Engineering spatially defined extracellular matrix gradients to govern self-organized multicellular aggregates in a glioblastoma-on-a-chip [0.03%]
Jianing Li,Xinghua Gao,Xiaoling Yang et al.
Jianing Li et al.
The spatial heterogeneity of biochemical cues within the tumor microenvironment (TME) critically influences cancer progression and therapeutic resistance. However, existing models often lack the capacity to generate stable, quantitative con...
Electroporation of spheroids using an electric field gradient: a tool to study intensity-dependent permeabilization [0.03%]
采用电场梯度穿刺球体的研究强度依赖性渗透性的一种工具
Théo Le Berre,Julien Marchalot,Guilhem Rival et al.
Théo Le Berre et al.
Electroporation (EPN) is the process by which cell membranes become transiently or permanently permeable upon exposure to pulsed electric fields of suitable intensity and duration. Depending on the pulse parameters, permeabilization can be ...
A physicochemically compatible ferrofluid droplet robotic system for automated bioanalytical assays [0.03%]
一种用于自动化生物分析的物理和化学兼容的铁流体液滴机器人系统
Christina C K Au Yeung,Ruotong Zhang,Chengzhi Zhang et al.
Christina C K Au Yeung et al.
Droplet robotics is an emerging area of research focused on harnessing externally programmable physical fields to drive liquid droplet motion and automate complex fluidic operations. One approach for driving droplet robotic systems utilizes...
Three-dimensional intestinal tube with a crypt-like uneven inner wall fabricated using electrolysis-generated microbubbles [0.03%]
使用电解生成的微气泡制造类似肠隐窝凹凸不平内壁的三维肠道管模型
Shota Uramoto,Shuma Tanaka,Shun Itai et al.
Shota Uramoto et al.
We present a three-dimensional intestinal hydrogel tube with a crypt-like uneven inner wall fabricated using electrolysis-generated microbubbles. The uneven structure observed in crypt and villus intestinal epithelial tissue in vivo serves ...
An integrated microfluidic system with shear force control for an automatically modified mRNA display technique for screening high-specificity peptide probes [0.03%]
一种集成了剪切力控制的微流体系统，用于自动改进的mRNA展示技术筛选高特异性肽探针
Hao-Yen Wang,Shih-Yu Shen,Lily Hui-Ching Wang et al.
Hao-Yen Wang et al.
We developed a low-cost, integrated microfluidic system (IMS) featuring micropumps, microvalves, micromixers, and thermoelectric modules that fully automated a modified-mRNA display technique for the screening of high-specificity peptide pr...
Mechanobiological regulation of T cells via transient viscoelastic microfluidic confinement [0.03%]
基于短暂黏弹微流控限制的T细胞机械生物学调节机制研究
Mohammad Asghari,Morteza Aramesh,Prerit Mathur et al.
Mohammad Asghari et al.
T cell migration through confined spaces, such as venular blood vessel walls or tumor tissues, is crucial for delivering immune effectors to sites of infection or disease. While mechanical confinement has been shown to trigger signaling pat...
Repeated exposure of anticancer agents to tumorspheres in open-surface microwell arrays for modeling chemotherapy-induced dormancy in colorectal cancer [0.03%]
采用开放式微阵列多次暴露抗癌药物以模拟结直肠癌化疗诱导的休眠肿瘤球体模型
Hui Kang,Xiaogang Wang,Weijie Ye et al.
Hui Kang et al.
Dormant cancer cells (DCCs) serve as crucial contributors to tumor drug resistance and recurrence; however, the mechanisms underlying their formation and biological characteristics remain inadequately understood. The establishment of reliab...
Carbonate reservoir surface-mimicking platform for CO2-seawater-concrete flooding [0.03%]
仿碳酸盐岩地层采油的二氧化碳-海水-混凝土驱油体系及驱油机理研究
Abhishek Ratanpara,Daniel Guerrero,Diana Cho et al.
Abhishek Ratanpara et al.
Microfluidic platforms are increasingly used in enhanced oil recovery (EOR) studies due to their ability to visualize and control fluid displacement at the pore scale. While many designs successfully replicate reservoir geometries, mimickin...
Use of poly(glycerol sebacate) as an alternative to poly(dimethylsiloxane) as a platform for making micro-fluidic channels [0.03%]
聚甘油癸二酸酯作为制备微流体通道的材料替代聚二甲基硅氧烷的应用研究
Yasmeena Ashraf,Animangsu Ghatak
Yasmeena Ashraf
Poly(dimethylsiloxane) (PDMS) has been used extensively for making microfluidic devices because of several favorable features: optical transparency, bio-compatibility, easy moldability and its inertness towards most materials. However, PDMS...
Oxygen-free discontinuous dewetting in a degassed mold for anisotropic colloidal hydrogel microparticle synthesis [0.03%]
无氧模具中退火胶体微粒子的合成过程中的不连续脱粘现象研究
Jiwoo Kim,Jun Hee Choi,Jeongmin Kim et al.
Jiwoo Kim et al.
Anisotropic colloidal hydrogel microparticles offer unique advantages owing to their shape-dependent interactions, and enhanced diffusion and reaction kinetics, which is favorable in solution-based processes. However, their fabrication rema...