Deciphering fibroblast-induced drug resistance in non-small cell lung carcinoma through patient-derived organoids in agarose microwells [0.03%]
通过agarose微井中的患者衍生类器官破译成纤维细胞诱导的非小细胞肺癌药物抗性
Qiyue Luan,Ines Pulido,Angelique Isagirre et al.
Qiyue Luan et al.
Patient-derived organoids (PDOs) serve as invaluable 3D tumor models, retaining the histological complexity and genetic heterogeneity found in primary tumors. However, the limitation of small sample volumes and the lack of tailored platform...
Confining calcium oxalate crystal growth in a carbonated apatite-coated microfluidic channel to better understand the role of Randall's plaque in kidney stone formation [0.03%]
在碳酸钙磷灰石涂层微流控通道中限制草酸钙晶体的生长以更好地理解兰德尔斑块在肾结石形成中的作用
Samantha Bourg,Karol Rakotozandriny,Ivan T Lucas et al.
Samantha Bourg et al.
Effective prevention of recurrent kidney stone disease requires the understanding of the mechanisms of its formation. Numerous in vivo observations have demonstrated that a large number of pathological calcium oxalate kidney stones develop ...
Dynamic behavior of floating magnetic liquid marbles under steady and pulse-width-modulated magnetic fields [0.03%]
稳恒磁场和脉宽调制磁场下磁液滴的动态行为研究
Hossein Dayyani,Alireza Mohseni,Mohamad Ali Bijarchi
Hossein Dayyani
Liquid marbles show promising potential for digital microfluidic devices due to their lower friction with the platform surface than non-covered droplets. In this study, the manipulation of a biocompatible magnetic liquid marble with a magne...
Multifunctional cardiac microphysiological system based on transparent ITO electrodes for simultaneous optical measurement and electrical signal monitoring [0.03%]
基于透明的ITO电极的心脏微生理系统的多性能功能以实现同时光学测定和电气信号监测
Zhangjie Li,Kai Niu,Chenyang Zhou et al.
Zhangjie Li et al.
Drug-induced cardiotoxicity is a significant contributor to drug recalls, primarily attributed to limitations in existing drug screening platforms. Traditional heart-on-a-chip platforms often employ metallic electrodes to record cardiomyocy...
Zhaoxian Chen,Wei Wang,Hao Tian et al.
Zhaoxian Chen et al.
For the past few years, sweat analysis for health monitoring has attracted increasing attention benefiting from wearable technology. In related research, the sensitive detection of uric acid (UA) in sweat with complex composition based on s...
A microfluidic chip for sustained oxygen gradient formation in the intestine ex vivo [0.03%]
用于肠外持续氧浓度梯度形成的微流控芯片
Lauren M Delong,Colby E Witt,Madison Pennell et al.
Lauren M Delong et al.
The oxygen gradient across the intestine influences intestinal physiology and the microbial environment of the microbiome. The microbiome releases metabolites that communicate with enterochromaffin cells, neuronal cells, and resident immune...
A miniprotein receptor electrochemical biosensor chip based on quantum dots [0.03%]
基于量子点的迷你蛋白受体电化学生物传感器芯片
Yunong Zhao,Juan Han,Jing Huang et al.
Yunong Zhao et al.
Recently protein binders have emerged as a promising substitute for antibodies due to their high specificity and low cost. Herein, we demonstrate an electrochemical biosensor chip through the electronic labelling strategy using lead sulfide...
Test strip coupled Cas12a-assisted signal amplification strategy for sensitive detection of uracil-DNA glycosylase [0.03%]
用于检测尿嘧啶-DNA糖基化酶的测试条耦合Cas12a辅助信号放大策略
Bin Guo,Chong Hu,Zeping Yang et al.
Bin Guo et al.
Uracil-DNA glycosylase (UDG) is a base excision repair (BER) enzyme, which catalyzes the hydrolysis of uracil bases in DNA chains that contain uracil and N-glycosidic bonds of the sugar phosphate backbone. The expression of UDG enzyme is as...
Liyu Dai,Xiaomin Wu,Huimin Hou et al.
Liyu Dai et al.
The transportation and control of microfluidics have an important influence on the fields of biology, chemistry, and medicine. Pump systems based on the electrocapillary effect and room-temperature liquid metal droplets have attracted exten...
Thomas Lehnert,Martin A M Gijs
Thomas Lehnert
Microorganisms, encompassing both uni- and multicellular entities, exhibit remarkable diversity as omnipresent life forms in nature. They play a pivotal role by supplying essential components for sustaining biological processes across diver...