A microfluidic approach to evaluating surface protection from nonspecific antibody adsorption [0.03%]
一种微流体方法评估表面抗非特异性抗体吸附性能
Yulia Tobolovskaya,Bexi M Bustillo-Perez,Yingshan Ma et al.
Yulia Tobolovskaya et al.
Nonspecific antibody adsorption to solid surfaces remains a challenge in the development and use of formulations for immunotherapies, as it can compromise antibody structure and therapeutic function. Here, we introduce a photoluminescent ca...
A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates [0.03%]
基于微流控设计的力学穿孔参数研究——通过调节剪切力、压缩力、粘附力和加载速率来调控膜 pores 的形成
Avi Gupta,Jacqueline Van Zyl,Collin Bushey et al.
Avi Gupta et al.
Efficient and reproducible intracellular delivery is critical for manufacturing next generation cell therapies. Mechanoporation employs mechanical forces, including shear loading, adhesion, and compressive strain, to transiently permeabiliz...
Local chemotactic response of Escherichia coli in fluid and near surfaces [0.03%]
液体和近表面环境中大肠杆菌的局部趋化响应
Adam Gargasson,Julien Bouvard,Carine Douarche et al.
Adam Gargasson et al.
Bacteria can adjust their swimming behaviour in response to chemical variations, a phenomenon known as chemotaxis. This process is characterised by a drift velocity that depends non-linearly on the concentration of chemical species and its ...
Experimental diffusiophoresis of porous and non-porous silica particles in dead-end pore microchannel geometry [0.03%]
死端微通道几何结构中多孔和非多孔二氧化硅颗粒的实验扩散光散射现象研究
Mansoureh Rashidi,Matina Nooryani,Giovanniantonio Natale et al.
Mansoureh Rashidi et al.
The movement of colloids in response to a concentration gradient of solutes, known as diffusiophoresis (DP), plays a crucial role in various applications, including separations, sorting and reactant transport. In this study, we experimental...
Microfluidic insights into microbial impacts on hydrogen flow in underground hydrogen storage [0.03%]
微流控解析地下氢储库中微生物对氢气运移的影响
Yuyi Liu,Diansen Yang
Yuyi Liu
Underground hydrogen storage, involving periodic injection and extraction of hydrogen gas, serves as a crucial approach for achieving energy peak shaving and accommodating large-scale renewable energy. However, microorganisms residing under...
3D printing monolithic, multifunctional polymer acoustofluidic devices with tunable mixing and particle focusing [0.03%]
具有可调混合作用和粒子汇聚作用的单片式多功能聚合物声学流体装置的三维打印技术
Roxanne Kate Balanay,Justin W Yip,Justin Do et al.
Roxanne Kate Balanay et al.
Acoustic forces offer a powerful, contact-free modality for manipulating particles and fluids within microfluidic lab-on-a-chip systems. However, realizing the full potential of acoustic manipulation has been constrained by conventional cle...
Exploring paclitaxel-albumin-loaded neutrophil-like cells via microfluidic-based mechanical deformation for enhanced cargo delivery in glioblastoma therapy [0.03%]
基于微流控力学变形的类中性粒细胞递送载紫杉醇白蛋白纳米粒子用于增强胶质母细胞瘤治疗
Daidi Zhou,Xinghua Gao,Zhiyu Mao et al.
Daidi Zhou et al.
This study investigated the rapid drug delivery capabilities of neutrophil-like cells using a microfluidic chip-based mechanical deformation approach, with an emphasis on glioblastoma treatment at the cellular level. We designed a microflui...
High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform [0.03%]
一种用于高回收率AAV纯化的复式螺旋惯性微流控平台
Alexander Bevacqua,Do Hyun Park,Sheryar Khan et al.
Alexander Bevacqua et al.
The clinical adoption of emerging cell and gene therapies relies on the efficient upstream bioprocessing and high-recovery harvesting of viral vectors. AAV purification from cell culture begins with the removal of cells, through a process c...
Creating an improved workflow for paper-based malaria diagnostics by integrating total lysis of whole blood [0.03%]
通过整合全血完全裂解改善基于纸张的疟疾诊断工作流程
J Prat-Trunas,A Code,Y Avalos-Padilla et al.
J Prat-Trunas et al.
Detection of parasite biomarkers is critical for diagnosis and treatment monitoring; however, proper analysis of whole blood samples typically requires red blood cell lysis. While lysis is easily achieved in laboratory environments, there i...
Droplet microfluidic profiling of NK cell cytotoxicity with machine learning-enabled target-cell death analysis [0.03%]
基于机器学习的靶细胞死亡分析的NK细胞毒性微流体滴数字化研究
Rana S Ozcan,Fatemeh Vahedi,Shina Namakian et al.
Rana S Ozcan et al.
Predicting the clinical efficacy of Natural Killer (NK) cell immunotherapies remains challenging due to functional heterogeneity within effector populations and tumor microenvironment (TME)-mediated suppression. Here, we present a droplet m...