Microfluidic compartmentalization reveals that ferrostatin-1 restores directional mitochondrial transport in Aβ-challenged neurons [0.03%]
微流控隔室化揭示了铁洛统计1号可以恢复Aβ损伤神经元中的线粒体定向运输
Nad&#x;a Majerníková,Beatrice Corci,Yuequ Zhang et al.
Nad&#x;a Majerníková et al.
Mitochondrial dysfunction is a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD). While ferroptosis has been implicated in AD through iron accumulation and amyloid β (Aβ)-mediated toxicity, its role in mitochondri...
On cloud microfluidic experiment platform powered by in situ maskless lithography [0.03%]
基于原位无掩模光刻的云端微流控实验平台
Ratul Paul,Declan Coster,Yuwen Zhao et al.
Ratul Paul et al.
Microfluidics has seen rapid growth across research and development, offering significant potential for scientific, engineering, and commercial applications. Yet, current teaching methodologies often lack a hands-on, problem-based learning ...
Stretchable mesoporous electrodes as a versatile platform for minimally invasive surgical devices [0.03%]
可拉伸介孔电极在微创外科设备中的广泛应用研究
Michael Abraham Listyawan,Chi Cong Nguyen,Tran Bach Dang et al.
Michael Abraham Listyawan et al.
Minimally invasive surgery (MIS) is a vital procedure for the treatment of several cardiac and neural diseases, such as clearing clogged arteries, pacing irregular heartbeats, monitoring intracranial pressure, and draining excess cerebrospi...
Porous microneedle-based electrochemical aptamer biosensor for the collection and quantitative analysis of dry eye disease biomarkers [0.03%]
用于干燥性眼病生物标志物采集和定量分析的基于微针的电化学生物传感器
Eira Beryle Ko,Tianli Hu,Ya Zhang et al.
Eira Beryle Ko et al.
Dry eye disease (DED) is a prevalent ocular disorder driven by tear film instability and inflammation. The quantitative measurement of molecular biomarkers in tears can provide reliable and accurate diagnosis and management of DED. This art...
Predicting human pharmacokinetic parameters of drugs using a multi-tissue chip platform integrating liver, kidney, and skeletal muscle microphysiological systems [0.03%]
基于集成了肝、肾和骨骼肌微生理系统的多组织芯片平台预测药物的人体药动学参数
Jason Sherfey,Shiny Amala Priya Rajan,Lauren M Nichols et al.
Jason Sherfey et al.
Accurate prediction of human pharmacokinetic (PK) parameters is a critical step in drug development. While simple in vitro assays provide insight into discrete metabolic processes, they cannot recapitulate the complex multi-organ interactio...
Ultra-high throughput droplet microfluidics for cultivation and functional screening of environmental microbial strains and consortia [0.03%]
一种用于环境微生物菌株和群落培养及功能筛选的超高通量微流体液滴技术
Luca Potenza,Jozef Krzak,Maciej S Andrzejewski et al.
Luca Potenza et al.
Screening of microbial diversity is critical for discovering novel strains with enhanced biocatalytic capabilities. Traditional cultivation techniques often miss rare or slow-growing microorganisms, limiting our understanding of environment...
A combinatorial screening platform for in situ gene delivery to adherent cells via digital microfluidics and flexible electrodes [0.03%]
基于数字微流控和柔性电极的贴壁细胞原位基因递送组合筛选平台
Yi Weng,Xiangyu Ren,Fuqiang Guo et al.
Yi Weng et al.
Conventional electroporation techniques are often limited by low throughput, high reagent consumption, and, critically, the requirement for cell suspension. The latter necessitates enzymatic detachment, subjecting cells to significant physi...
Rapid fabrication of solvent-compatible NOA 81 microfluidic devices for double-emulsion microfluidics [0.03%]
一种快速制备适用于溶剂的NOA81微流控芯片的新方法及其在双重乳液微流控装置中的应用研究
Ryan Garry,Vladimir Sincari,Wentao Xu et al.
Ryan Garry et al.
While PDMS-based microfluidic devices set the rapid prototyping standard, their application is limited by incompatibility with many non-polar solvents. This inability to tolerate organic solvents significantly restricts the types of materia...
Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles [0.03%]
用于制造巨单层囊泡的双乳状液脱湿动力学的系统调查
Wenyang Jing,Heewon Noh,Timothy J C Tan et al.
Wenyang Jing et al.
Giant unilamellar vesicles (GUVs) embody biomimetic membranes with compartmentalization and serve as simplified models to better understand complex biochemical and biophysical processes. Recently, double emulsion droplet microfluidics has p...
A rapid in situ synthesis of bioinspired nanoflowers on a microfluidic dipstick for point-of-care diagnosis of normoglycemic glycosuria [0.03%]
一种在微流控试纸上的生物启发型纳米花的快速原位合成技术用于生化指标正常血糖尿糖的即时诊断检测
Saminu Abdullahi,Mohamed Ishag Hassan Gama,Mubashir Ali et al.
Saminu Abdullahi et al.
Reliable detection of urinary glucose is crucial for the early diagnosis of renal tubular dysfunctions, including normoglycemic glycosuria (NG), a condition characterized by glucose excretion despite normal blood glucose levels. Conventiona...