Flow-programmable and reversible surface-induced LLPS in nanofluidic channels [0.03%]
纳米流体通道中可流动编程和可逆的表面诱导液-液相分离现象
Ryoichi Ohta,Zhixin Zhao,Xuan Yan et al.
Ryoichi Ohta et al.
Liquid-liquid phase separation (LLPS) functions as a high-performance reactor strategy in cells, creating dynamic "membrane-less organelles" that selectively concentrate biomolecules. Mimicking this volumetric strategy on a chip offers a ro...
An AI-enabled tool for quantifying overlapping red blood cell sickling dynamics in microfluidic assays [0.03%]
一种人工智能驱动的工具，可在微流体装置中量化重叠红细胞镰变动力学
Nikhil Kadivar,Guansheng Li,Jianlu Zheng et al.
Nikhil Kadivar et al.
Understanding sickle cell dynamics requires accurate identification of morphological transitions under diverse biophysical conditions, particularly in densely packed and overlapping cell populations. In microfluidic sickling assays, simple ...
Jiaxi Peng,Vigneshwar Rajesh,Jiarui Shen et al.
Jiaxi Peng et al.
Wastewater surveillance programs enable large-scale analysis of viral pathogens, uncovering details such as mutation types and quantitative trends in infection prevalence. To enable sensitive and precise analysis of viral variants from wast...
Capillary microsampling enables on-site collection and storage of plant sap [0.03%]
微毛细管取样法可在现场采集和保存植物汁液
Ellinor Hedberg,Jaime Sebastián-Azcona,Federico Ribet et al.
Ellinor Hedberg et al.
Plant sap analysis typically relies on destructive sampling and immediate freezing, limiting field deployment and longitudinal studies. We introduce a minimally invasive microfluidic device that extracts sap from the stem of Solanum lycoper...
Naveen Kumar K R,Saima Hamid,A K Niketa et al.
Naveen Kumar K R et al.
Poly(dimethylsiloxane) (PDMS) is the material of choice for fabricating high-performance microfluidic devices, yet its intrinsic limitations, such as poor surface wettability, chemical instability, and porosity, continue to constrain device...
Size-based sorting of cancer cells reveals functional heterogeneity among subpopulations [0.03%]
基于大小的癌症细胞分选揭示了亚群之间的功能异质性
Esra Yilmaz,Zhimeng Fan,Jason P Beech et al.
Esra Yilmaz et al.
Cancer cells display marked heterogeneity in size and morphology, traits long recognized in pathology as indicators of pleomorphism and poor prognosis. Yet, the functional significance and phenotypic consequences of these morphological vari...
Nanomembrane-based microfluidic platform with embedded electrical pressure transducer for on-chip nanoparticle quantification [0.03%]
基于纳米膜的内置电气压力传感器的微流控平台芯片上纳米颗粒定量分析
Zachary Morris,Juliana Chawich,Owen Perreault et al.
Zachary Morris et al.
Accurate quantification of nanoparticle concentration is important in a host of fields, particularly in nanomedicine, electronics, and catalysis. Microfluidic systems present an opportunity to develop low-cost tests for nanoparticle quantif...
A contractile force measurement system for hiPSC-derived cardiac tissue integrated with an ultrathin, stretchable nanomesh [0.03%]
一种用于测量hiPSC衍生心脏组织集成超薄可拉伸纳米网的收缩力的测量系统
Shogo Iwai,Daisuke Sasaki,Tetsutaro Kikuchi et al.
Shogo Iwai et al.
Mechanical stretch is a vital factor influencing the structural and functional properties of cardiac tissue, including its contractile force. While various platforms using elastic substrates have been developed to measure the contractile fo...
Dynamic gap structure for high-throughput measurement of cellular mechanical properties [0.03%]
用于细胞力学性质高通量测量的动态位移结构
Doudou Ma,Nobutoshi Ota,Masaya Taniguchi et al.
Doudou Ma et al.
Precise quantification of cellular mechanical properties, such as Young's modulus, is essential for understanding cellular physiology, disease progression, and therapeutic responses. In contrast to existing deformability cytometry approache...
Independent parallel production of tunable blood clot analogues in hourglass-profiled circular PDMS fluidic channels [0.03%]
独立平行制备调谐血液凝块模拟物的方法——在圆形PDMS微流控通道中合成(hoursand型几何结构)
Chun-Hsin Hsu,To-Wen Chen,Wei-Jen Soong et al.
Chun-Hsin Hsu et al.
Rapid removal of occluding blood clots, whether by intravenous thrombolysis or endovascular thrombectomy, can be life-saving. Yet recanalization is not always successful, and the determinants remain incompletely understood. Thrombi exhibit ...