Vertical numbering-up microfluidic architecture for scalable and homogeneous lipid nanoparticle production [0.03%]
一种垂直编号的微流体架构用于规模化和均匀地生产脂质纳米颗粒
Zhaoyu Zhang,Jaejeung Kim,Jinwoo Hwang et al.
Zhaoyu Zhang et al.
Lipid nanoparticles (LNPs) are a key platform for nucleic acid delivery, but their industrial-scale production remains a critical bottleneck. While microfluidics ensures high-quality LNP production, conventional single layer strategies suff...
Machine learning-augmented lateral flow assays for point-of-care infectious disease diagnostics [0.03%]
基于机器学习的横向层析试验在医疗点传染病诊断中的应用研究
Cagla Parmaksizoglu,Isil Cakiroglu,Nazente Atceken et al.
Cagla Parmaksizoglu et al.
Lateral flow assays (LFAs) are among the most widely used point-of-care (PoC) diagnostic platforms for infectious diseases due to their rapid operation, low cost, and user-friendly architecture. However, conventional LFAs remain limited by ...
Integrated microfluidic platform for inertial separation and encapsulation of single cells in droplets [0.03%]
一种集成了惯性分离和液滴包裹单细胞技术的微流控平台
Fariba Malekpour Galogahi,Haotian Cha,Sharda Yadav et al.
Fariba Malekpour Galogahi et al.
The ability to sort and separate large cellular subpopulations based on their intrinsic properties underpins a wide range of biological, diagnostic, and therapeutic applications. For many of these applications, preserving cellular homogenei...
Fluid mechanics of thin blood films to detect anemia and sickle cell disease [0.03%]
薄膜流体动力学检测贫血和镰刀型细胞病
Mahrukh A Mir,Mahesh S Tirumkudulu,Bhavesh Raicha
Mahrukh A Mir
Anemia affects nearly two billion people worldwide, especially in low-income countries, while sickle-cell disease (SCD), which is genetically inherited, is prevalent in sub-Saharan Africa and India. These resource-constrained regions requir...
In vitro space of Disse model for exploration of drug induced hepatotoxicity [0.03%]
一种药物致肝毒性的细胞间隙离体模型研究
Ana Mesic,Antonietta Messina,Zoe Tiprez et al.
Ana Mesic et al.
The limited predictive power of animal models remains a major bottleneck in drug development, particularly in assessing drug-induced liver injury (DILI). To address this, we developed a novel in vitro liver-on-a-chip platform focused on mod...
Digitally programmable microfluidic valving for autonomous, high-resolution continuous chromatographic purification [0.03%]
用于自主、高分辨率连续色谱纯化的数字编程微流体阀技术
Yi-Cheng Liao,Chih-Yi Huang,Yu-Chuan Tang et al.
Yi-Cheng Liao et al.
Continuous microscale purification requires analytical methods that provide deterministic fluid handling, precise temporal control, and contamination-free fraction discrimination. Existing microfluidic and benchtop chromatography systems on...
Machine learning-driven single-cell phenotyping in size-controlled microenvironments via parallel deterministic droplet microfluidics [0.03%]
基于平行确定性微流控技术在尺寸可控微环境中通过机器学习进行单细胞表型分析
Sangmin Lee,Steven O&#x;Donnell,Zhangli Peng et al.
Sangmin Lee et al.
Understanding how individual cells respond to distinct physical microenvironments is critical for mechanobiology, cell therapy, and tissue engineering. Current single-cell encapsulation methods are often limited by Poisson loading and fixed...
A customizable, low-cost 3D-printed device for live cell confinement imaging [0.03%]
一种用于活细胞捕获成像的定制化低成本3D打印设备
Hunter Richman,Jin Ou,Manpreet Khera et al.
Hunter Richman et al.
Physical confinement profoundly shapes cell functions from migration to cancer invasiveness. Although multiple in vitro confinement platforms have been designed to replicate physical constraints while enabling simultaneous live-cell imaging...
Tunable squeeze-activated GHz acoustofluidics for stable trapping and separation of sub-100 nm nanoparticles [0.03%]
可调挤压激活GHz声学流体学在稳定捕获和分离亚100nm纳米粒子中的应用
Yiming Liu,Wei Wei,Hang Qi et al.
Yiming Liu et al.
The precise enrichment and size-selective separation of sub-100 nm biological nanoparticles such as exosomes remain challenging due to their small size and heterogeneity. Conventional GHz acoustofluidic systems suffer from unstable acoustic...
A microfluidic method for controlled generation and trapping of membraneless water-in-water droplets [0.03%]
一种用于无膜水包水液滴精准生成和操控的微流控方法研究
Chi Li,Hailin Fu,Kalpit J Bakal et al.
Chi Li et al.
Aqueous two-phase systems (ATPS) provide a versatile platform for controlling microscale aqueous environments. Microfluidic devices are particularly valuable for studying such systems, as they allow precise control of geometry, flow, and co...