Effect of CYP2C19 polymorphisms on antidepressant prescription patterns and treatment emergent mania in bipolar disorder [0.03%]
CYP2C19基因多态性对双相情感障碍中抗抑郁药物处方模式及治疗所致躁狂的影响
Erik Joas,Lina Jonsson,Alexander Viktorin et al.
Erik Joas et al.
Antidepressant medication is used extensively to treat bipolar depression despite uncertain efficacy. The cytochrome P450 (CYP) 2C19 enzyme metabolize several antidepressants, and polymorphisms in the corresponding gene CYP2C19 influence pl...
Clinical utility of pharmacogenetics in a psychiatric and primary care population [0.03%]
精神病和普通门诊患者药物基因组学的临床应用价值研究
Krista N Bohlen,Julie M Kittelsrud,Morgan E Nelson et al.
Krista N Bohlen et al.
This study evaluated the timing, use, and clinical outcomes of the GeneFolio® Pharmacogenomic Panel in a healthcare setting with patients managed by primary care providers or by psychiatrists. Participants were randomized to receive a phar...
Randomized Controlled Trial
The pharmacogenomics journal. 2023 Jan;23(1):21-27. DOI:10.1038/s41397-022-00292-6 2023
Meta-analysis of pharmacogenetic clinical decision support systems for the treatment of major depressive disorder [0.03%]
meta分析支持重大抑郁症治疗的药物基因组临床决策系统
Valentin Skryabin,Ilya Rozochkin,Mikhail Zastrozhin et al.
Valentin Skryabin et al.
The study aimed to conduct a meta-analysis of studies comparing pharmacogenetically guided dosing of antidepressants with empiric standard of care. Publications referring to genotype-guided antidepressant therapy were identified via PubMed,...
Influence of UGT1A1 and SLC22A6 polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults: a NEAT001/ANRS143 sub-study [0.03%]
UGT1A1和SLC22A6多态性对人类免疫缺陷病毒感染成人中拉替拉韦群体药代动力学和药效学的影响：NEAT001/ANRS143亚研究
Rohan Gurjar,Laura Dickinson,Daniel Carr et al.
Rohan Gurjar et al.
Using concentration-time data from the NEAT001/ARNS143 study (single sample at week 4 and 24), we determined raltegravir pharmacokinetic parameters using nonlinear mixed effects modelling (NONMEM v.7.3; 602 samples from 349 patients) and in...
Do genetics contribute to TNF inhibitor response prediction in Psoriatic Arthritis? [0.03%]
遗传学在预测银屑病关节炎肿瘤坏死因子抑制剂反应中的作用？
Philippa D K Curry,Andrew P Morris,Anne Barton et al.
Philippa D K Curry et al.
Psoriatic arthritis (PsA) is a heterogeneous chronic musculoskeletal disease, affecting up to 30% of people with psoriasis. Research into PsA pathogenesis has led to the development of targeted therapies, including Tumor Necrosis Factor inh...
Protein network and pathway analysis in a pharmacogenetic study of cyclosporine treatment response in Greek patients with psoriasis [0.03%]
希腊银屑病患者环孢素治疗反应的药物基因组学研究中的蛋白质相互作用网络和通路分析
Charalabos Antonatos,Aikaterini Patsatsi,Efterpi Zafiriou et al.
Charalabos Antonatos et al.
Although cyclosporine comprises a well-established systemic therapy for psoriasis, patients show important heterogeneity in their treatment response. The aim of our study was the pharmacogenetic analysis of 200 Greek patients with psoriasis...
Publisher Correction: Cyrius: accurate CYP2D6 genotyping using whole-genome sequencing data [0.03%]
出版更正：Cyrius：使用全基因组测序数据进行准确的CYP2D6基因分型
Xiao Chen,Fei Shen,Nina Gonzaludo et al.
Xiao Chen et al.
Published Erratum
The pharmacogenomics journal. 2022 Dec;22(5-6):308. DOI:10.1038/s41397-022-00287-3 2022
Drug genetic associations with COVID-19 manifestations: a data mining and network biology approach [0.03%]
基于数据挖掘和网络生物学的药物遗传关联及COVID-19表现形式关系研究
Theodosia Charitou,Panagiota I Kontou,Ioannis A Tamposis et al.
Theodosia Charitou et al.
Available drugs have been used as an urgent attempt through clinical trials to minimize severe cases of hospitalizations with Coronavirus disease (COVID-19), however, there are limited data on common pharmacogenomics affecting concomitant m...
The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data [0.03%]
主要药物代谢细胞色素P450基因的遗传谱系-对大规模人群测序数据的最新分析
Yitian Zhou,Volker M Lauschke
Yitian Zhou
Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and dosing. We previously reported the distribution of the most r...
Development of an extensive workflow for comprehensive clinical pharmacogenomic profiling: lessons from a pilot study on 100 whole exome sequencing data [0.03%]
针对100例外显予测序数据进行临床药物基因分型综合分析的广泛工作流程的研发：来自试点研究的启示
Alireza Tafazoli,Maaike van der Lee,Jesse J Swen et al.
Alireza Tafazoli et al.
This pilot study is aimed at implementing an approach for comprehensive clinical pharmacogenomics (PGx) profiling. Fifty patients with cardiovascular diseases and 50 healthy individuals underwent whole-exome sequencing. Data on 1800 PGx gen...