Associating the morphology of helper T cells with cytokine activity through imaging flow cytometry and deep learning [0.03%]
通过影像流式细胞仪和深度学习关联辅助T细胞形态与细胞因子活性
Natsumi Tiffany Ishii,Ikuo Hieda,Yaqi Zhao et al.
Natsumi Tiffany Ishii et al.
The immune system protects the body from foreign substances, such as viruses and bacteria. Among its key orchestrators are helper T cells, which coordinate immune responses by activating other immune cells to eliminate these threats. Helper...
A biomimetic microphysiological system predicts the impact of sepsis therapeutics on neutrophil-endothelial dynamics [0.03%]
一种类器官系统预测脓毒症治疗对中性粒细胞-内皮细胞动态的影响
Dan Liu,Nazgol Esmalian Afyouni,Qingliang Yang et al.
Dan Liu et al.
Current preclinical models fail to capture human neutrophil-endothelial interactions central to sepsis, contributing to repeated failure of candidate therapeutics in clinical trials. Here, we present a biomimetic microphysiological system (...
On-demand microfluidic encapsulation of Caenorhabditis elegans in hydrogel for long-term observation via AI detection [0.03%]
基于AI检测的秀丽隐杆线虫在水凝胶中的按需微流控封装及长期观察研究
Sinthuran Jegatheeswaran,Teo Mesrkhani,Wei Liu et al.
Sinthuran Jegatheeswaran et al.
Biocompatible hydrogel encapsulation of model organisms, such as Caenorhabditis elegans, is highly desirable over chemical or mechanical immobilization methods that can harm health and hinder long term imaging studies. This study introduces...
Luke A Beardslee,E Kendall Williams,Durga Gajula et al.
Luke A Beardslee et al.
Thrombocytopenia is a major issue in pediatric patients undergoing therapy for hematological malignancies. A point-of-care test to measure platelet count will help alleviate the burden for these patients and their families by allowing them ...
EPGD co-delivery of doxorubicin and gemcitabine enhances activity in EpCAM-high tumour models with lower renal injury-associated readouts in a microfluidic co-culture platform [0.03%]
一种微流控共培养平台通过EPGD共输送多西他赛和吉西他滨增强EpCAM高表达肿瘤模型的活性并降低与肾损伤相关的读数
Qinrui Lu,Guohua Wu,Mengjiao Xia et al.
Qinrui Lu et al.
Cytotoxic chemotherapy remains indispensable for many epithelial malignancies, yet gemcitabine (GEM) and doxorubicin (DOX) are constrained by a narrow therapeutic index and clinically significant toxicity. Here, we developed an epithelial c...
Reversible static-site PCR via dual-phase confinement in digital microfluidics [0.03%]
数字微流体中通过双相限制实现静态站点PCR的可逆性
Eduardo Cervantes,Rohit Lal,Hyunju Leycam et al.
Eduardo Cervantes et al.
Digital microfluidics (DMF) enables programmable manipulation of discrete droplets for multi-step biochemical workflows; however, integrating polymerase chain reaction (PCR) into reconfigurable DMF systems remains challenging due to evapora...
A versatile microfluidic electrochemical platform for diffusion-controlled, quasi-one-dimensional interfacial studies [0.03%]
一种用于扩散控制、准一维界面研究的微流体电化学平台
Shreyanshu Agrawal,Alexander Saperstein,Farzam Zoueshtiagh et al.
Shreyanshu Agrawal et al.
We present a quasi-one-dimensional microfluidic electrochemical platform that suppresses convection through microscale confinement and eliminates electric field singularities by combining thin film electrodes with a dielectric overhang that...
Development of dual-function optical microneedle lens array for skin cancer treatment by photodynamic therapy [0.03%]
用于光动力治疗皮肤癌的双功能光学微针透镜阵列的研发
Anthony Lefebvre,Wataru Hanamoto,Jongho Park et al.
Anthony Lefebvre et al.
Skin cancer is among the most prevalent cancers worldwide, with melanoma accounting for most skin cancer-related deaths owing to its aggressiveness and metastatic potential. Although treatments including surgery, radiotherapy, immunotherapy...
Bram Servais,David R Nisbet,David J Collins
Bram Servais
Microfluidic devices remain difficult to translate into commercial products, particularly for three-dimensional (3D) applications. While soft lithography offers high-resolution features and biocompatibility, its workflows and planar geometr...
Artificial intelligence-augmented organ- and organoid-on-a-chip for drug screening [0.03%]
基于人工智能的器官芯片与类器官芯片在药物筛选中的应用
Chenxi Song,Tengyun Li,Hang Guan et al.
Chenxi Song et al.
Organ- and organoid-on-a-chip technologies provide critical human-relevant models for drug screening. Despite their promise, translating their complex biological outputs into reproducible, quantifiable, and pharmacologically interpretable r...