Genetic polymorphisms in ADRB2 and ADRB1 are associated with differential survival in heart failure patients taking β-blockers [0.03%]
心力衰竭患者ADRB2和ADRB1基因多态性与接受β受体阻滞剂的不同生存率相关
Leonardo A Guerra,Christelle Lteif,Meghan J Arwood et al.
Leonardo A Guerra et al.
Single nucleotide polymorphisms (SNPs) have been associated with differential beta-blocker (BB) effects on heart rate, blood pressure, and left ventricular ejection fraction in various patient populations. This study aimed to determine if S...
A NOS1AP gene variant is associated with a paradoxical increase of the QT-interval shortening effect of digoxin [0.03%]
NOS1AP基因变异与地高辛引起QT间期缩短的悖论性增加有关
Negin Soroush,Albert-Jan Aarnoudse,Maryam Kavousi et al.
Negin Soroush et al.
Digoxin is characterized by a small therapeutic window and a QT-interval shortening effect. Moreover, it has been shown that the genetic variants of the nitric oxide synthase-1 adaptor protein (NOS1AP) gene are associated with QT-interval p...
Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals [0.03%]
巴西HIV阳性患者抗逆转录病毒治疗的病毒学反应与CYP酶多态性、NR1I2和NR1I3的相关性研究
Camila de Almeida Velozo,Tailah Bernardo de Almeida,Marcelo Costa Velho Mendes de Azevedo et al.
Camila de Almeida Velozo et al.
Virologic failure of antiretroviral therapy (ART) may be explained by single nucleotide polymorphisms (SNPs) in drug absorption and metabolism genes. Here, we characterized the associations between polymorphisms in cytochrome P450 enzymes' ...
Impact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests [0.03%]
在临床尿药检数据库中考察CYP2C19、CYP2D6和CYP3A4基因多态性对氧可酮及其代谢产物的影响
Guang-Dan Zhu,Penn Whitley,Leah LaRue et al.
Guang-Dan Zhu et al.
Urine drug testing (UDT) is a tool for monitoring drug use, including oxycodone. While variation in cytochrome P450 (CYP) genes is known to alter oxycodone metabolism, its impact on UDT results of oxycodone and its metabolites has not been ...
Genetic factors contributing to late adverse musculoskeletal effects in childhood acute lymphoblastic leukemia survivors [0.03%]
基因因素导致儿童急性淋巴细胞白血病幸存者晚期不良肌肉骨骼影响不容忽视
A Shalmiev,G Nadeau,M Aaron et al.
A Shalmiev et al.
Background: A substantial number of survivors of childhood acute lymphoblastic leukemia (ALL) suffer from treatment-related late adverse effects. While multiple studies have identified the effects of chemotherapeutics and...
Epigenetic moderators of naltrexone efficacy in reducing heavy drinking in Alcohol Use Disorder: a randomized trial [0.03%]
阿片受体拮抗剂治疗酒精使用障碍的表观遗传调节因素：一项随机试验
Joseph P Schacht,Michaela Hoffman,Brian H Chen et al.
Joseph P Schacht et al.
Polymorphisms in genes associated with opioid signaling and dopamine reuptake and inactivation may moderate naltrexone efficacy in Alcohol Use Disorder (AUD), but the effects of epigenetic modification of these genes on naltrexone response ...
Randomized Controlled Trial
The pharmacogenomics journal. 2022 Feb;22(1):1-8. DOI:10.1038/s41397-021-00250-8 2022
Appraisal and development of evidence-based clinical decision support to enable perioperative pharmacogenomic application [0.03%]
基于证据的临床决策支持体系的评估与开发以推动药理基因组学在围手术期的应用
Brittany A Borden,Ellie H Jhun,Keith Danahey et al.
Brittany A Borden et al.
Variable responses to medications complicates perioperative care. As a potential solution, we evaluated and synthesized pharmacogenomic evidence that may inform anesthesia and pain prescribing to identify clinically actionable drug/gene pai...
G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19 [0.03%]
非洲撒哈拉以南地区G6PD分布及使用氯喹/羟氯喹衍生疗法治疗COVID-19的潜在风险评估
Jorge E B da Rocha,Houcemeddine Othman,Caroline T Tiemessen et al.
Jorge E B da Rocha et al.
Chloroquine/hydroxychloroquine have been proposed as potential treatments for COVID-19. These drugs have warning labels for use in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Analysis of whole genome sequence data ...
AHR-dependent genes and response to MTX therapy in rheumatoid arthritis patients [0.03%]
RAR的依赖基因及MTX治疗风湿性关节炎患者的反应
Anna Wajda,Ewa Walczuk,Barbara Stypińska et al.
Anna Wajda et al.
Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis. Nevertheless, MTX resistance is quite a common issue in clinical practice. There are some premises that aryl hydrocarbon receptor (AhR) gene battery may take part in MTX...
Economic evaluation in psychiatric pharmacogenomics: a systematic review [0.03%]
精神病药理基因组学中的经济评估：系统性综述
Kariofyllis Karamperis,Maria Koromina,Panagiotis Papantoniou et al.
Kariofyllis Karamperis et al.
Nowadays, many relevant drug-gene associations have been discovered, but pharmacogenomics (PGx)-guided treatment needs to be cost-effective as well as clinically beneficial to be incorporated into standard health care. To address current ch...