Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis [0.03%]
泰国癫痫患者芳香族抗癫痫药物引起的皮肤不良反应谱系及人类白细胞抗原基因型.meta分析
Chonlaphat Sukasem,Suthida Sririttha,Chonlawat Chaichan et al.
Chonlaphat Sukasem et al.
Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) add up to the limited use of the AEDs in the treatment and prevention of seizures. Human leukocyte antigen-B (HLA-B) alleles have been linked to AEDs-induc...
New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin [0.03%]
在急性冠脉综合征患者中发现与氯吡格雷和阿司匹林联合治疗的心血管不良事件相关的新型基因变异
Xiaomin Liu,Hanshi Xu,Huaiqian Xu et al.
Xiaomin Liu et al.
Although a few studies have reported the effects of several polymorphisms on major adverse cardiovascular events (MACE) in patients with acute coronary syndromes (ACS) and those undergoing percutaneous coronary intervention (PCI), these gen...
Side effect prediction based on drug-induced gene expression profiles and random forest with iterative feature selection [0.03%]
基于药物引起的基因表达谱和具有迭代特征选择的随机森林的副作用预测方法
Arzu Cakir,Melisa Tuncer,Hilal Taymaz-Nikerel et al.
Arzu Cakir et al.
One in every ten drug candidates fail in clinical trials mainly due to efficacy and safety related issues, despite in-depth preclinical testing. Even some of the approved drugs such as chemotherapeutics are notorious for their side effects ...
Pharmacoepigenomics circuits induced by a novel retinoid-polyamine conjugate in human immortalized keratinocytes [0.03%]
一种新型视黄醇-聚胺结合物在人类角质形成细胞永生化细胞系中诱导的药理表观遗传通路
Katerina Grafanaki,Ilias Skeparnias,Christos K Kontos et al.
Katerina Grafanaki et al.
Retinoids are widely used in diseases spanning from dermatological lesions to cancer, but exhibit severe adverse effects. A novel all-trans-Retinoic Acid (atRA)-spermine conjugate (termed RASP) has shown previously optimal in vitro and in v...
The impact of pharmacogenetic testing in patients exposed to polypharmacy: a scoping review [0.03%]
药物基因组检测在多药联合治疗中的影响：系统综述
Erika L Meaddough,Sara M Sarasua,Tracy K Fasolino et al.
Erika L Meaddough et al.
Polypharmacy poses a significant risk for adverse reactions. While there are clinical decision support tools to assist clinicians in medication management, pharmacogenetic testing to identify potential drug-gene or drug-drug-gene interactio...
Conference report: inaugural Pharmacogenomics Access & Reimbursement Symposium [0.03%]
会议报道：首届药物基因组学应用及偿还研讨会
Sara L Rogers,George P Patrinos,Christina Mitropoulou et al.
Sara L Rogers et al.
The Pharmacogenomics Access & Reimbursement Symposium, a landmark event presented by the Golden Helix Foundation and the Pharmacogenomics Access & Reimbursement Coalition (PARC), was a one-day interactive meeting comprised of plenary keynot...
Genetic-guided pharmacotherapy for venous thromboembolism: a systematic and critical review of economic evaluations [0.03%]
基于遗传学的血栓指导给药治疗经济型评价系统回顾与分析
Ka Keat Lim,Rositsa Koleva-Kolarova,Philip Chowienczyk et al.
Ka Keat Lim et al.
Despite the known contributions of genes, genetic-guided pharmacotherapy has not been routinely implemented for venous thromboembolism (VTE). To examine evidence on cost-effectiveness of genetic-guided pharmacotherapy for VTE, we searched s...
Determining the potential clinical value of panel-based pharmacogenetic testing in patients with chronic pain or gastroesophageal reflux disease [0.03%]
检测慢性疼痛或胃食管反流病患者基于 panels 的药物基因组学检测的潜在临床价值
Amanda L Elchynski,Emily J Cicali,Maria C Ferrer Del Busto et al.
Amanda L Elchynski et al.
We aimed to determine the potential value of panel-based pharmacogenetic (PGx) testing in patients with chronic pain or gastroesophageal reflux disease (GERD) who underwent single-gene PGx testing to guide opioid or proton pump inhibitor (P...
Gene expression signatures predict response to therapy with growth hormone [0.03%]
基因表达标志物可预测生长激素的治疗反应
Adam Stevens,Philip Murray,Chiara De Leonibus et al.
Adam Stevens et al.
Recombinant human growth hormone (r-hGH) is used as a therapeutic agent for disorders of growth including growth hormone deficiency (GHD) and Turner syndrome (TS). Treatment is costly and current methods to model response are inexact. GHD (...
Overexpression of P-glycoprotein and MRP-1 are pharmacogenomic biomarkers to determine steroid resistant phenotype in childhood idiopathic nephrotic syndrome [0.03%]
P-糖蛋白和MRP-1的过表达可作为儿童原发性肾病综合征类固醇抵抗表型的药理基因组生物标志物
Narayan Prasad,Harshit Singh,Akhilesh Jaiswal et al.
Narayan Prasad et al.
Steroid remains the keystone therapy for Idiopathic Nephrotic Syndrome (NS). Besides genetic factors and histological changes, pharmacogenomic factors also affect the steroid response. The upregulation of P-glycoprotein (P-gp) and Multidrug...