xiao Chen,Fei Shen,Nina Gonzaludo et al.
Xiao Chen et al.
Responsible for the metabolism of ~21% of clinically used drugs, CYP2D6 is a critical component of personalized medicine initiatives. Genotyping CYP2D6 is challenging due to sequence similarity with its pseudogene paralog CYP2D7 and a high ...