DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship? [0.03%]
DNA聚合酶γ变异体与儿童急性淋巴细胞白血病维持治疗中的肝毒性之间是否存在因果关系？
Tekla Harju,Anri Hurme-Niiranen,Maria Suo-Palosaari et al.
Tekla Harju et al.
Hepatotoxicity is a frequent complication during maintenance therapy of acute lymphoblastic leukemia (ALL) with 6-mercaptopurine and methotrexate. Elevated levels of methylated 6-mercaptopurine metabolites (MeMP) are associated with hepatot...
Polygenic risk scores analyses of psychiatric and metabolic traits with antipsychotic-induced weight gain in schizophrenia: an exploratory study [0.03%]
精神疾病和代谢特征多基因风险评分与抗精神病药物引起的体重增加的关系：一项探索性研究
Kazunari Yoshida,Victoria S Marshe,Samar S M Elsheikh et al.
Kazunari Yoshida et al.
Given the polygenic nature of antipsychotic-induced weight gain (AIWG), we investigated whether polygenic risk scores (PRS) for various psychiatric and metabolic traits were associated with AIWG. We included individuals with schizophrenia (...
One year of experience with combined pharmacokinetic/pharmacogenetic monitoring of anti-TNF alpha agents: a retrospective study [0.03%]
抗TNF-α药物联合药代动力学/药代遗传学监测的回顾性研究经验一年总结
Stefania Cheli,Diego Savino,Annalisa De Silvestri et al.
Stefania Cheli et al.
Anti-tumor necrosis factor alpha (anti-TNFα) inhibitors are used extensively for the management of moderate to severe inflammatory bowel disease (IBD) in both adult and pediatric patients. Unfortunately, not all patients show an optimal re...
Non-steroidal anti-inflammatory drug target gene associations with major depressive disorders: a Mendelian randomisation study integrating GWAS, eQTL and mQTL Data [0.03%]
整合GWAS、eQTL和mQTL数据的孟德尔随机化研究：非甾体抗炎药靶基因与重大抑郁症的关系
Qian He,Kevin Chun Hei Wu,Adam N Bennett et al.
Qian He et al.
Previous observational studies reported associations between non-steroidal anti-inflammatory drugs (NSAIDs) and major depressive disorder (MDD), however, these associations are often inconsistent and underlying biological mechanisms are sti...
The expression level of Neuronal Calcium Sensor 1 can predict the prognosis of cytogenetically normal AML [0.03%]
神经钙调素1表达量可以作为染色体核型正常急性髓系白血病患者预后的预测标志物
Weilong Zhang,Jing Wang,Wei Li et al.
Weilong Zhang et al.
Acute myeloid leukemia (AML) is malignant clonal expansion of myeloid blasts with high heterogeneity and numerous molecular biomarkers have been found to judge the prognosis in some specific classifications of AML. Furthermore, as for patie...
Targeted next-generation sequencing of genes involved in Warfarin Pharmacodynamics and pharmacokinetics pathways using the Saudi Warfarin Pharmacogenetic study (SWAP) [0.03%]
利用沙特华法林药物基因组学研究（SWAP）对华法林药动学和药效学相关基因进行目标下一代测序
Maha Al Ammari,Bader Almuzzaini,Khalid Al Sulaiman et al.
Maha Al Ammari et al.
Background: Warfarin is an oral anticoagulant commonly used for treatment and prophylaxis against thromboembolic events. Warfarins's narrow therapeutic index window is one of the main challenges in clinical practice; thus...
Sequencing of genes of drug response in tumor DNA and implications for precision medicine in cancer patients [0.03%]
肿瘤DNA中药物反应基因的测序及其对癌症患者精准医学的影响
Nancy Gillis,Amy S Etheridge,Sushant A Patil et al.
Nancy Gillis et al.
Tumor DNA sequencing is becoming standard-of-care for patient treatment decisions. We evaluated genotype concordance between tumor DNA and genomic DNA from blood and catalogued functional effects of somatic mutations in 21 drug response gen...
Investigating genetic variants for treatment response to selective serotonin reuptake inhibitors in syndromal factors and side effects among patients with depression in Taiwanese Han population [0.03%]
探究台湾汉族抑郁症患者中影响选择性五羟色胺再摄取抑制剂疗效，综合征因素及副作用的遗传变异位点
Shiau-Shian Huang,Yi-Ting Chen,Mei-Hsin Su et al.
Shiau-Shian Huang et al.
Major depressive disorder (MDD) is associated with high heterogeneity in clinical presentation. In addition, response to treatment with selective serotonin reuptake inhibitors (SSRIs) varies considerably among patients. Therefore, identifyi...
Bioinformatics driven discovery of small molecule compounds that modulate the FOXM1 and PPARA pathway activities in breast cancer [0.03%]
基于生物信息学发现可调节乳腺癌中FOXM1和PPARA通路活性的小分子化合物
Shujun Huang,Pingzhao Hu,Ted M Lakowski
Shujun Huang
Our previous studies demonstrated that the FOXM1 pathway is upregulated and the PPARA pathway downregulated in breast cancer (BC), and especially in the triple negative breast cancer (TNBC) subtype. Targeting the two pathways may offer pote...
The organoid as reliable cancer modeling in personalized medicine, does applicable in precision medicine of head and neck squamous cell carcinoma? [0.03%]
类器官作为个性化医学中可靠的癌症模型，在头颈部鳞状细胞癌的精准医疗中是否适用？
Alieh Farshbaf,Malihe Lotfi,Reza Zare et al.
Alieh Farshbaf et al.
Head and neck squamous cell carcinomas (HNSCCs) are introduced as the sixth most common cancer in the world. Detection of predictive biomarkers improve early diagnosis and prognosis. Recent cancer researches provide a new avenue for organoi...