ABCC4 single-nucleotide polymorphisms as markers of tenofovir disoproxil fumarate-induced kidney impairment [0.03%]
ABCC4单核苷酸多态性作为替诺福韦酯致肾损害标志物的研究
Stefania Cheli,Sara Baldelli,Annalisa De Silvestri et al.
Stefania Cheli et al.
Recently, the use of antiretroviral drug tenofovir disoproxil fumarate (TDF) is increased, thanks to the new co-formulation with doravirine, the availability of booster-free regimens, and its advantageous lipid-lowering effect. The aim of o...
Alaa Yehya,Zaid Altaany
Alaa Yehya
The aim of this study was to perform a systematic overview of the pharmacogenetic studies conducted in Jordan. A structured search of Medline was conducted for articles over the last decade (January 2010-July 2020). Studies were classified ...
Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model [0.03%]
基于HLA-B*15:02基因分型的抗癫痫药物致剥脱性皮炎的成本效益分析：建模研究
Rika Yuliwulandari,Jae Gook Shin,Erna Kristin et al.
Rika Yuliwulandari et al.
Carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are strongly associated with the HLA-B*15:02 allele. Screening HLA-B*15:02 before CBZ administration might prevent CBZ-induced SJS/TEN by enabling...
Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study [0.03%]
选择性五羟色胺再摄取抑制剂治疗中与心血管元代谢异常相关的基因变异：一项全基因组关联研究
Katrine K Fjukstad,Lavinia Athanasiu,Shahram Bahrami et al.
Katrine K Fjukstad et al.
Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia and bipolar disorder. Previous studies have shown associations between SSRI treatment and cardiometabolic alterations. The aim of the present...
CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice [0.03%]
临床实践中CYP2D6基因型与可待因镇痛效果减弱的关系
Daniel Carranza-Leon,Alyson L Dickson,Andrea Gaedigk et al.
Daniel Carranza-Leon et al.
Cytochrome P450 2D6 (CYP2D6) O-demethylates codeine to the active drug, morphine. However, the utility of testing for CYP2D6 metabolizer status in patients receiving codeine in real-world clinical practice is poorly defined. Using data from...
Clinical and genetic influencing factors on clozapine pharmacokinetics in Tunisian schizophrenic patients [0.03%]
影响突尼斯精神分裂症患者氯氮平药代动力学的临床及遗传因素
Helmi Ammar,Zohra Chadli,Ahmed Mhalla et al.
Helmi Ammar et al.
Clozapine (Clz) is an atypical antipsychotic, which its pharmacokinetics can be influenced by several factors. The CYP1A2 and CYP2C19, major enzymes implicated in Clz metabolism, present an interethnic variation on their activity caused by ...
Serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic Malay patients with first episode of major depressive disorder [0.03%]
五羟色胺受体基因多态性与马来人群首发抑郁症选择性五羟色胺再摄取抑制剂治疗效应的关系研究
Ibrahim Mohammed Badamasi,Munn Sann Lye,Normala Ibrahim et al.
Ibrahim Mohammed Badamasi et al.
The polymorphisms of the 5HTR1A and 5HTR2A receptor genes (rs6295C/G and rs6311G/A) have been evaluated for association with SSRI treatment outcome in various populations with different results. The present study was carried out to determin...
Pharmacogenetic-guided glimepiride therapy in type-2 diabetes mellitus: a cost-effectiveness study [0.03%]
基于药物基因组学指导的格列美脲治疗2型糖尿病的成本效益研究
Cécile Fokoun,Hassan Serrier,Hugo Rabier et al.
Cécile Fokoun et al.
The demonstration of the link between certain genetic variations and drug response has allowed the emergence of pharmacogenetics, which offers many opportunities to improve patient care. Type-2 diabetes mellitus is a disease for which sever...
A survey of cancer genome signatures identifies genes connected to distinct chromosomal instability phenotypes [0.03%]
一项关于癌症基因组特征的调查发现了与不同的染色体不稳定性表型相关的基因
Manar S Shafat,Eamaan S Rufaie,Johnathan Watkins
Manar S Shafat
Certain breast and ovarian cancers are characterised by high levels of chromosomal instability. We established a suite of eleven SNP array-based signatures of various forms of chromosomal instability. To understand what biological mechanism...
Mucinous and non-mucinous colorectal cancers show differential expression of chemotherapy metabolism and resistance genes [0.03%]
黏液性癌和非粘液性结直肠癌的化疗代谢及耐药基因的表达差异分析
E O&#x;Connell,I S Reynolds,M Salvucci et al.
E O&#x;Connell et al.
Previous research has identified differences in mutation frequency in genes implicated in chemotherapy resistance between mucinous and non-mucinous colorectal cancers (CRC). We hypothesized that outcomes in mucinous and non-mucinous CRC may...