Human hair regeneration using organoids and hair-on-chip technologies [0.03%]
使用类器官和毛囊芯片技术进行体外人类头发再生
Imaan A Ahmed,Abbas Shafiee
Imaan A Ahmed
The hair follicle is a complex, dynamic mini organ that plays various important roles in facilitating the function of human skin. As human hair follicles do not naturally form after birth, there is a demand for methods to restore hair folli...
Centrifuge-free separation of plasma from milliliters of whole blood for point-of-care diagnostics [0.03%]
用于即时检测的离心机免分血浆法
Christia M Victoriano,Bianca Arraiza Carlo,Abigail G Ayers et al.
Christia M Victoriano et al.
Performing efficient plasma separation from whole blood, a vital sample matrix for diagnostics, in point-of-care settings remains challenging, particularly for sensitive assays that require larger volumes than can be obtained from a finger ...
A compact low-power valveless piezoelectric micropump with a nested rectification structure [0.03%]
一种新型嵌套整流结构的无阀压电微型泵
Jie Shan,Aoyu Ma,Cuixue Ren et al.
Jie Shan et al.
The field of implantable medical devices imposes stringent requirements on piezoelectric micropumps, particularly in terms of low-power operation, miniaturization, and backflow suppression. This study proposes a novel valveless piezoelectri...
High-throughput microfluidic platform for modelling inflammatory responses of human articular chondrocytes under variable fluid shear stress [0.03%]
一种用于模拟人类关节软骨细胞在不同流体剪切应力下炎症反应的高通量微流控平台
Aldeliane M da Silva,Priscila Campioni Rodrigues,Meriem Lamghari et al.
Aldeliane M da Silva et al.
Inflammation plays a critical role in osteoarthritis (OA), a debilitating joint disease characterized by cartilage degradation, chronic pain, and disability. The absence of approved disease-modifying OA drugs underscores the need for physio...
Gut-liver-on-a-chip enables mechanistic study and risk assessment of drug-induced liver injury and drug-drug interactions [0.03%]
一种芯片上的肠-肝模型用于药物性肝损伤及药物相互作用的机理研究和风险评估
Yue Yu,Tian Lin,Xiao Ye et al.
Yue Yu et al.
Current preclinical models face challenges in recapitulating organ-level interactions affecting drug safety, and there has been little investigation into drug toxicity and related DILI. We present a pump-less gut-liver-on-chip, enabling int...
A compact superlattice as a label-free surface-enhanced Raman scattering substrate for noninvasive urine testing for the diagnosis of lung cancer [0.03%]
一种用于非侵入性尿液检测肺癌的表面增强拉曼散射基底的紧致超晶格（无标签）
Kaili Zhang,Yuancai Ge,Yi Xu et al.
Kaili Zhang et al.
The development of noninvasive cancer diagnosis approaches may provide convenient, remote, painless diagnosis, instant healthcare, and postoperative follow-up. Label-free surface-enhanced Raman spectroscopy (SERS) is becoming a powerful app...
Microfluidic well plates integrated with passive nematode culture chambers for multiplexed chemical toxicity assays in C. elegans [0.03%]
一种用于秀丽隐杆线虫多路化学毒性检测的微流体井板集成被动培养腔室
Bushra Rahman,Purushottam Soni,Atiyya P Saroyia et al.
Bushra Rahman et al.
Whole-organism toxicity assays are essential for evaluating the safety of chemicals, but mammalian models remain costly and low throughput, contributing to a global backlog of untested chemicals. The micro-organism C. elegans has emerged as...
An automated modular microfluidic platform for end-to-end mRNA synthesis and purification [0.03%]
一种用于从头到尾的mRNA合成和纯化的自动化模块化微流体平台
Vikas Sharma,Amirreza Mottafegh,Jeong-Un Joo et al.
Vikas Sharma et al.
Manual, batchwise downstream operations remain a major bottleneck in translating microfluidic mRNA synthesis into practical production workflows. Building on an oscillatory microfluidic IVT module (Os(IVT)) previously established for intens...
Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells [0.03%]
细菌外泌体通过促炎刺激免疫细胞间接破坏人体干细胞衍生的血脑屏障芯片稳定性
Louis P Widom,Panteha Torabian,Michelle A Trempel et al.
Louis P Widom et al.
Pathogenic bacterial extracellular vesicles (BEVs) can disrupt the blood-brain barrier (BBB), leading to neuroinflammation. Prior in vitro studies of this process were performed in simple models that may have lacked important physiological ...
Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery [0.03%]
基于CAF驱动的药物输送障碍解码的肿瘤芯片运输表型平台
Doriane Le Manach,Vincent Senez,Matthias Nees
Doriane Le Manach
Physical barriers within solid tumors constitute a fundamental but often overlooked mechanism of therapeutic resistance, contributing to the poor success rate of cancer drug translation. Therapeutic molecules often fail to reach their inten...