Increased expression of IFI16 predicts adverse prognosis in multiple myeloma [0.03%]
IFI16高表达预示多发性骨髓瘤的不良预后
Wenhui Huang,Tingting Qian,Zeyong Huang et al.
Wenhui Huang et al.
Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells and does not have sufficient prognostic indicators. Interferon gamma inducible protein 16 (IFI16) plays a crucial role in B-cell differentiation. Several studie...
Single nucleotide polymorphisms to predict taxanes toxicities and effectiveness in cancer patients [0.03%]
用于预测癌症患者紫杉烷类药物毒副作用的单核苷酸多态性标志物研究进展
Sara Demurtas,Nicla La Verde,Selene Rota et al.
Sara Demurtas et al.
Taxanes are used in the treatment of several solid tumours. Adverse events (AEs) might be influenced by single nucleotide polymorphisms (SNPs) in genes encoding proteins responsible for pharmacokinetic and pharmacodynamic. In this prospecti...
Observational Study
The pharmacogenomics journal. 2021 Aug;21(4):491-497. DOI:10.1038/s41397-021-00227-7 2021
Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women [0.03%]
他汀类药物使用后的癌症遗传meta分析发现了新的关联并确定了女性中的人类白细胞抗原（HLA）的作用
Maxine Sun,Audrey Lemaçon,Marc-André Legault et al.
Maxine Sun et al.
We sought to perform a genomic evaluation of the risk of incident cancer in statin users, free of cancer at study entry. Patients who previously participated in two phase IV trials (TNT and IDEAL) with genetic data were used (npooled = 11,1...
Development of a population pharmacokinetic model and Bayesian estimators for isoniazid in Tunisian tuberculosis patients [0.03%]
在突尼斯结核病患者中异烟肼的群体药代动力学模型及其贝叶斯估计方法的建立
Mohammed Alshaikheid,Nadia Ben Fredj,Ibtissem Hannachi et al.
Mohammed Alshaikheid et al.
This study aimed to develop a population pharmacokinetic model using full pharmacokinetic (PK) profiles of isoniazid (INH) taking into account demographic and genetic covariates and to develop Bayesian estimators for predicting INH area und...
Antihypertensive treatment guided by genetics: PEARL-HT, the randomized proof-of-concept trial comparing rostafuroxin with losartan [0.03%]
基于遗传的降压治疗：PEARL-HT试验，一项将rostafuroxin与losartan对比的概念验证性随机试验
Lorena Citterio,Giuseppe Bianchi,Giuseppe A Scioli et al.
Lorena Citterio et al.
We compared a standard antihypertensive losartan treatment with a pharmacogenomics-guided rostafuroxin treatment in never-treated Caucasian and Chinese patients with primary hypertension. Rostafuroxin is a digitoxigenin derivative that sele...
Randomized Controlled Trial
The pharmacogenomics journal. 2021 Jun;21(3):346-358. DOI:10.1038/s41397-021-00214-y 2021
The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA [0.03%]
FLNA和FLNB基因多态性通过差异表达的mRNA与高血压及卒中易感性的关联研究
Chunlan Liu,Wuzhuang Tang,Hailong Zhao et al.
Chunlan Liu et al.
Background: Filamin A and filamin B were involved in vascular development and remodeling. Herein, it is important to explore the associations of FLNA and FLNB variants with hypertension and stroke. ...
Transcriptional analysis of sodium valproate in a serotonergic cell line reveals gene regulation through both HDAC inhibition-dependent and independent mechanisms [0.03%]
丙戊酸通过组蛋白去乙酰化酶抑制依赖性和非依赖性机制调节五羟色胺能细胞系中的基因表达的转录分析
Priyanka Sinha,Simone L Cree,Allison L Miller et al.
Priyanka Sinha et al.
Sodium valproate (VPA) is a histone deacetylase (HDAC) inhibitor, widely prescribed in the treatment of bipolar disorder, and yet the precise modes of therapeutic action for this drug are not fully understood. After exposure of the rat sero...
Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir [0.03%]
探讨相关药物基因组变异对口服多西他赛联合利托那韦药代动力学和药效学的影响
Maarten van Eijk,Dick Pluim,Thomas P C Dorlo et al.
Maarten van Eijk et al.
The anticancer drug docetaxel exhibits large interpatient pharmacokinetic and pharmacodynamic variability. In this study, we aimed to assess the functional significance of 14 polymorphisms in the CYP3A, CYP1B1, ABCB1, ABCC2, and SLCO1B3 gen...
The association between missense polymorphisms in SRD5A2 and HSD3B1 and treatment failure with abiraterone for castration-resistant prostate cancer [0.03%]
SRD5A2和HSD3B1的错义多态性与去势抵抗性前列腺癌患者接受阿比特龙治疗失败的相关性分析
Masaki Shiota,Shusuke Akamatsu,Shintaro Narita et al.
Masaki Shiota et al.
Missense polymorphism in HSD3B1, encoding 3β-hydroxysteroid dehydrogenase-1, was associated with outcome after abiraterone treatment. Other androgen-metabolizing enzymes may be involved in therapeutic effect in abiraterone. In this study, ...
Functional CYP3A variants affecting tacrolimus trough blood concentrations in Chinese renal transplant recipients [0.03%]
功能型CYP3A变异影响中国肾移植受者他克莫司稳态血药浓度
Dina Chen,Huijie Lu,Weiguo Sui et al.
Dina Chen et al.
The aim of this study was to identify novel genetic variants affecting tacrolimus trough blood concentrations. We analyzed the association between 58 single nucleotide polymorphisms (SNPs) across the CYP3A gene cluster and the log-transform...